Early Environmental Stressors and Emerging Cardiometabolic Risk

早期环境压力源和新出现的心脏代谢风险

• 批准号: 9910419
• 负责人: Alicia S Kunin-Batson
• 金额: $ 65.07万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-21 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9910419
• 关键词: 4 year old; 9 year old; Adult; Affect; Age; Behavioral; Behavioral Model; Biological; Biological Models; Body Composition; Buffers; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Cessation of life; Child; Child Health; Childhood; Chronic; Chronic Disease; Data Collection; Development; Diet; Dietary intake; Disease; Disease Outcome; Dyslipidemias; Economically Deprived Population; Environment; Environmental Risk Factor; Evaluation; Family; Goals; Hair; Health behavior; Heart Diseases; Home environment; Hour; Hydrocortisone; Hypertension; Inflammation; Intervention; Knowledge; Link; Longitudinal Studies; Low income; Measures; Mediating; Mediator of activation protein; Metabolic; National Heart, Lung, and Blood Institute; Neighborhoods; Obesity; Oxidative Stress; Pathway interactions; Pattern; Physical activity; Physiological; Prevalence; Prevention; Prevention Research; Process; Prospective Studies; Psychosocial Stress; Regulatory Pathway; Risk; Risk Factors; Role; Sampling; Science; Stress; Unhealthy Diet; United States National Institutes of Health; cardiometabolic risk; cardiometabolism; cardiovascular disorder risk; cohort; design; early childhood; effective intervention; environmental stressor; ethnic diversity; experience; high risk; hypothalamic-pituitary-adrenal axis; indexing; middle childhood; obesity in children; prevent; prospective; psychosocial; racial and ethnic; socioeconomic disadvantage; socioeconomics; stressor; temporal measurement; treatment research; tv watching

Project Summary/Abstract Heart disease is a leading cause of death in the US and obesity is an important risk factor. While cardiometabolic diseases have peak prevalence in adulthood, the assessment of cardiometabolic risk processes in childhood is critical in order to define the early causal factors that contribute to the development of chronic disease and to identify potential pathways for prevention. Previous studies have shown that traditional cardiometabolic risk factors (e.g., hypertension) track from childhood into adulthood. Socioeconomic disadvantage and psychosocial stressors have also been linked to obesity in childhood and to later risk of cardiovascular disease. However, a major knowledge gap remains in understanding how environmental, behavioral, and biological contexts interact to influence cardiometabolic risk in the developing child and influence later disease outcomes. The proposed study will examine the relationship between early environmental stressors and emerging cardiometabolic risk by extending a unique cohort of 534 racially/ethnically diverse, predominantly low income children who have been studied longitudinally since they were 2-4 years of age [The NET-Works Trial (U01HD068890; Sherwood/French PIs), part of the COPTR consortium (Child Obesity Prevention and Treatment Research Consortium, NIH/NHLBI/DCVS/PPSP)]. The overall goal of the proposed study is to characterize the emergence of dysregulation in cardiometabolic processes in a high-risk cohort of children at 7-9 years of age, and elucidate the pathways through which early environmental stressors influence cardiometabolic risk. Four existing measurement time points provide rich information about psychosocial stressors in children's homes and neighborhoods, physiological measures of children's stress (cortisol levels from hair samples), and patterns of children's health behavior. New data collection when children are 7-9 years of age will add a comprehensive state-of-the-science cardiometabolic assessment. Specifically, this study will (1) establish and quantify the independent influence of and interaction between home and neighborhood environmental stressors in early childhood on cardiometabolic risk in middle childhood and (2) examine the role of children's health behaviors (i.e., physical activity, dietary intake, and screen time) and cortisol levels in emerging cardiometabolic risk, and determine whether health behaviors and cortisol mediate the relationship between environmental stressors and cardiometabolic risk. This prospective, multi-component approach to measuring early environmental stressors and emerging cardiometabolic risk processes, at a developmental stage when precursors of cardiometabolic disease can begin to be observed but before the manifestation of overt disease, will help us define early causal factors that set the stage for later development of adult chronic conditions.

项目概要/摘要 心脏病是美国的一个主要原因，而肥胖是一个重要的危险因素。尽管 心脏代谢疾病在成年期发病率达到高峰，心脏代谢风险的评估 为了确定有助于发展的早期因果因素，童年时期的过程至关重要 慢性疾病并确定潜在的预防途径。先前的研究表明 传统的心脏代谢危险因素（例如高血压）从童年一直持续到成年。 社会经济劣势和社会心理压力也与儿童期肥胖和肥胖有关。 以后有心血管疾病的风险。然而，在理解如何 环境、行为和生物背景相互作用，影响发展中国家的心脏代谢风险 儿童并影响以后的疾病结果。拟议的研究将探讨早期之间的关系 第534章 种族/族裔多样化、主要是低收入儿童，自他们出生以来就一直接受纵向研究 年龄为 2-4 岁 [NET-Works 试验（U01HD068890；Sherwood/French PI），COPTR 的一部分 联盟（儿童肥胖预防和治疗研究联盟，NIH/NHLBI/DCVS/PPSP）]。这 拟议研究的总体目标是描述失调现象的出现 7-9 岁高危儿童群体的心脏代谢过程，并阐明 早期环境压力因素影响心脏代谢风险的途径。现有四个 测量时间点提供了有关儿童家庭和社会心理压力源的丰富信息 社区、儿童压力的生理测量（头发样本中的皮质醇水平）以及行为模式 儿童的健康行为。 7-9岁儿童的新数据收集将添加全面的 最科学的心脏代谢评估。具体来说，本研究将 (1) 建立并量化 早期家庭和邻里环境压力源之间的独立影响和相互作用 儿童期对儿童中期心脏代谢风险的影响，以及（2）检查儿童健康行为的作用 （即体力活动、饮食摄入量和屏幕时间）和皮质醇水平与新出现的心脏代谢风险， 并确定健康行为和皮质醇是否介导环境之间的关系 压力源和心脏代谢风险。这种前瞻性、多成分的早期测量方法 环境压力源和新兴的心脏代谢风险过程，在发育阶段 可以开始观察心脏代谢疾病的先兆，但在明显疾病出现之前， 将帮助我们确定早期因果因素，为成人慢性病的后期发展奠定基础。

项目成果

Body Mass Index Trajectories and Biomarkers of Cardiometabolic Risk in Children from Low-Income and Racially and Ethnically Diverse Households.

低收入和种族和民族多样化家庭儿童的体重指数轨迹和心脏代谢风险生物标志物。

• DOI: 10.1089/chi.2022.0216
• 发表时间: 2023
• 期刊: Childhood obesity (Print)
• 作者: deBrito,JuniaN;Pereira,MarkA;Kelly,AaronS;Erickson,DarinJ;Sherwood,NancyE;Mason,SusanM;Loth,KatieA;French,SimoneA;Evanoff,NicholasG;Dengel,DonaldR;Kunin-Batson,AliciaS
• 通讯作者: Kunin-Batson,AliciaS

Household Income, Cortisol, and Obesity During Early Childhood: A Prospective Longitudinal Study.

儿童早期的家庭收入、皮质醇和肥胖：一项前瞻性纵向研究。

• DOI: 10.1016/j.jpeds.2022.09.007
• 发表时间: 2023
• 期刊: The Journal of pediatrics
• 作者: Kunin-Batson,AliciaS;Crain,ALauren;Gunnar,MeganR;Kelly,AaronS;Kharbanda,ElyseO;Haapala,Jacob;Seburg,ElisabethM;Sherwood,NancyE;French,SimoneA
• 通讯作者: French,SimoneA