Administrative supplement for NIH INCLUDE Molecular Biology T32 Down Syndrome Supplement

NIH 行政补充品包括分子生物学 T32 唐氏综合症补充品

• 批准号: 9932848
• 负责人: Rytis Prekeris
• 金额: $ 11.3万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9932848
• 关键词: Administrative Supplement; Molecular Biology; United States National Institutes of Health

ABSTRACT. The goal of the T32-Funded Molecular Biology (MOLB) Program at the University of Colorado Anschutz Medical Campus is to train outstanding research scientists and academicians who will become future leaders in their chosen fields and disciplines. As part of this this goal, we teamed up with Linda Crnic Institute for Down Syndrome to train new high-quality scientist dedicated in pursuing biomedical research to enhance our understanding about the causes and potential treatments of Down Syndrome. Our training program is flexible and student-oriented to meet individual needs, with a rigorous curriculum and high standards. Ph.D. in Molecular Biology is designed as a 5-6 year program with rigorous and challenging course work and research thesis. To further develop their skills, all trainees supported by INCLUDE Supplement will attend monthly Crnic Supergroup research meetings, will present and discuss results of their own project at one such meeting, and will attend the annual Crnic Symposium. As the result, trainees will be exposed to multi-disciplinary approaches to studying DS which will complement their training by their thesis Mentors. Trainees supported by this supplement will also participate in all the activities that are designed for other MOLB T32 awardees, namely organizing annual MOLB Symposium and Retreat as well as running monthly “Roundtables” discussion forum. Finally, all three trainees supported by this supplement will present their work during MOLB Annual Retreat during special “Down Syndrome” session. Given the depth, quality, and diversity of our student pool and our demonstrated ability to train high quality students, we request 3 students be supported for one year as part of INCLUDE Supplement.

抽象的。科罗拉多大学T32资助的分子生物学（MOLB）计划的目标 Anschutz医疗校园将培训将成为未来的杰出研究科学家和院士 他们选择的领域和学科的领导者。作为此目标的一部分，我们与琳达·克里奇学院（Linda Crnic Institute）合作 让唐氏综合症培训新的高质量科学家致力于追求生物医学研究以增强 我们对唐氏综合症的原因和潜在治疗的理解。我们的培训计划是 具有严格的课程和高标准的灵活性和以学生为导向，以满足个人需求。博士在 分子生物学设计为5 - 6年的计划，具有严格而挑战课程的工作和研究 论文。为了进一步发展自己的技能，所有受补充剂支持的学员将参加每月CRNIC 超组研究会议，将在一次这样的会议上介绍和讨论自己项目的结果，以及 将参加年度CRNIC研讨会。结果，学员将暴露于多学科 研究DS的方法将完成论文导师的培训。学员支持 该补充剂还将参与为其他Molb T32获奖者设计的所有活动， 即组织年度MOLB研讨会和务虚会以及每月进行每月“圆桌会议”讨论 论坛。最后，这项补充支持的所有三名学员将在Molb年度介绍他们的工作 在特殊“唐氏综合症”会议期间进行撤退。鉴于我们学生池的深度，质量和多样性 我们证明的培训高质量学生的能力，我们要求3名学生获得一年的支持 包括补充剂的一部分。

项目成果

HIFs enhance the transcriptional activation and splicing of adrenomedullin.

• DOI: 10.1158/1541-7786.mcr-13-0607
• 发表时间: 2014-05
• 期刊: Molecular cancer research : MCR
• 作者: Sena JA;Wang L;Pawlus MR;Hu CJ
• 通讯作者: Hu CJ

Gammaherpesvirus 68 infection of endothelial cells requires both host autophagy genes and viral oncogenes for optimal survival and persistence.

内皮细胞的 Gammaherpesvirus 68 感染需要宿主自噬基因和病毒癌基因才能实现最佳存活和持久性。

• DOI: 10.1128/jvi.00001-11
• 发表时间: 2011
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: Suárez,AndreaLuísa;Kong,Raymond;George,Tad;He,Liqiang;Yue,Zhenyu;vanDyk,LindaFaye
• 通讯作者: vanDyk,LindaFaye

Kinetic partitioning during de novo septin filament assembly creates a critical G1 "window of opportunity" for mutant septin function.

在 de novo septin 丝组装过程中的动力学分配为突变 septin 功能创造了一个关键的 G1“机会之窗”。

• DOI: 10.1080/15384101.2016.1196304
• 发表时间: 2016
• 期刊: Cell cycle (Georgetown, Tex.)
• 作者: Schaefer,RachelM;Heasley,LydiaR;Odde,DavidJ;McMurray,MichaelA
• 通讯作者: McMurray,MichaelA

Recruitment and allosteric stimulation of a histone-deubiquitinating enzyme during heterochromatin assembly.

异染色质组装过程中组蛋白去泛素化酶的募集和变构刺激。

• DOI: 10.1074/jbc.ra117.000498
• 发表时间: 2018
• 期刊: The Journal of biological chemistry
• 作者: Zukowski,Alexis;Al-Afaleq,NoufOmar;Duncan,EmilyD;Yao,Tingting;Johnson,AaronM
• 通讯作者: Johnson,AaronM

ADAR Mediated RNA Editing Modulates MicroRNA Targeting in Human Breast Cancer.

ADAR 介导的 RNA 编辑调节人类乳腺癌中的 MicroRNA 靶向。

• DOI: 10.3390/pr6050042
• 发表时间: 2018
• 期刊: Processes (Basel, Switzerland)
• 作者: Roberts,JustinT;Patterson,DillonG;King,ValeriaM;Amin,ShivamV;Polska,CarolineJ;Houserova,Dominika;Crucello,Aline;Barnhill,EmmalineC;Miller,MollyM;Sherman,TimothyD;Borchert,GlenM
• 通讯作者: Borchert,GlenM