Stephenson Cancer Center - Cancer Center Support Grant

史蒂芬森癌症中心 - 癌症中心支持补助金

• 批准号: 9924260
• 负责人: ROBERT S. MANNEL
• 金额: $ 203.13万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9924260
• 关键词: Address; American Indians; Benchmarking; Biometry; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Catchment Area; Clinical; Clinical Data; Clinical Protocols; Clinical Trials; Cytometry; Data; Development; Diagnosis; Direct Costs; Disease; Education; Enrollment; Environment; Environment Design; Foundations; Funding; Goals; Health Professional; Health Technology; Incidence; Intervention; Leadership; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Medical Research; Mission; Molecular Biology; Monitor; NCI-Designated Cancer Center; Nature; Newly Diagnosed; Oklahoma; Oncology; Pathology; Patient-Focused Outcomes; Patients; Peer Review; Physicians; Population; Prevention; Privatization; Protocols documentation; Reporting; Research; Research Design; Research Personnel; Research Training; Resource Sharing; Rural; Safety; Science; Secure; Services; Source; Statutes and Laws; Structure; Tissues; Training; Universities; base; cancer education; cancer health disparity; cancer prevention; cancer research center director; career; data management; high standard; mHealth; member; mortality; multidisciplinary; next generation; organizational structure; pre-clinical; programs; recruit; standard of care; translational cancer research; treatment research; treatment trial

OVERALL – ABSTRACT Oklahoma currently ranks 7th highest among all states for cancer mortality rates, and 2nd in cancer incidence and mortality rates among the 15 states currently without an NCI-designated cancer center. To address this cancer burden, the State passed bipartisan-supported legislation in 2001, directing the University of Oklahoma to create an academic cancer center that would provide statewide leadership in cancer education, prevention, treatment and research. Acting on this mandate, the University established the Stephenson Cancer Center (SCC), a matrix-based academic cancer center with a mission of reducing the burden of cancer in Oklahoma, a catchment area underserved by NCI-designated cancer centers. An essential partner in advancing this mission is the Oklahoma Medical Research Foundation (OMRF), the SCC's proposed consortium partner. Under the leadership of Robert Mannel, MD, who was appointed Director in 2006, the SCC has secured institutional and other commitments totaling $383.7 million of state, university and philanthropic dollars over the past ten years, which have been used to recruit new cancer researchers and oncology physicians, add new physical space, and develop formal research programs and new shared resources. The level of support for the SCC constitutes the largest public – private biomedical initiative ever launched in the State and has resulted in an academic cancer center that has achieved the following benchmarks during the reporting period (CY2016):  $18,371,115 in overall funding base (peer-reviewed, cancer-relevant) (direct costs).  $8,981,794 in NCI research and training funding (direct costs).  $34,234,985 in total funding (direct costs).  96 full and associate members, representing 32 different academic departments.  278,609 sf. of total physical space (research, clinical, administrative).  $33.1 million in annual discretionary funds under the control of the SCC Director.  2,727 newly diagnosed and treated patients, with 612 enrollments on interventional treatment trials. The SCC has developed an organizational structure and environment designed to promote transdisciplinary, team-based science, move ideas along the translational continuum and stimulate research that impacts the SCC catchment area. This structure includes three formal research programs: Preclinical Translational Cancer Research (PTCR), Gynecologic Cancers (GC) and Cancer Prevention and Control (CPC). SCC member research is supported by four formal shared resource facilities: Biostatistics and Research Design, Molecular Biology and Cytometry Research, Tissue Pathology and Mobile Health Technology. Centralized Clinical Protocol and Data Management, Data and Safety Monitoring, and Protocol Review and Monitoring functions oversee and support the SCC's robust clinical trials program.

总体 - 抽象 目前，俄克拉荷马州在所有州的癌症死亡率中排名第七，癌症发病率排名第二 目前没有NCI指定的癌症中心的15个州的死亡率。解决这个问题 癌症伯恩（Cancer Burnen），该州于2001年通过了两党支持的立法，指导俄克拉荷马大学 建立一个学术癌症中心，该中心将在癌症教育，预防，预防中提供全州领导 治疗和研究。根据这一任务，大学建立了斯蒂芬森癌症中心 （SCC），一个基于基质的学术癌症中心，其使命是减少俄克拉荷马州的癌症的烧伤 NCI指定的癌症中心服务不足。推进这项任务的重要合作伙伴 是俄克拉荷马州医学研究基金会（OMRF），SCC的拟议财团合作伙伴。 在2006年被任命为董事的医学博士罗伯特·曼内尔（Robert Mannel）的领导下，SCC已确保 机构和其他承诺，总计3.837亿美元的州，大学和慈善资金 过去的十年，用于招募新的癌症研究人员和肿瘤医师，添加了新的 物理空间，并制定正式的研究计划和新的共享资源。对 SCC构成了该州有史以来最大的公共生物医学倡议，并导致 在报告期间（CY2016）实现了以下基准的学术癌症中心： $ 18,371,115的总体资金基础（经过同行评审，与癌症相关）（直接费用）。 NCI研究和培训资金（直接费用）$ 8,981,794。 $ 34,234,985的总资金（直接费用）。 96名完整和同学，代表32个不同的学术部门。 278,609平方英尺。总体空间（研究，临床，行政）。 在SCC董事的控制下，每年拨款3310万美元。 有2,727名新诊断和治疗的患者，有612例介入治疗试验。 SCC开发了一种组织结构和环境，旨在促进跨学科， 基于团队的科学，沿翻译连续体的思想移动思想，并刺激影响的研究 SCC集水区。该结构包括三个正式研究计划：临床前翻译癌 研究（PTCR），妇科癌症（GC）和癌症预防与对照（CPC）。 SCC成员 研究得到四个正式共享资源设施的支持：生物统计学和研究设计，分子 生物学和细胞术研究，组织病理学和移动卫生技术。集中临床 协议和数据管理，数据和安全监控以及协议审查和监视功能 监督和支持SCC的强大临床试验计划。