Understanding the contribution of poor oral health to sarcopenia in older age and underlying mechanisms using UK and US cohort studies

使用英国和美国队列研究了解口腔健康状况不佳对老年肌少症的影响及其潜在机制

• 批准号: 9917763
• 负责人: Sheena Esther Ramsay
• 金额: $ 10.51万
• 依托单位: UNIVERSITY OF NEWCASTLE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9917763
• 关键词: Address; Age; Aging; Biological Markers; Body Composition; British; Chronic; Cohort Studies; Communities; Country; Cross-Sectional Studies; Data; Data Analyses; Dental; Dentures; Development; Diet; Dietary Factors; Dietary Intervention; Dietary Practices; Early identification; Elderly; Epidemiology; Goals; Health; Health Status; Heart; Hospitalization; Incidence; Inflammation; Inflammatory; Intervention; Investigation; Lead; Longitudinal Studies; Mastication; Measures; Mediating; Mediator of activation protein; Micronutrients; Muscular Atrophy; Nutritional Study; Older Population; Oral health; Outcome; Participant; Pathway interactions; Periodontal Diseases; Play; Population; Population Study; Population trends; Public Health; Research; Risk; Risk Factors; Role; Time; Tooth Loss; Xerostomia; adverse outcome; age related; age-related muscle loss; base; clinical care; cohort; cytokine; dietary supplements; disability; follow-up; frailty; improved; multidisciplinary; muscle form; novel; nutrition; population based; prevent; sarcopenia; Address; Age; Aging; Biological Markers; Body Composition; British; Chronic; Cohort Studies; Communities; Country; Cross-Sectional Studies; Data; Data Analyses; Dental; Dentures; Development; Diet; Dietary Factors; Dietary Intervention; Dietary Practices; Early identification; Elderly; Epidemiology; Goals; Health; Health Status; Heart; Hospitalization; Incidence; Inflammation; Inflammatory; Intervention; Investigation; Lead; Longitudinal Studies; Mastication; Measures; Mediating; Mediator of activation protein; Micronutrients; Muscular Atrophy; Nutritional Study; Older Population; Oral health; Outcome; Participant; Pathway interactions; Periodontal Diseases; Play; Population; Population Study; Population trends; Public Health; Research; Risk; Risk Factors; Role; Time; Tooth Loss; Xerostomia; adverse outcome; age related; age-related muscle loss; base; clinical care; cohort; cytokine; dietary supplements; disability; follow-up; frailty; improved; multidisciplinary; muscle form; novel; nutrition; population based; prevent; sarcopenia

PROJECT SUMMARY Population trends in aging present public health challenges in countries such as the USA and UK. Consequently, age-related health conditions such as sarcopenia (loss of muscle mass) are becoming increasingly prevalent. Oral health problems also increase dramatically with age, particularly tooth loss, periodontal disease, dry mouth, denture-related problems and chewing difficulties. Poor oral health has been implicated as a risk factor for sarcopenia. However, the extent to which and what particular oral health markers contribute to an increased risk of sarcopenia is not well-established. Moreover, the pathways or mechanisms by which oral health might influence sarcopenia are poorly understood. Current research is mostly from studies that are cross-sectional or have limited measures of sarcopenia and oral health in older populations. Such studies are not able to establish the contribution of oral health markers to the development of sarcopenia. To address these scientific evidence gaps, we aim to utilise data from two unique well-characterised cohort studies in the UK and USA. Our overarching goal is to investigate the contribution of oral health to the development of sarcopenia, and to understand the mechanisms underlying this relationship. Our research objectives are to: 1) determine the extent to which markers of poor oral health (periodontal disease, tooth loss, dry mouth, denture problems, chewing difficulties) are associated with incidence of sarcopenia over a 6-year follow-up; 2) determine the role of dietary factors as potential mechanisms underlying the association of poor oral health with incidence of sarcopenia; and 3) determine the role of inflammation as mediators of the association of poor oral health with incidence of sarcopenia. These will be achieved through secondary data analyses of two large population-based longitudinal studies of older people in the UK and USA, which are uniquely-placed for these investigations. These studies have detailed data on oral health, dietary factors, inflammation, as well as sarcopenia over time. The British Regional Heart Study is the only such longitudinal study of older people in the UK. The study comprises participants from 24 towns across Britain, followed-up at age 71-92 years in 2012 and at 77- 98 years. The US Health, Aging and Body Composition Study offers complementary data in a population-based study of older people from Memphis and Pittsburgh followed-up from age 71-80 years. These investigations based, on novel conceptual hypotheses and cross-country comparisons in UK and US studies, will significantly advance our understanding of the role that oral health plays in an important geriatric condition such as sarcopenia. The goal of this research is to provide the scientific basis for better identification and management of oral health conditions in older people, and to identify targets for interventions to reduce sarcopenia. These efforts are ultimately aimed at better health of older people.

项目摘要 衰老的人口趋势在美国和英国等国家提出了公共卫生挑战。 因此，与年龄相关的健康状况（例如肌肉减少症（肌肉质量））正在变得 越来越普遍。口腔健康问题也随着年龄的年龄，尤其是牙齿脱落而大大增加 牙周疾病，口干，与牙齿有关的问题和咀嚼困难。口腔健康状况不佳 被认为是肌肉减少症的危险因素。但是，在哪个特定口头的程度和 健康标志物导致肌肉减少症的风险增加尚未确立。而且， 口腔健康可能影响肌肉减少症的途径或机制知之甚少。 当前的研究主要来自横截面或对肌肉减少症的措施有限的研究 和老年人的口腔健康。这样的研究无法确定口腔健康的贡献 肌肉减少症发展的标记。 为了解决这些科学的证​​据差距，我们旨在利用两个独特的特征的数据 英国和美国的队列研究。我们的总体目标是调查口腔健康的贡献 为了发展肌肉减少症，并了解这种关系的基础机制。 我们的研究目标是：1）确定口腔健康差的标志的程度（牙周 疾病，牙齿流失，口干，义齿问题，咀嚼困难）与发生率有关 在6年的随访中肌肉减少症； 2）确定饮食因素作为潜在机制的作用 贫穷的口腔健康与肌肉减少症的发生率的关联； 3）确定 炎症是口腔健康与肌肉减少症发生率的介导者。 这些将通过两个基于人群的纵向进行二级数据分析来实现 对英国和美国的老年人的研究，这些研究是这些调查的独特之处。这些 随着时间的流逝，研究有有关口腔健康，饮食因素，炎症以及肌肉减少症的详细数据。 英国地区心脏研究是英国老年人的唯一纵向研究。研究 由来自英国24个城镇的参与者组成，2012年为71-92岁，在77-- 98年。美国的健康，衰老和身体成分研究提供了补充数据 从71-80岁开始，对孟菲斯和匹兹堡的老年人进行了基于人群的研究。 这些调查基于英国的新颖概念假设和越野比较 美国的研究将大大促进我们对口腔健康在重要的重要作用的理解 老年疾病，例如肌肉减少症。这项研究的目的是为科学依据 更好地识别和管理老年人的口腔健康状况，并确定 减少肌肉减少症的干预措施。这些努力最终旨在旨在改善老年人的健康。