Effects of perfluorobutane sulfonate (PFBS) exposure on adverse pregnancy outcomes and fetal development

全氟丁磺酸 (PFBS) 暴露对不良妊娠结局和胎儿发育的影响

• 批准号: 9925851
• 负责人: Liping Feng
• 金额: $ 10.61万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-25 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9925851
• 关键词: Address; Affect; Air; Alkanesulfonates; Biological; Biological Assay; Birth; Case-Control Studies; Cell physiology; Cells; Chemicals; Child; China; Chromatin; Cities; Country; Data; Developed Countries; Developing Countries; Development; Development Plans; Diet; Disease Outbreaks; Dust; Economic Development; Endocrine; Enrollment; Environment; Environmental Exposure; Environmental Health; Environmental Pollutants; Environmental Pollution; Epigenetic Process; Exposure to; Female; Fetal Development; Fetal Growth; Fetal health; Foundations; Functional disorder; Future; Genetic Transcription; Goals; Government Agencies; Grant; Growth; Health; Health Personnel; Health Policy; High Risk Woman; Household; Household Products; Human; Hypothyroidism; Industrial Product; Industrialization; Industry; Infrastructure; Institution; Interdisciplinary Study; International; Investigation; Knowledge; Laboratories; Lead; Life; Link; Maintenance; Malignant Neoplasms; Manufacturer Name; Maternal Exposure; Maternal Health; Maternal and Child Health; Maternal-fetal medicine; Mentors; Mentorship; Methods; Modification; Molecular Biology; Morbidity - disease rate; Mothers; Mus; Newborn Infant; Outcome; Pathway interactions; Perinatal Epidemiology; Perinatal Exposure; Phase; Pilot Projects; Placenta; Policies; Positioning Attribute; Pregnancy; Pregnant Women; Prevalence; Production; Property; Public Health; Regulation; Reporting; Research; Research Design; Research Personnel; Resources; Risk; Risk Factors; Scientist; Soil; Structure; Surface; Therapeutic; Thyroid Gland; Thyroid Hormones; Thyrotropin; Thyroxine; Time; Toxic effect; Training; Umbilical Cord Blood; Vulnerable Populations; Water; Woman; Work; adverse outcome; adverse pregnancy outcome; base; bioaccumulation; biological research; career; career development; cohort; cost; cost effective; cytotrophoblast; design; didactic education; drinking water; epidemiology study; experience; exposed human population; fetal; genome-wide; global health; immunoregulation; improved; innovation; low and middle-income countries; mortality; multidisciplinary; novel; pregnancy hypertension; pregnant; programs; prospective; recruit; reproductive; reproductive development; reproductive epidemiology; sample collection; trend; trophoblast; water solubility

Effects of PFBS exposure on adverse pregnancy outcomes and fetal development. Perfluorobutane sulfonate (PFBS) is a new chemical widely used in industrial and household products and its persistence, bioaccumulation and toxic properties has been reported. The scientific aims of this proposal are based on the toxicity of PFBS and our preliminary findings that exposure to PFBS can lead to pregnancy- induced hypertension (PIH) and altered maternal and fetal thyroid hormone levels in a Shanghai Birth Cohort (SBC) led by my primary mentor, Dr. Jun Jim Zhang. The prevalence of PIH (~10%) is high in China and PIH- related complications are still threatening maternal and fetal life and health worldwide due to the lack of efficient therapeutic methods. Epidemiology studies have pointed to a thyroid-related disease outbreak in China, especially women are at higher risk of developing hypothyroidism (~17%). Proper thyroid hormone levels are critical for fetal growth and maintaining pregnancy. Environmental exposures including PFBS can contribute to these adverse outcomes. Therefore, the major aim of this proposal is to investigate the effect of maternal exposure to PFBS on the risk of PIH and maternal and cord blood levels of thyroid hormones in Shanghai. We also propose to investigate the underline mechanisms of these findings. A key innovation is that we will answer critical and novel epidemiological and biological research questions. The molecular biology assays for studying mechanisms are innovative, especially the genome-wide chromatin accessibility which is a novel and the most advanced approach to study epigenetics. Successful completion of these aims builds on my expertise (strong molecular biology training and research experiences in maternal fetal medicine) and extends it to exposure assessment and reproductive and perinatal epidemiology in a global research setting that requires additional training and mentorship. I will attain the necessary expertise by working with experts in the relevant fields, through formal course work, structured mentored training and laboratory work. This project will take advantage of the available infrastructure in Shanghai through the highly respected LMIC research institution that will enable me to establish a pregnancy cohort of 6,500-10,000 women and follow the newborns up to two years at a cost effective efficient manner. This grant, beyond providing the necessary training to me to be established as an independent international researcher, will address important gaps in evidence on the effects of PFBS exposure on maternal and child health, and will provide a resource for future studies.

PFBS暴露对不良妊娠结局和胎儿发育的影响。 全氟丁烷磺酸盐（PFB）是一种新的化学物质，广泛用于工业和家用产品及其 据报道，持久性，生物积累和有毒特性。该提议的科学目的是 基于PFB的毒性和我们的初步发现，暴露于PFB会导致怀孕 - 上海出生队列中的诱导高血压（PIH）和孕产妇和胎儿甲状腺激素水平改变 （SBC）由我的主要导师Jun Jim Zhang博士领导。 PIH的患病率（约10％）在中国和PIH- 由于缺乏 有效的治疗方法。流行病学研究表明，甲状腺相关疾病暴发 中国，尤其是妇女患甲状腺功能减退症的风险更高（约17％）。适当的甲状腺激素 水平对于胎儿生长和维持怀孕至关重要。包括PFB在内的环境暴露可以 有助于这些不良结果。因此，该提议的主要目的是调查 孕产妇暴露于PFB上，甲状腺激素的PIH，母体和脐带血水平 上海。我们还建议研究这些发现的下划线机制。一个关键创新是 我们将回答关键和新颖的流行病学和生物学研究问题。分子生物学 研究机制的测定是创新的，尤其是全基因组染色质可及性，这是一种 研究表观遗传学的新颖和最先进的方法。这些目标成功完成 我的专业知识（强大的分子生物学培训和孕产妇胎儿医学的研究经验）和 将其扩展到全球研究环境中的暴露评估和生殖和围产期流行病学 这需要额外的培训和指导。我将通过与专家合作来获得必要的专业知识 相关领域，通过正式的课程工作，结构化指导的培训和实验室工作。这个项目 将通过备受尊敬的LMIC研究来利用上海的可用基础设施 该机构将使我能够建立一个由6,500-10,000名妇女组成的怀孕队列，并跟随新生儿 长达两年以具有成本效益的方式。这笔赠款，除了向我提供必要的培训之外 作为独立国际研究员的建立，将解决有关的重要差距 PFBS暴露对孕产妇和儿童健康的影响，并将为将来的研究提供资源。