Examining Epidemiology of Folate Status Attributable to Adolescent Alcohol Use

检查青少年饮酒导致的叶酸状况的流行病学

基本信息

批准号：
9924562
负责人：
Julie May Croff
金额：
$ 35.57万
依托单位：
OSU CENTER FOR HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至 2022-09-05
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9924562
关键词：
18 year old 19 year old Abruptio Placentae Acute Address Adolescent Adult Affect African American Age Alcohol consumption Alcoholic Intoxication Alcoholism Alcohols Anencephaly and spina bifida X linked Behavior Behavioral Birth Blood Blood alcohol level measurement Cereals Childbirth Childhood Collection Color Communication Communities Conceptions Congenital Abnormality Consumption Data Devices Diet Diet Habits Dose Epidemiology Erythrocytes Ethnic Origin Ethnic group Etiology Event Excretory function Exhibits Face Family Female Female Adolescents Folic Acid Folic Acid Deficiency Food Frequencies Future Goals Grain Heavy Drinking Hepatic High School Student Home environment Hour Impairment Ingestion Intake Intestinal Absorption Kidney Knowledge Latina Latino Link Literature Low Birth Weight Infant Methods Monitor Multivitamin Neural Tube Defects Not Hispanic or Latino Nutrient Outcome Participant Physiological Play Pre-Eclampsia Pregnancy Premature Birth Prevention program Public Health Race Reporting Research Risk Role Sampling Serum Serum Folate Level Spinal Dysraphism Spontaneous abortion Spottings Supplementation Teenagers Telephone Interviews Time Variant Vitamins Woman adverse outcome adverse pregnancy outcome aged alcohol behavior alcohol misuse alcohol use initiation autism spectrum disorder base binge drinking biobehavioral measurement child bearing childhood adversity cognitive function cohort community based participatory research drinking behavior epidemiology study ethnic disparity ethnic diversity experience food consumption fortification girls health disparity innovation longitudinal design offspring problem drinker prospective racial and ethnic racial and ethnic disparities racial disparity racial minority recruit stillbirth underage drinking young adult young woman

项目摘要

Heavy alcohol consumption among adolescents is a fundamental public health threat. There is evidence that heavy alcohol use and alcoholism impair intestinal absorption of folate (vitamin B9), and promotes renal and hepatic folate excretion. Therefore, adolescent girls may face additional risks from heavy alcohol consumption. Inadequate folate status contributes to a host of poor birth outcomes and adverse consequences later in childhood. The proposed prospective epidemiological study will recruit a stratified quota sample of White, African American and Latina (N=455) adolescent girls aged 14 - 18 years. Participants will be monitored over a 4-week period with assessments including weekly collecting of dried blood spot samples (to monitor folate) and continuous transdermal assessment of blood alcohol level. Collected data will be used to achieve three primary specific aims: 1) delineate racial and ethnic variation in the frequency and intensity of alcohol intoxication over time among 14-18 year-old girls, controlling for important familial influences on alcohol use; 2) describe racial and ethnic variation in folate status over time, controlling for dietary habits and important familial influences; and 3) delineate variation in folate status by alcohol intoxication, and determine if folate status is depleted following heavy episodic drinking events. Accomplishing these aim is significant because there are persistent racial and ethnic disparities in poor birth outcomes among women of color, and the role of earlier alcohol behavior in these disparities is ambiguous. This project therefore addresses a critical gap in the literature by expanding knowledge about the potential role heavy alcohol use and subsequent implications for folate status may play in creating racial and ethnic inequities in poor birth outcomes including birth defects. The proposed study is innovative in its prospective, community-based design, its focus on adolescent girls, its objective assessment of alcohol use through continuous transdermal assessment, and its rigorous field assessments of serum folate through the collection of dried blood spot samples. Accomplishing the goals of this study will allow for targeted identification of potential causes of several pregnancy-related problems and birth defects. Such information can be helpful in reducing health disparities related to pregnancy and childbirth.

青少年大量饮酒是一种基本的公共卫生威胁。有证据表明大量的酒精使用和酒精中毒会损害叶酸的肠道吸收（维生素B9），并促进肾脏和肝叶酸排泄。因此，青春期女孩可能会面临大量饮酒的额外风险。后来童年。拟议的前瞻性流行病学研究将招募白色的分层配额样本，非裔美国人和拉丁裔（n = 455）年龄14-18岁的青少年女孩。参与者将被监视一个为期4周的评估，包括每周收集干血点样品（以监测叶酸）和血液酒精水平的连续经皮评估。收集的数据将用于实现三个主要特定目的：1）列出酒精频率和强度的种族和种族变化随着时间的流逝，14-18岁的女孩中的陶醉，控制着对饮酒的重要影响； 2）描述叶酸状况随时间的种族和种族变化，控制饮食习惯和重要家族影响； 3）通过醉酒中介绍叶酸状况的变化，并确定叶酸状态是否为大规模的情节饮酒事件耗尽。完成这些目标是重要的，因为有有色妇女的出生结果不佳的种族和种族差异持续存在，而早期的作用这些差异的酒精行为是模棱两可的。因此，该项目解决了通过扩大有关重量饮酒的潜在作用的知识以及随后对叶酸状况可能在造成不良出生结果（包括先天缺陷）的种族和种族不平等方面发挥作用。拟议的研究在其前瞻性，基于社区的设计，关注青少年女孩，其专业方面具有创新性通过连续的透皮评估及其严格的领域对酒精使用的客观评估通过收集干血点样品的血清叶酸评估。实现目标这项研究将允许有针对性地识别几个与妊娠有关问题的潜在原因，并且出生缺陷。这些信息可能有助于减少与怀孕和分娩有关的健康差异。