The role of impulsive phenotypes on weight trajectories and response to behavioral interventions during pregnancy and the postpartum period

冲动表型对体重轨迹的作用以及怀孕和产后期对行为干预的反应

基本信息

项目摘要

ABSTRACT The perinatal period, defined as the period from pregnancy through the first postpartum year, is a critical time for weight management intervention and provides a unique opportunity to understand factors associated with weight and eating behaviors. In response to PAR-16-304, we propose to leverage our ongoing efforts to evaluate sequences of weight management across the perinatal period by evaluating the contribution of behavioral phenotypes to perinatal obesity. Specifically, we propose to examine the link between impulsive phenotypes and perinatal weight. Impulsive phenotypes are associated with higher body mass index, greater weight gain over time, and poor response to weight management interventions. The effects of impulsive phenotypes on weight changes also are bidirectional. However, the role of impulsive phenotypes on weight trajectories over the perinatal period, and how these phenotypes may affect response to perinatal weight interventions, is unknown. Our work, and that of others, has documented strong links between weight and impulsive phenotypes characterized by: (1) disinhibited behavior, (2) attentional deficits, (3) impulsive decision- making, and (4) cognitive inflexibility, though it remains unclear whether and how these impulsive phenotypes predict weight trajectories and eating behavior over the perinatal period or response to perinatal intervention. Accordingly, we plan to assess these impulsive phenotypes among women with overweight or obesity enrolled in a perinatal weight trial. Women with overweight or obesity before pregnancy are currently being recruited and followed in a sequential multiple assignment trial designed to evaluate sequences of perinatal weight management interventions associated with improved maternal weight and health one year postpartum (R01HL132578). Women are enrolled at the beginning of prenatal care and randomly assigned to intervention that addresses the unique challenges of weight during pregnancy or a comparison condition involving treatment as usual. At delivery, women again are randomized to postpartum weight intervention or treatment as usual. We propose to add behavioral tasks and questionnaire assessments of impulsive phenotypes and eating behaviors to capitalize on the data collected in this parent trial. The specific aims are to (1) examine impulsive phenotypes as predictors of perinatal weight trajectories across the postpartum year, and (2) evaluate relationships among impulsive phenotypes, perinatal interventions and weight loss outcomes and eating behaviors. We also will explore the joint trajectories of weight and impulsive phenotypes from pregnancy through 12-months postpartum. Assessing impulsive phenotypes within a study of perinatal weight intervention will enhance the understanding of behavioral and cognitive factors associated with weight trajectories across the postpartum year. These data will support efforts to personalize weight management interventions and contribute to the development of novel behavioral perinatal interventions to improve longer-term health.
抽象的 围产期是指从怀孕到产后第一年的时期,是一个关键的时期。 体重管理干预的时间,并提供了了解相关因素的独特机会 与体重和饮食行为有关。为了响应 PAR-16-304,我们建议利用我们持续的努力 通过评估以下因素的贡献来评估整个围产期体重管理的顺序: 行为表型对围产期肥胖的影响。具体来说,我们建议检查冲动之间的联系 表型和围产期体重。冲动表型与较高的体重指数、较大的 随着时间的推移,体重增加,并且对体重管理干预措施的反应不佳。冲动的影响 体重变化的表型也是双向的。然而,冲动表型对体重的作用 围产期的轨迹,以及这些表型如何影响对围产期体重的反应 干预措施,未知。我们和其他人的工作已经证明了体重和体重之间的密切联系。 冲动表型的特征是:(1)去抑制行为,(2)注意力缺陷,(3)冲动决策 造成,以及(4)认知僵化,尽管目前尚不清楚这些冲动表型是否以及如何形成 预测围产期的体重轨迹和饮食行为或对围产期干预的反应。 因此,我们计划评估超重或肥胖女性的冲动表型 在围产期体重试验中。目前正在招募怀孕前超重或肥胖的女性 然后进行连续多重分配试验,旨在评估围产期体重序列 与产后一年产妇体重和健康状况改善相关的管理干预措施 (R01HL132578)。妇女在产前护理开始时就被登记并随机分配接受干预 解决怀孕期间体重的独特挑战或涉及的比较条件 照常治疗。分娩时,女性再次被随机接受产后体重干预或治疗 照常。我们建议添加行为任务和冲动表型的问卷评估 饮食行为,以利用本次家长试验中收集的数据。具体目标是 (1) 审查 冲动表型作为产后围产期体重轨迹的预测因素,以及(2) 评估冲动表型、围产期干预和减肥结果之间的关系 饮食行为。我们还将探索怀孕期间体重和冲动表型的联合轨迹 到产后 12 个月。在围产期体重干预研究中评估冲动表型 将增强对与体重轨迹相关的行为和认知因素的理解 产后一年。这些数据将支持个性化体重管理干预措施和 有助于开发新型围产期行为干预措施,以改善长期健康。

项目成果

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MICHELE D LEVINE其他文献

MICHELE D LEVINE的其他文献

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{{ truncateString('MICHELE D LEVINE', 18)}}的其他基金

Optimizing health from pregnancy through one year postpartum: A sequential multiple assignment randomized trial (SMART) of perinatal lifestyle intervention
优化从怀孕到产后一年的健康:围产期生活方式干预的序贯多重分配随机试验 (SMART)
  • 批准号:
    10392312
  • 财政年份:
    2021
  • 资助金额:
    $ 44.4万
  • 项目类别:
The role of impulsive phenotypes on weight trajectories and response to behavioral interventions during pregnancy and the postpartum period
冲动表型对体重轨迹的作用以及怀孕和产后期对行为干预的反应
  • 批准号:
    9516363
  • 财政年份:
    2018
  • 资助金额:
    $ 44.4万
  • 项目类别:
Optimizing health from pregnancy through one year postpartum: A sequential multiple assignment randomized trial (SMART) of perinatal lifestyle intervention
优化从怀孕到产后一年的健康:围产期生活方式干预的序贯多重分配随机试验 (SMART)
  • 批准号:
    9336346
  • 财政年份:
    2016
  • 资助金额:
    $ 44.4万
  • 项目类别:
Optimizing health from pregnancy through one year postpartum: A sequential multiple assignment randomized trial (SMART) of perinatal lifestyle intervention
优化从怀孕到产后一年的健康:围产期生活方式干预的序贯多重分配随机试验 (SMART)
  • 批准号:
    9195238
  • 财政年份:
    2016
  • 资助金额:
    $ 44.4万
  • 项目类别:
Optimizing health from pregnancy through one year postpartum: A sequential multiple assignment randomized trial (SMART) of perinatal lifestyle intervention
优化从怀孕到产后一年的健康:围产期生活方式干预的序贯多重分配随机试验 (SMART)
  • 批准号:
    10020430
  • 财政年份:
    2016
  • 资助金额:
    $ 44.4万
  • 项目类别:
Relationship of Loss of Control Eating to Excessive Gestational Weight Gain
饮食失控与妊娠期体重过度增加的关系
  • 批准号:
    8434025
  • 财政年份:
    2012
  • 资助金额:
    $ 44.4万
  • 项目类别:
Relationship of Loss of Control Eating to Excessive Gestational Weight Gain
饮食失控与妊娠期体重过度增加的关系
  • 批准号:
    8234408
  • 财政年份:
    2012
  • 资助金额:
    $ 44.4万
  • 项目类别:
Relationship of Loss of Control Eating to Excessive Gestational Weight Gain
饮食失控与妊娠期体重过度增加的关系
  • 批准号:
    8620675
  • 财政年份:
    2012
  • 资助金额:
    $ 44.4万
  • 项目类别:
Relationship of Loss of Control Eating to Excessive Gestational Weight Gain
饮食失控与妊娠期体重过度增加的关系
  • 批准号:
    8815956
  • 财政年份:
    2012
  • 资助金额:
    $ 44.4万
  • 项目类别:
Relationship of Loss of Control Eating to Excessive Gestational Weight Gain
饮食失控与妊娠期体重过度增加的关系
  • 批准号:
    9026631
  • 财政年份:
    2012
  • 资助金额:
    $ 44.4万
  • 项目类别:

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