A SAFE AND COMPACT NEONATE TO ADULT NEUROIMAGING MRI SYSTEM

安全紧凑的新生儿到成人神经成像 MRI 系统

基本信息

批准号：
9897423
负责人：
Ravi Srinivasan
金额：
$ 99.91万
依托单位：
ADVANCED IMAGING RESEARCH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-24 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9897423
关键词：
2 year old Adult Affect Air Anatomy Animals Brain Brain imaging Caring Child Childhood Clinical Clinical Trials Coiled Bodies Complex Congenital Disorders Custom Detection Development Diagnosis Diagnostic Diffusion Effectiveness Feedback Flare Functional Magnetic Resonance Imaging Goals Growth Head Heart Diseases Hospital Departments Hospitals Human Image Image Enhancement Imaging technology Individual Infant Infusion Pumps Injury Intervention Ionizing radiation Left Limb structure Lung diseases Magnetic Resonance Imaging Maps Measures Medical Mental Health Mental disorders Musculoskeletal Diseases Neonatal Neonatal Intensive Care Units Neurodegenerative Disorders Newborn Infant Organ Outcome Oxygen Patient Care Patients Performance Phase Physiologic Monitoring Population Power Sources RF coil Radiology Specialty Research Research Support Resolution Risk Safety Scanning Small Business Innovation Research Grant Stroke Structure System Technology Testing Time United States National Institutes of Health Ventilator animal imaging base cardiac intensive care unit connectome cost design high risk infant imaging system innovation neonate nervous system disorder neuroimaging pediatric patients preterm newborn prototype repaired success tool touchscreen trend whole body imaging

项目摘要

NIH SBIR PA-18-871 w/o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System The intriguing human brain is the most imaged end-organ non-invasively, without ionizing radiation using magnetic resonance imaging (MRI). High spatial resolution brain MRI is an established diagnostic tool to assess injury mechanisms affecting newborn growth and the adult human connectome. To predict neuro- developmental outcome necessary to validate effectiveness of therapy in infants and adults, mapping dynamic anatomical and functional connectivity in the human brain is essential. However, many unstable premature newborns are kept from stat MRI diagnosis because transport to adult MRIs located remotely in the radiology department is highly risky. Serial MRI necessary to validate effectiveness of therapy or clinical intervention requiring multiple transports between the neonatal intensive care unit (NICU) and MRI sections places additional burden on the NICU staff and the baby. In its current form adult MRI's with many unrelated and unsuitable features for kids are expensive, complex and impractical for routine clinical use. The overall goal of this SBIR project is to create a compact MRI system, by combining innovations in patient-centric care and salient imaging technology. This safe system can be installed for whole-body imaging of sick children in the neonatal, pediatric and cardiac intensive care units. The `low-intrinsic risk' design ideal for safe pediatric use will be widely accepted by the hospital staff. The compact MRI is concurrently designed for imaging the adult brain, and suitable for installation in any hospital department or on a truck. The human connectome project (HCP) uses diffusion and BOLD-based functional MRI to derive whole-brain structural and functional connectivity maps for individual subjects at 1.25-2mm resolution (2-8µL voxels). Our research imaging goals are to attain targets between 0.125µL and 0.5µL isotropic voxels with the 100mT/m strong gradients over the neonatal and adult brain in support of research in reasonable scan times. Enhanced image quality obtained with the strong gradients can help unravel brain development and repair associated with a variety of neurological, psychiatric, neurodegenerative and congenital disorders. Our technology alleviates cost and safety burdens imposed by large foot-print adult whole-body MRIs on the hospital and pediatric patients. Multiple uses of the custom, compact MRI system with its combined patient-centric care and radiology approach proposed is original. A successful project will shift the trend from radiology based scanners to clinical departments where stat diagnosis is possible for pediatric patients and adults. Success of this project will stimulate development of a mobile mental health and stroke detection MRI systems, ultra-compact MRIs for extremity and small animal imaging, and mid- to low-field off-grid MRI for world use. A safer compact MRI for 0-2 year olds and adult is needed and will dramatically increase the quality of clinical MRI and connectome research. This project will also support advanced diagnosis in patients with lung, cardiac and musculoskeletal disorders.

NIH SBIR PA-18-871 未进行临床试验安全紧凑的新生儿到成人神经影像 MRI 系统有趣的是，人类大脑是非侵入性成像最多的终末器官，无需使用电离辐射磁共振成像 (MRI) 高空间分辨率脑部 MRI 是一种成熟的诊断工具。评估影响新生儿生长和成人连接组的损伤机制。验证婴儿和成人治疗有效性所必需的发育结果，绘图动态的解剖学和功能连接在人脑中至关重要，然而，许多连接是不稳定的。早产儿无法获得 MRI 诊断，因为成人 MRI 的运输距离较远放射科的连续 MRI 是验证治疗有效性所必需的。需要在新生儿重症监护病房 (NICU) 和 MRI 之间多次转运的临床干预在目前的成人 MRI 中，许多切片给 NICU 工作人员和婴儿带来了额外的负担。与儿童无关和不适合的功能对于常规临床使用来说昂贵、复杂且不切实际。该 SBIR 项目的总体目标是通过结合以下方面的创新来创建紧凑的 MRI 系统：以患者为中心的护理和显着的成像技术可以安装用于全身。新生儿、儿科和心脏重症监护病房中患病儿童的成像“低内在风险”。适合儿科安全使用的设计将被医院工作人员广泛接受。同时设计用于成人大脑成像，适合安装在任何医院科室或在卡车上。人类连接组项目 (HCP) 使用扩散和基于 BOLD 的功能 MRI 来导出个体受试者 1.25-2mm 的全脑结构和功能连接图我们的研究成像目标是达到 0.125μL 至 0.5μL 之间的目标。新生儿和成人大脑上具有 100mT/m 强梯度的各向同性体素以支持研究在合理的扫描时间内通过强梯度获得增强的图像质量可以帮助解决问题。与各种神经、精神、神经退行性疾病相关的大脑发育和修复我们的技术减轻了大足迹成人造成的成本和安全负担。定制紧凑型 MRI 系统的多种用途，用于医院和儿科患者的全身 MRI。其提出的以患者为中心的护理和放射学方法相结合是一个成功的项目。将使趋势从基于放射学的扫描仪转向可以进行统计诊断的临床部门对于儿科患者和成人来说，该项目的成功将刺激移动心理的发展。健康和中风检测 MRI 系统、用于四肢和小动物成像的超紧凑型 MRI，以及需要一种适合 0-2 岁儿童和成人的更安全的紧凑型 MRI。将显着提高临床 MRI 和连接组研究的质量。肺、心脏和肌肉骨骼疾病患者的高级诊断。