Subfertility and Assisted Conception Study of Parent and Child Health Outcomes

生育力低下和亲子健康结果辅助受孕研究

基本信息

批准号：
9920765
负责人：
Hafsatou Diop
金额：
$ 91.73万
依托单位：
DARTMOUTH-HITCHCOCK CLINIC
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-06-17 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9920765
关键词：
1 year old 4 year old Acute Admission activity Affect Age Ambulatory Care Anxiety Applications Grants Area Assisted Reproductive Technology Asthma Birth Birth Certificates Blood Transfusion Child Child Health Childhood Chronic lung disease Clinic Companions Conceptions Congenital Abnormality Control Groups Data Data Sources Databases Development Diabetes Mellitus Diagnosis Diagnostic Disease Early Intervention Emergency department visit Event Family Fathers Fertility Fetal Death Foundations Gestational Diabetes Grant Health Health Care Costs Heart Diseases Hospital Costs Hospitals Hypertension Immune System Diseases Infant Health Infertility Inflammatory Information Systems Insurance Insurance Coverage Life Link Low Birth Weight Infant Massachusetts Maternal Age Measures Medical Mental Depression Modality Morbidity - disease rate Mothers Neonatal Outcome Outcome Measure Outpatients Parents Pediatric Intensive Care Units Pharmaceutical Preparations Population Postpartum Period Pre-Eclampsia Pregnancy Pregnancy Outcome Premature Birth Procedures Recording of previous events Records Reporting Sample Size Series Small for Gestational Age Infant Societies Specialist Study Subject Surgical complication System Time Tube United States Uterus Visit Woman Women&apos s Group Women&apos s Health base child bearing cohort comparison group cost cost estimate data registry diminished ovarian reserve early childhood endometriosis feeding health of the mother high risk hospital readmission idiopathic infertility infancy infertility treatment innovation intervention program longitudinal database male men neonatal period neoplasm registry outpatient programs perinatal health population based pregnancy hypertension public health relevance repository reproductive study population subfertility

项目摘要

DESCRIPTION (provided by applicant): Subfertility, defined as delayed time-to-conception, affects an estimated 12% of women of reproductive age. The use of fertility-enhancing therapies, including assisted reproductive technologies (ART), has risen steadily in the United States due to several factors, including childbearing at older maternal ages and increasing insurance coverage. Prior studies of women's and children's health after ART have been limited by small sample sizes, non-US populations, or ART treatments performed more than a decade ago, and the lack of appropriate control groups. An important understudied area is that of non-ART fertility treatments and the perinatal, infant, and child health outcomes of these pregnancies. Our original pair of grants was the first population-based analysis of women's and children's health after ART to be conducted in the US. These studies, which had the unique strength of including a non-ART-treated subfertility comparison group, yielded a series of analyses suggesting that underlying subfertility, rather than the treatment modality, is the foundation for most maternal and child morbidity. In this renewal, we will expand this understanding through increased information on subfertility-related diagnoses, underlying non-subfertility medical conditions, non-ART treatment parameters, and outcome measures present in the All Payers Claims Database, as well as inclusion of new information on fathers. We will evaluate the health of mothers during pregnancy and for five years post-delivery, and their children through age four. The study population will include all Massachusetts women who delivered pregnancies between 2004 and 2011 (our original birth cohort) and their children, and will add study subjects who delivered between 2012 and 2017. The total study population will include more than one million families. Reference groups will include ART and non-ART pregnancies with only male factor infertility, and pregnancies without indicators or treatment of subfertility. The study aims and hypotheses are: Aim 1: To evaluate the effect of maternal subfertility diagnoses on long-term health; Hypothesis: Women with a history of subfertility diagnoses, independent of treatment, have higher risks of compromised health outcomes compared to women without indicators or treatment of subfertility; Aim 2: To evaluate the health of children born to women and men with subfertility diagnoses; Hypothesis: Children born to women and/or men with subfertility diagnoses, independent of treatment, have a higher risk of compromised health outcomes compared to children born to women without indicators of subfertility; and Aim 3: To develop a cost-of-subfertility measure for women and their children; Hypothesis: Women with a history of subfertility-related diagnoses and their children have higher healthcare costs compared to their counterparts without indicators or treatment of subfertility.

描述（通过应用程序证明）：定义为延迟到概念的差异，影响了估计使用增强疗法的12％，包括辅助生殖技术（ART），都在稳步上升，因为这是由于在任何因素上，均在联合的因素中稳步上升在旧样本中，将育儿的育儿限制在少量的情况下。对艺术后的妇女和儿童健康的分析，以独特的力量进行，包括包括未经艺术治疗的替代性比较一系列分析，表明属于大多数母亲和儿童发病率的基础，而不是治疗方式，而不是治疗方式。我们将扩大与Fatherity相关的信息的理解，这些信息是基本的非补充医疗分区，非ART治疗参数以及所有付款人索赔数据库中的结果指标。在送达后五年的母亲中，他们的四岁妇女妇女妇女妇女妇女妇女妇女妇女妇女妇女妇女的妇女将在2017年之间进行。米勒（Mille）的参考群体包括男性不育的非艺术妊娠，而没有指标或治疗的妊娠。 M健康：与治疗的史上，具有差异性的妇女具有更高的健康风险。独立于治疗，对儿童的健康状况较高，而没有指标的妇女及其妇女的妇女；与他们的对应物相比，没有指标或治疗副不动。

项目成果

期刊论文数量（23）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Contributions to prematurity of maternal health conditions, subfertility, and assisted reproductive technology.

DOI：
10.1016/j.fertnstert.2020.03.036
发表时间：
2020-10
期刊：
Fertility and sterility
影响因子：
6.7
作者：
Stern JE;Liu CL;Hwang SS;Dukhovny D;Diop H;Cabral H
通讯作者：
Cabral H

The impact of single-step and sequential embryo culture systems on obstetric and perinatal outcomes in singleton pregnancies: the Massachusetts Outcomes Study of Assisted Reproductive Technology.

DOI：
10.1016/j.fertnstert.2022.03.005
发表时间：
2022-06
期刊：
FERTILITY AND STERILITY
影响因子：
6.7
作者：
Sacha, Caitlin R.;Gopal, Daksha;Liu, Chia-Ling;Cabral, Howard R.;Stern, Judy E.;Carusi, Daniela A.;Racowsky, Catherine;Bormann, Charles L.
通讯作者：
Bormann, Charles L.

Factors associated with increased odds of cesarean delivery in ART pregnancies.

DOI：
10.1016/j.fertnstert.2018.04.032
发表时间：
2018-08
期刊：
Fertility and sterility
影响因子：
6.7
作者：
Stern JE;Liu CL;Cabral HJ;Richards EG;Coddington CC;Missmer SA;Diop H
通讯作者：
Diop H

Association of maternal fertility status and receipt of fertility treatment with healthcare utilization in infants up to age four.

DOI：
10.1038/s41372-021-01003-y
发表时间：
2021-10
期刊：
Journal of perinatology : official journal of the California Perinatal Association
影响因子：
0
作者：
Dukhovny D;Hwang SS;Gopal D;Cabral HJ;Diop H;Stern JE
通讯作者：
Stern JE

Assisted reproductive technology treatment increases obstetric and neonatal risks over that of the underlying infertility diagnosis.

DOI：
10.1016/j.fertnstert.2022.02.009
发表时间：
2022-06
期刊：
FERTILITY AND STERILITY
影响因子：
6.7
作者：
Stern, Judy E.;Liu, Chia-Ling;Cui, Xiaohui;Cabral, Howard J.;Farland, Leslie, V;Coddington, Charles;Diop, Hafsatou
通讯作者：
Diop, Hafsatou