End-to-End Optimization of SPECT Instrumentation, Acquisition, and Reconstruction

SPECT 仪器、采集和重建的端到端优化

• 批准号: 8595309
• 负责人: ERIC C. FREY
• 金额: $ 34.41万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8595309
• 关键词: Address; Arrhythmia; Brain Diseases; Cadmium; Cardiac; Cardiovascular Diseases; Clinical Research; Collimator; Complement; DCNU; Data; Defect; Detection; Development; Diagnosis; Diagnostic Neoplasm Staging; Discipline of Nuclear Medicine; Disease; Dose; Fibrinogen; Financial compensation; Future; Goals; Grant; Heart; Heart Diseases; Heart failure; Human; Image; Individual; Measures; Methods; Modeling; Myocardial; Myocardial perfusion; Noise; Patients; Performance; Perfusion; Physicians; Play; Population; Radiation; Resolution; Role; Scheme; Semiconductors; Series; Signal Transduction; Simulate; Site; Source; Staging; System; Tail; Technetium 99m; Testing; Time; Tracer; Validation; Width; Work; Zinc; base; clinical research site; detector; diagnostic accuracy; image processing; improved; instrumentation; metaiodobenzylguanidine; nerve supply; novel; public health relevance; reconstruction; response; simulation; single photon emission computed tomography; software systems; tool

DESCRIPTION (provided by applicant): Single-Photon Emission Computed Tomography plays an important and well- validated role in the diagnosis and staging of a number of important cardiac diseases, and is widely used and available at many clinical sites in the US and around the world. The most common application has been myocardial perfusion SPECT to evaluate cardiovascular disease. A new and potentially important application is I-123 MIBG SPECT (AdreView) for myocardial innervation imaging. While there has been a great deal of work to develop improved reconstruction methods, and some work to develop optimized instrumentation and acquisition parameters, these have been done largely in isolation of each other. Questions such as: what is the optimal collimator when using collimator response compensation? what is the optimal energy window with scatter compensation?, is it optimal to use the same acquisition time for each projection view?, and is it optimal to use the same acquisition time per patient? have never been addressed. In addition, there are currently a number of dedicated scanners for cardiac imaging that incorporate several novel features to decrease acquisition time. Some of these are based on cadmium zinc telluride semiconductor detectors that provide improved full-width at half maximum energy resolution, but have a more complicated energy response that includes tails extending to low-energies. Other new detector materials such as LaBr with improved energy resolutions are on the horizon. However, energy windows and scatter compensation methods for CZT and LaBr detectors have not been optimized, nor has their benefit on cardiac imaging been rigorously tested. In this grant we propose to use novel, state-of-the art task-based image quality measures and realistic well-validated simulations calibrated by clinical studies to perform comprehensive end-to-end optimization of instrumentation, acquisition, reconstruction, and compensation parameters and methods. We will investigate the tradeoff between these factors and acquisition time/injected dose, allowing physicians to trade image quality for reduced radiation dose. The results would have an immediate impact in providing improved image quality, diagnostic accuracy, and reduced patient dose, while also having a longer term impact by guiding the development of future SPECT systems. The work will also provide validation of novel optimization strategies using projection-domain ideal-observers that handle mismatch between the imaging model used in the reconstruction and the true imaging process.

描述（由申请人提供）：单光子发射计算机断层扫描在许多重要心脏疾病的诊断和分期中发挥着重要且经过充分验证的作用，并且在美国和世界各地的许多临床场所得到广泛使用和使用。世界。最常见的应用是心肌灌注 SPECT 来评估心血管疾病。一个新的、潜在的重要应用是用于心肌神经支配成像的 I-123 MIBG SPECT (AdreView)。虽然在开发改进的重建方法方面做了大量的工作，并且在开发优化的仪器和采集参数方面做了一些工作，但这些工作基本上是相互独立完成的。诸如以下问题：使用准直器响应补偿时最佳准直器是什么？具有散射补偿的最佳能量窗口是多少？每个投影视图使用相同的采集时间是否最佳？每个患者使用相同的采集时间是否最佳？从未被解决过。此外，目前有许多用于心脏成像的专用扫描仪，它们结合了多种新颖的功能来减少采集时间。其中一些基于碲化镉锌半导体探测器，可提供改进的半最大能量分辨率全宽，但具有更复杂的能量响应，包括延伸至低能量的尾部。其他新型探测器材料（例如具有改进能量分辨率的 LaBr）即将出现。然而，CZT 和 LaBr 探测器的能量窗和散射补偿方法尚未优化，它们对心脏成像的好处也未经过严格测试。在这笔资助中，我们建议使用新颖、最先进的基于任务的图像质量测量和经过临床研究校准的真实有效的模拟来对仪器、采集、重建和补偿参数进行全面的端到端优化和方法。我们将研究这些因素与采集时间/注射剂量之间的权衡，使医生能够以图像质量换取减少的辐射剂量。研究结果将对提高图像质量、诊断准确性和减少患者剂量产生直接影响，同时还会通过指导未来 SPECT 系统的开发产生长期影响。这项工作还将使用投影域理想观察器来验证新颖的优化策略，该观察器处理重建中使用的成像模型与真实成像过程之间的不匹配。