Telluride Workshop on Challenges in RNA Structural Modeling and Design

关于 RNA 结构建模和设计挑战的 Telluride 研讨会

• 批准号: 8779815
• 负责人: Anna Marie Pyle
• 金额: $ 0.5万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-11 至 2017-07-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8779815
• 关键词: Address; Archives; Area; Biological Process; Catalysis; Cell physiology; Collaborations; Communication; Computing Methodologies; Congresses; Databases; Discipline; Educational workshop; Engineering; Experimental Models; Feedback; Gene Expression; Genomics; Knowledge; Molecular; Outcome; Participant; Play; Progress Reports; RNA; Resolution; Role; Scientist; Simulate; Statistical Methods; Structural Models; Structure; United States National Institutes of Health; Work; design; frontier; improved; innovation; mathematical methods; meetings; model design; novel; novel strategies; practical application; public health relevance; success; symposium; working group

DESCRIPTION (provided by applicant): The heightened appreciation for the central role of RNA molecules in all cellular processes - from catalysis to control of gene expression to cellular differentiation - combined with the practical applications of synthetic RNAs in biomedicine and biomolecular engineering have raised new challenges regarding RNA structure analysis, prediction, and design to both experimental and theoretical scientists. These challenges have produced many innovative approaches, including interdisciplinary efforts, to analyze, predict, simulate, and design RNA molecules. While many successes have been reported, progress in the field has been hampered by limited experimental resolution and an incomplete understanding of RNA tertiary structure, especially for large RNAs. Though RNA structure is believed to be hierarchical, the difficult problem of understanding and predicting its tertiary structure from its primary as well as secondary structure remains unsolved in general. In addition, some database issues and limited coordination of RNA archives have emerged. To advance this important scientific frontier, we will hold TSRC meetings in Summers 2014 and 2016 to bring leading experimentalists and modelers to discuss and advance the field. We aim to create a core working group to bring together scientists working on both the genomic and molecular levels of RNA using novel experimental, mathematical, statistical, and computational methods. By familiarizing scientists from disparate disciplines with the challenges, and presenting current efforts, advances, and ideas, we hope to catalyze new approaches and collaborations in this important field, identify gaps in knowledge and areas for progress, and address these gaps after the first meeting via focused problems by the second meeting in 2016. Support by the NIH will help not only improve the workshop, but also provide NIH direct feedback on the participants' dialog and outcomes via resulting meeting reports and direct communications.

描述（由申请人提供）：对 RNA 分子在所有细胞过程（从催化、基因表达控制到细胞分化）中的核心作用的高度认识，加上合成 RNA 在生物医学和生物分子工程中的实际应用，提出了新的挑战为实验和理论科学家提供有关 RNA 结构分析、预测和设计的信息。这些挑战催生了许多创新方法，包括跨学科的努力来分析、预测、模拟和设计 RNA 分子。尽管已有许多成功的报道，但该领域的进展受到有限的实验分辨率和对 RNA 三级结构（尤其是大 RNA）的不完全理解的阻碍。尽管RNA结构被认为是分层的，但从其一级和二级结构理解和预测其三级结构的难题总体上仍未解决。此外，还出现了一些数据库问题和 RNA 档案协调有限的问题。为了推进这一重要的科学前沿，我们将在 2014 年和 2016 年夏季举办 TSRC 会议，邀请领先的实验学家和建模者来讨论和推进该领域的发展。我们的目标是创建一个核心工作组，将使用新颖的实验、数学、统计和计算方法研究 RNA 基因组和分子水平的科学家聚集在一起。通过让不同学科的科学家熟悉挑战，并介绍当前的努力、进展和想法，我们希望促进这一重要领域的新方法和合作，找出知识差距和需要进展的领域，并在第一次会议后解决这些差距通过 2016 年第二次会议的重点问题。NIH 的支持不仅有助于改进研讨会，而且还通过最终的会议报告和直接沟通，为 NIH 提供有关参与者对话和结果的直接反馈。