Early Environmental Stressors and Emerging Cardiometabolic Risk

早期环境压力源和新出现的心脏代谢风险

• 批准号: 9910419
• 负责人: Alicia S Kunin-Batson
• 金额: $ 65.07万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-21 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9910419
• 关键词: 4 year old; 9 year old; Adult; Affect; Age; Behavioral; Behavioral Model; Biological; Biological Models; Body Composition; Buffers; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Cessation of life; Child; Child Health; Childhood; Chronic; Chronic Disease; Data Collection; Development; Diet; Dietary intake; Disease; Disease Outcome; Dyslipidemias; Economically Deprived Population; Environment; Environmental Risk Factor; Evaluation; Family; Goals; Hair; Health behavior; Heart Diseases; Home environment; Hour; Hydrocortisone; Hypertension; Inflammation; Intervention; Knowledge; Link; Longitudinal Studies; Low income; Measures; Mediating; Mediator of activation protein; Metabolic; National Heart, Lung, and Blood Institute; Neighborhoods; Obesity; Oxidative Stress; Pathway interactions; Pattern; Physical activity; Physiological; Prevalence; Prevention; Prevention Research; Process; Prospective Studies; Psychosocial Stress; Regulatory Pathway; Risk; Risk Factors; Role; Sampling; Science; Stress; Unhealthy Diet; United States National Institutes of Health; cardiometabolic risk; cardiometabolism; cardiovascular disorder risk; cohort; design; early childhood; effective intervention; environmental stressor; ethnic diversity; experience; high risk; hypothalamic-pituitary-adrenal axis; indexing; middle childhood; obesity in children; prevent; prospective; psychosocial; racial and ethnic; socioeconomic disadvantage; socioeconomics; stressor; temporal measurement; treatment research; tv watching

Project Summary/Abstract Heart disease is a leading cause of death in the US and obesity is an important risk factor. While cardiometabolic diseases have peak prevalence in adulthood, the assessment of cardiometabolic risk processes in childhood is critical in order to define the early causal factors that contribute to the development of chronic disease and to identify potential pathways for prevention. Previous studies have shown that traditional cardiometabolic risk factors (e.g., hypertension) track from childhood into adulthood. Socioeconomic disadvantage and psychosocial stressors have also been linked to obesity in childhood and to later risk of cardiovascular disease. However, a major knowledge gap remains in understanding how environmental, behavioral, and biological contexts interact to influence cardiometabolic risk in the developing child and influence later disease outcomes. The proposed study will examine the relationship between early environmental stressors and emerging cardiometabolic risk by extending a unique cohort of 534 racially/ethnically diverse, predominantly low income children who have been studied longitudinally since they were 2-4 years of age [The NET-Works Trial (U01HD068890; Sherwood/French PIs), part of the COPTR consortium (Child Obesity Prevention and Treatment Research Consortium, NIH/NHLBI/DCVS/PPSP)]. The overall goal of the proposed study is to characterize the emergence of dysregulation in cardiometabolic processes in a high-risk cohort of children at 7-9 years of age, and elucidate the pathways through which early environmental stressors influence cardiometabolic risk. Four existing measurement time points provide rich information about psychosocial stressors in children's homes and neighborhoods, physiological measures of children's stress (cortisol levels from hair samples), and patterns of children's health behavior. New data collection when children are 7-9 years of age will add a comprehensive state-of-the-science cardiometabolic assessment. Specifically, this study will (1) establish and quantify the independent influence of and interaction between home and neighborhood environmental stressors in early childhood on cardiometabolic risk in middle childhood and (2) examine the role of children's health behaviors (i.e., physical activity, dietary intake, and screen time) and cortisol levels in emerging cardiometabolic risk, and determine whether health behaviors and cortisol mediate the relationship between environmental stressors and cardiometabolic risk. This prospective, multi-component approach to measuring early environmental stressors and emerging cardiometabolic risk processes, at a developmental stage when precursors of cardiometabolic disease can begin to be observed but before the manifestation of overt disease, will help us define early causal factors that set the stage for later development of adult chronic conditions.

项目摘要/摘要 心脏病是美国死亡的主要原因，肥胖是重要的危险因素。尽管 心脏代谢性疾病在成年后的峰值患病率，心脏代谢风险的评估 童年过程至关重要，以定义有助于发展的早期因果因素 慢性疾病并确定预防的潜在途径。先前的研究表明 从童年到成年的传统心脏代谢危险因素（例如，高血压）。 社会经济的劣势和社会心理压力源也与童年的肥胖症有关，与 后来患心血管疾病的风险。但是，主要的知识差距仍在理解如何 环境，行为和生物环境相互作用以影响发展中的心脏代谢风险 儿童并影响后来的疾病结果。拟议的研究将检查早期的关系 环境压力源和新兴的心脏代谢风险通过扩展534的唯一队列 自种族/种族多样化，主要是低收入的儿童，他们是纵向研究的 年龄2-4岁[Net-Works试验（U01HD068890; Sherwood/French PIS），COPTR的一部分 财团（儿童肥胖和治疗研究财团，NIH/NHLBI/DCVS/PPSP）]。这 拟议研究的总体目标是表征失调失调的出现 在7-9岁的高危儿童中的心脏代谢过程，并阐明 早期环境压力源会影响心脏代谢风险的途径。四个现有 测量时间点提供了有关儿童家中心理压力源的丰富信息， 邻居，儿童压力的生理测量（皮质醇水平来自头发样品）和模式 儿童的健康行为。儿童7-9岁时的新数据收集将增加一个全面的 最先进的心脏代谢评估。具体而言，这项研究将（1）建立和量化 早期家庭与邻里环境压力之间的独立影响和互动 儿童时期的儿童时期风险和（2）检查儿童健康行为的作用 （即体育锻炼，饮食摄入和筛查时间）以及新兴心脏代谢风险的皮质醇水平， 并确定健康行为和皮质醇是否介导环境之间的关系 压力源和心脏代谢风险。这种前瞻性的多组分方法，用于提早测量 在发育阶段，环境压力源和新兴的心脏代谢风险过程 可以开始观察到心脏代谢疾病的前体，但在明显疾病表现之前， 将有助于我们定义早期因果因素，这为后来发展成人慢性病的发展奠定了基础。

项目成果

Body Mass Index Trajectories and Biomarkers of Cardiometabolic Risk in Children from Low-Income and Racially and Ethnically Diverse Households.

低收入和种族和民族多样化家庭儿童的体重指数轨迹和心脏代谢风险生物标志物。

• DOI: 10.1089/chi.2022.0216
• 发表时间: 2023
• 期刊: Childhood obesity (Print)
• 作者: deBrito,JuniaN;Pereira,MarkA;Kelly,AaronS;Erickson,DarinJ;Sherwood,NancyE;Mason,SusanM;Loth,KatieA;French,SimoneA;Evanoff,NicholasG;Dengel,DonaldR;Kunin-Batson,AliciaS
• 通讯作者: Kunin-Batson,AliciaS

Household Income, Cortisol, and Obesity During Early Childhood: A Prospective Longitudinal Study.

儿童早期的家庭收入、皮质醇和肥胖：一项前瞻性纵向研究。

• DOI: 10.1016/j.jpeds.2022.09.007
• 发表时间: 2023
• 期刊: The Journal of pediatrics
• 作者: Kunin-Batson,AliciaS;Crain,ALauren;Gunnar,MeganR;Kelly,AaronS;Kharbanda,ElyseO;Haapala,Jacob;Seburg,ElisabethM;Sherwood,NancyE;French,SimoneA
• 通讯作者: French,SimoneA