TMS-EEG investigation of prefrontal cortical excitability in depression and rTMS treatment response
TMS-EEG 研究抑郁症前额皮质兴奋性和 rTMS 治疗反应
基本信息
- 批准号:9896462
- 负责人:
- 金额:$ 20.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-02-13 至 2022-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
PROJECT SUMMARY
Treatment of Major Depressive Disorder (MDD) is a serious clinical challenge as nearly 50% of depressed
patients do not fully respond to treatment, referred to as Treatment Resistant Depression (TRD). Current
antidepressants take few weeks to work and further, there are no reliable clinical biomarkers available to predict
treatment response which leads to several trial-and-error attempts of different treatment strategies. The two
leading challenges in MDD research are – (i) developing better treatments and (ii) developing noninvasive
clinically useful biomarkers of antidepressant treatment response. The main objective of this award is to
investigate prefrontal cortical excitability as neurobiological mechanisms underlying depression and
antidepressant effect of rTMS in patients with TRD by using concurrent Transcranial Magnetic Stimulation-
Electroencephalography (TMS-EEG). This project uses an innovative research strategy by deploying TMS-EEG
to study cortical excitability in dorsolateral prefrontal cortex in TRD patients at baseline and after intermittent
theta burst stimulation (iTBS), a state-of-the-art FDA approved TRD treatment. For baseline comparison with
patients, demographically matched healthy controls will have TMS-EEG. The project aims will be accomplished
by: 1) Investigating the prefrontal cortical excitability in patients with depression compared with healthy control
subjects; 2) Investigating the effect of iTBS on prefrontal cortical excitability; and 3) Investigating the baseline
dorsolateral prefrontal cortical excitability measures and its relationship to improvements in mood in patients with
TRD. The findings from this study will strengthen our understanding of mechanisms underlying anti-depressant
action and thus facilitate development of non-invasive surrogate markers of antidepressant response to iTBS in
TRD. This work will contribute to: 1) personalized medicine in MDD by establishing markers of treatment
response, 2) understanding rTMS antidepressant effect.
项目摘要
重大抑郁症(MDD)的治疗是严重的临床挑战
患者对治疗没有完全反应,称为抗治疗抑郁症(TRD)。当前的
抗抑郁药需要几周的时间才能工作,而且没有可靠的临床生物标志物可以预测
治疗反应会导致不同的治疗策略的多次反复尝试。两个
MDD研究中的主要挑战是 - (i)开发更好的治疗方法,以及(ii)发展无创的
抗抑郁治疗反应的临床上有用的生物标志物。该奖项的主要目的是
研究前额叶皮质令人兴奋,作为抑郁症和抑郁症的神经生物学机制
通过使用并发的经颅磁刺激 -
脑电图(TMS-EEG)。该项目通过部署TMS-EEG使用创新的研究策略
研究基线和间歇性后TRD患者背外侧前额叶皮层皮质兴奋
Theta爆发刺激(ITB)是最先进的FDA批准的TRD处理。用于基线比较
患者,人口匹配的健康对照将具有TMS-EEG。该项目的目标将实现
作者:1)与健康对照相比,研究抑郁症患者的前额叶皮质刺激性
受试者; 2)研究ITB对前额叶皮质刺激的影响; 3)调查基线
背侧前额叶皮质令人兴奋措施及其与患者与情绪的关系有所改善
trd。这项研究的发现将加强我们对抗抑郁剂基础机制的理解
作用,从而促进抗抑郁反应的非侵入性替代标志物的发展
trd。这项工作将有助于:1)MDD中的个性化药物通过建立治疗标记
反应,2)了解RTMS抗抑郁作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

暂无数据
数据更新时间:2024-06-01
RAYMOND Y CHO的其他基金
Prefrontal cortical engagement and clinical effects of non-invasive direct current stimulation for cognitive control impairments in schizophrenia
非侵入性直流电刺激对精神分裂症认知控制障碍的前额皮质参与和临床效果
- 批准号:96780819678081
- 财政年份:2017
- 资助金额:$ 20.48万$ 20.48万
- 项目类别:
Prefrontal Cortical Engagement and Clinical Effects of non-invasive Direct Current Stimulation for Cognitive Control Impairments in Schizophrenia
非侵入性直流电刺激对精神分裂症认知控制障碍的前额皮质参与和临床效果
- 批准号:91165649116564
- 财政年份:2016
- 资助金额:$ 20.48万$ 20.48万
- 项目类别:
Cross-frequency coupling and cognition in early psychosis
早期精神病的跨频耦合和认知
- 批准号:86817898681789
- 财政年份:2014
- 资助金额:$ 20.48万$ 20.48万
- 项目类别:
Computational and Neural Mechanisms of Context Processing in Schizophrenia
精神分裂症情境处理的计算和神经机制
- 批准号:82171788217178
- 财政年份:2008
- 资助金额:$ 20.48万$ 20.48万
- 项目类别:
Computational and Neural Mechanisms of Context Processing in Schizophrenia
精神分裂症情境处理的计算和神经机制
- 批准号:80181068018106
- 财政年份:2008
- 资助金额:$ 20.48万$ 20.48万
- 项目类别:
Computational and Neural Mechanisms of Context Processing in Schizophrenia
精神分裂症情境处理的计算和神经机制
- 批准号:76181607618160
- 财政年份:2008
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Computational and Neural Mechanisms of Context Processing in Schizophrenia
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- 批准号:73855087385508
- 财政年份:2008
- 资助金额:$ 20.48万$ 20.48万
- 项目类别:
Computational and Neural Mechanisms of Context Processing in Schizophrenia
精神分裂症情境处理的计算和神经机制
- 批准号:77553847755384
- 财政年份:2008
- 资助金额:$ 20.48万$ 20.48万
- 项目类别:
Generalized Signaling for Control in Schizophrenia
精神分裂症控制的广义信号传导
- 批准号:71774937177493
- 财政年份:2006
- 资助金额:$ 20.48万$ 20.48万
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Generalized Signaling for Control in Schizophrenia
精神分裂症控制的广义信号传导
- 批准号:70313187031318
- 财政年份:2006
- 资助金额:$ 20.48万$ 20.48万
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