Advancing and calibrating anisotropic diffusion MR imaging brain connectome with Taxon brain network diffusion phantoms

使用 Taxon 脑网络扩散模型推进和校准各向异性扩散 MR 成像脑连接组

• 批准号: 9893037
• 负责人: Anthony P Zuccolotto
• 金额: $ 62.15万
• 依托单位: PSYCHOLOGY SOFTWARE TOOLS, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9893037
• 关键词: 3D Print; Algorithms; Anatomy; Animals; Axon; Biophysics; Brain; Brain imaging; Caliber; Calibration; Clinical; Communities; Computer software; Corpus Callosum; Data; Data Set; Department of Defense; Diffuse; Diffusion; Diffusion Magnetic Resonance Imaging; Dimensions; Disease; Electron Microscope; Equipment; Eye; Fiber; Geometry; Goals; Government; Heating; Histology; Human; Image; Imaging Phantoms; Industrialization; Laboratories; Light Microscope; Liquid substance; MRI Scans; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methods; Modeling; Monitor; Nanotubes; Neurodegenerative Disorders; Optics; Oxygen; Pathology; Phase; Physiologic pulse; Polymers; Production; Publications; Publishing; Quality Control; Radiology Specialty; Reporting; Reproducibility; Research; Research Personnel; Route; Running; Sampling; Scanning; Scoring Method; Ships; Site; Speed; Spinal Cord; Structure; System; Taxon; Technology; Temperature; Testing; Textiles; Time; Time Series Analysis; Tissues; Tracer; Traumatic Brain Injury; Tube; United States National Institutes of Health; Variant; Vendor; Water; base; brain tract; clinically significant; connectome; cost; density; developmental disease; economic cost; human tissue; improved; instrument; microCT; millimeter; nanometer; nanoscale; network models; open data; pathology imaging; programs; quality assurance; success; tractography; tumor; white matter; 3D Print; Algorithms; Anatomy; Animals; Axon; Biophysics; Brain; Brain imaging; Caliber; Calibration; Clinical; Communities; Computer software; Corpus Callosum; Data; Data Set; Department of Defense; Diffuse; Diffusion; Diffusion Magnetic Resonance Imaging; Dimensions; Disease; Electron Microscope; Equipment; Eye; Fiber; Geometry; Goals; Government; Heating; Histology; Human; Image; Imaging Phantoms; Industrialization; Laboratories; Light Microscope; Liquid substance; MRI Scans; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methods; Modeling; Monitor; Nanotubes; Neurodegenerative Disorders; Optics; Oxygen; Pathology; Phase; Physiologic pulse; Polymers; Production; Publications; Publishing; Quality Control; Radiology Specialty; Reporting; Reproducibility; Research; Research Personnel; Route; Running; Sampling; Scanning; Scoring Method; Ships; Site; Speed; Spinal Cord; Structure; System; Taxon; Technology; Temperature; Testing; Textiles; Time; Time Series Analysis; Tissues; Tracer; Traumatic Brain Injury; Tube; United States National Institutes of Health; Variant; Vendor; Water; base; brain tract; clinically significant; connectome; cost; density; developmental disease; economic cost; human tissue; improved; instrument; microCT; millimeter; nanometer; nanoscale; network models; open data; pathology imaging; programs; quality assurance; success; tractography; tumor; white matter

There is a critical gap in the reliability of anisotropic diffusion magnetic resonance imaging (AdMRI). This gap can be filled by using a ground truth measurement capability that allows for the necessary parametric control of water filled geometries of tubes at the micron scale that can produce paths representative of the millions of axons across centimeters in brain tract trajectories. Diffusion Tensor Imaging (DTI) publications report clinically significant systematic error that confounds accurate quantitative assessments across instruments and time. Reference phantoms that provide exact error metrics will advance MRI biophysics science and clinical quantitative accuracy. Correction algorithms using reference data can reduce systematic measurement error, enabling accurate reproducible measurement and provide cross scanner norms for AdMRI pathology. This project will deliver the first viable AdMRI phantom “ground truth” using ‘Taxons™’ (textile axon shaped nanotubes), invented by this team, and apply advanced bi-component polymer nanoscale production methods to create structures matched to human tissue histology. In doing this we will deliver axon scale taxons at 800 nanometer diameter, with a packing density of one million taxons per mm2, matched to actual human corpus callosum axon measurements. In Phase I we proposed and delivered taxons with 12 micron inner diameter tubes with a packing density of 1241 per mm2 that could be filled with water and produce FA measurement in the human tissue range. We actually “over- delivered”, exceeding a packing density of 1,000,000 per mm2 covering the human axonal tissue range. We can now precisely parametrically control the diameters, packing density, restricted/hindered, and isotropic water fractions to test and improve leading compartmental models of diffusion. We created a fasciculus routing machine that can, at viable cost, create human scale fasciculus routes matched to human tissue, such as the optic system eye to LGN, of 20 million routed taxons. The 1 to 1 scale taxonal network phantoms quantify dMRI measurement accuracy for each taxon path with 100 micron path precision along the trajectory. We scanned the phase I phantoms at ten sites. We established in empirical studies that there is substantial systematic, cross instrument and measurement error (e.g., 5x the TBI effect size), that the error is stable, and can be corrected for (removed 94% of systematic error). Phase II of this project will: 1) provide the first AdMRI phantom for ground truth measurement to quantify dMRI biophysics, spatial homogeneity, and routing precision; 2) provide fully automated quantification of accuracy and repeatability of measurement; 3) assess AdMRI precision of 20+ sites, quantifying measurement error at 1.5, 3, 7, 9.4 and 14T field strength; and4) develop a set of routing phantoms (Eye>LGN> V1, spinal cord and cortical tracts). These phantoms and/or subcomponents will be measured with non-MRI methods (confocal & electron microscope) using NIST traceable measurements. Researchers and center directors involved in Phase I scanning and reviewing of the results were very positive, with 30+ sites offering free scanning time to use the phantom, and to utilize the resulting quality assurance reports. Radiology has had phantom based pivotal successes (i.e., CT Hounsfield phantoms in the 1990s). This project will deliver a quantitative AdMRI phantom, enabling MRI metrics to become accurate across vendors and time implementing quantitative quality assurance (QQA).

各向异性扩散磁共振成像的可靠性（ADMRI）存在临界差距。这个差距可以是 通过使用地面真相测量能力填补，该能力允许对水充满的必要参数控制 在微米尺度上的管子的几何形状，可以产生代表数百万轴轴承数百万轴分的路径 脑道轨迹。扩散张量成像（DTI）出版物报告了临床上明显的系统错误 混淆了跨工具和时间的准确定量评估。提供确切错误的参考幻影 指标将提高MRI生物物理学科学和临床定量准确性。使用参考数据的校正算法 可以减少系统的测量误差，实现准确的可重复测量并提供交叉扫描仪规范 对于Admri病理学。该项目将使用“ tackons™”（纺织品 轴突形纳米管），由该团队发明，并应用高级双组分聚合物纳米级生产方法 创建与人组织组织学匹配的结构。为此，我们将以800纳米的方式提供轴突秤分类单元 直径为每MM2的包装密度为100万个分类群，与实际的人体call体轴突匹配 测量。在第一阶段，我们提出并交付了带有12微米内径管的分类单元，其包装密度为 每MM2的1241可以充满水并在人体组织范围内产生FA测量。我们实际上“过度 - 交付”，超过覆盖人轴突组织范围的每mm2的包装密度。我们现在可以 精确地控制直径，堆积密度，受限/阻碍和各向同性水分的测试和 改善领先的扩散隔室模型。我们创建了一台筋膜路由机，可以以可行的成本创建 人类规模的筋膜路线与人体组织相匹配，例如2000万个路由分类单元的光学系统。 1到1比例的分类网络幻影量化了每种分类量路径的DMRI测量精度 沿轨迹的精度。我们在十个站点扫描了I期幻影。我们在经验研究中建立了 是实质性的系统，跨仪器和测量误差（例如，TBI效应大小为5倍），误差是稳定的，并且 可以纠正（删除系统错误的94％）。该项目的第二阶段将：1）提供第一个Admri幻影 为了量化DMRI生物物理学，空间均匀性和路由精确度的地面真相测量； 2）完全提供 自动量的准确性和测量重复性； 3）评估20多个站点的ADMRI精度，量化 1.5、3、7、9.4和14T场强的测量误差；和4）开发一组路由幻影（眼睛> lgn> v1，脊柱 绳索和皮质区）。这些幻像和/或子组件将通过非MRI方法（共焦＆ 电子显微镜）使用NIST可追溯测量值。参与I期扫描的研究人员和中心董事 对结果的审查非常积极，有30多个站点提供使用幻影的免费扫描时间，并使用 由此产生的质量保证报告。放射学取得了基于幻影的关键成功（即CT Hounsfield Phantoms 在1990年代）。该项目将提供定量的ADRI幻影，使MRI指标能够准确地跨越 供应商和实施定量质量保证（QQA）的时间。