Dissecting the assembly of vertebrate neurotransmitter release sites-Research Supplements to Promote Diversity in Health-Related Research

剖析脊椎动物神经递质释放位点的组装——促进健康相关研究多样性的研究补充

• 批准号: 9896449
• 负责人: Pascal Simon Kaeser
• 金额: $ 3.01万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-13 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9896449
• 关键词: Address; Admission activity; Affect; Brain; Brain Diseases; Cell membrane; Communication; Complement; Data; Experimental Designs; Florida; Goals; Health; Hispanics; Latino; Lead; Learning; Learning Skill; Mentors; Molecular; Neurons; Neurosciences; Neurotransmitters; Phase; Proteins; Research; Research Support; Research Training; Schools; Science; Site; Structure; Synapses; Techniques; Universities; Work; career; design; experience; experimental study; falls; insight; interest; matriculation; neurotransmitter release; operation; presynaptic; programs; protein complex; recruit

Abstract This is an application for an administrative diversity supplement to R01 MH113349, “Dissecting the assembly of vertebrate neurotransmitter release sites” to support the research training and experience of Christopher Minasi. Christopher is a recent graduate of Florida Atlantic University. Christopher is Hispanic/Latino, a group that is underrepresented in biomedical sciences. He has a B.S. in Neuroscience and is highly interested in pursuing a career as a neuroscientist. Currently, he is participating in a post-baccalaureate program at Harvard, preparatory to applying to graduate school for matriculation in the fall of 2020. Christopher's work will elucidate three scientific questions in three phases. In the first phase, Christopher will determine whether ELKS can be recruited to the presynaptic plasma membrane upon disruption of the active zone protein complex, and preliminary data support that this is possible. In the second phase, Christopher will assess the mechanisms through which ELKS is recruited to synapses. In the third phase, Christopher will answer what active zone proteins are recruited by ELKS, and he will determine the underlying mechanisms. This research plan is structured such that in the early phases, Christopher learns experimental designs and techniques, and the key concepts in the field. In the later phases, he will lead the project intellectually by formulating hypotheses, by designing experiments to address these hypotheses, and by reaching scientific conclusions. This research experience is accompanied by multiple levels of mentoring, a focused plan to learn skills in scientific presentation, and guidance in developing a career in the neurosciences. It is also complemented with classwork to learn key concepts in molecular neuroscience. Together, the research and training plans are aimed at preparing Christopher for an academic career in neuroscience, with the concrete goal of admission to a top neuroscience graduate program by 2020.

抽象的 这是 R01 MH113349 的行政多样性补充申请，“剖析 脊椎动物神经递质释放位点”，以支持克里斯托弗·米纳西的研究培训和经验。 克里斯托弗是佛罗里达大西洋大学的一名应届毕业生。克里斯托弗是西班牙裔/拉丁裔美国人。 他拥有神经科学学士学位，并且对攻读博士学位非常感兴趣。 目前，他正在哈佛大学攻读学士学位后课程，作为一名神经科学家。 申请2020年秋季研究生院入学。 克里斯托弗的工作将分三个阶段阐明三个科学问题。 确定 ELKS 是否可以在活性破坏后被招募到突触前质膜 区域蛋白复合物，初步数据支持这在第二阶段是可能的，克里斯托弗将。 评估 ELKS 被招募到突触的机制 在第三阶段，Christopher 将回答。 ELKS 会招募哪些活性区域蛋白，他将确定潜在的机制。 研究计划的结构使得在早期阶段，克里斯托弗学习实验设计和 在后期阶段，他将通过以下方式来智力地领导该项目。 提出假设，通过设计实验来解决这些假设，并通过科学达到 结论 这种研究经验伴随着多层次的指导和有针对性的学习计划。 科学演示的技能以及发展神经科学职业的指导。 辅以课堂作业来学习分子神经科学的关键概念。 研究和培训计划共同旨在为克里斯托弗的学术生涯做好准备 神经科学，具体目标是到 2020 年进入顶尖神经科学研究生项目。