Biobehavioral Studies of Cardiovascular Disease

心血管疾病的生物行为研究

基本信息

批准号：
9762159
负责人：
Peter J Gianaros
金额：
$ 222.89万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9762159
关键词：
Acute Administrative Coordination Adult Affect Affective Arteriogram Award Base of the Brain Behavior Behavior assessment Behavioral Behavioral Medicine Bioinformatics Biological Biological Markers Biometry Biophysics Blood Vessels Brain Brain imaging Cardiovascular Diseases Cardiovascular Models Cardiovascular Physiology Cardiovascular system Characteristics Clinical Cohort Studies Collection Communities Complex Computer software Data Data Collection Data Science Discipline Disease Disease susceptibility Ecological momentary assessment Emotions Environment Environmental Exposure Epidemiology Etiology Exercise Future Goals Health behavior Human Immune Incidence Individual Individual Differences Intervention Intervention Studies Investigation Laboratories Life Life Stress Link Machine Learning Measurement Measures Mediating Mediator of activation protein Medicine Methodology Methods Monitor Names Neurobiology Neurosciences Neurosecretory Systems Parents Participant Pathway interactions Patient Recruitments Peripheral Phenotype Physical activity Physiological Physiology Plant Roots Predisposition Process Property Psychology Psychoneuroimmunology Psychophysiology Psychosocial Stress Public Domains Research Research Personnel Resources Risk Risk Marker Sampling Services Software Tools Source Stress Structure Survey Methodology Testing Time Translational Research Vascular Diseases Visceral Woman behavior influence biobehavior biobehavioral measurement cardiometabolic risk cardiovascular disorder risk cohort crosslink data management data resource epidemiology study experience health assessment hemodynamics instrumentation inter-individual variation interpersonal conflict longitudinal analysis men middle age multimodality neural circuit neuroimaging neuroregulation next generation novel physical inactivity pre-clinical programs prospective protective effect psychologic relating to nervous system research clinical testing resilience response social statistics stem stressor synergism tool

项目摘要

ABSTRACT Biobehavioral Studies of Cardiovascular Disease (PO1-HL040962) This Program Project (P01) continuation application focuses on the human brain substrates of behavioral and socio-environmental influences on cardiovascular disease (CVD) risk in midlife adults. Proposed are 3 Projects that are conceptually cross-linked and supported by 3 Core Units. Collaborative investigators represent multiple disciplines, including psychology, neuroscience, biophysics, medicine, psychoneuroimmunology, epidemiology, machine learning, bioinformatics, and statistics. Project 1 aims to elucidate functional and structural brain phenotypes that predict the multiyear progression of preclinical vascular disease and dysfunction, with a focus on neural circuitries for visceral control that coordinate autonomic, neuroendocrine, hemodynamic, and immune physiology with stress- and emotion-related behavioral processes. Project 2 aims to establish whether functional characteristics of these visceral control circuits moderate the influences of stress-related environmental exposures on the progression of preclinical vascular disease and dysfunction, tracking individuals' behavior and cardiovascular physiology in daily life to test a novel neuro-diathesis model of CVD risk. Project 2 also tests for the first time whether daily life physical activity associates with daily life stress physiology through its effects neural circuits for visceral control. Project 3 aims extend those of the other Projects by elucidating the neural and peripheral processes linking physical activity with physiological and psychophysiological markers of CVD risk (including daily life affect and stress physiology) using an experimental intervention methodology. These P01 aims are unique in cardiovascular behavioral medicine, and they will be pursued in the context of multi-component data collection efforts that satisfy all project-specific aims. As a result, the P01 will create new opportunities for integrative and translational science on the human neurobiology of CVD risk that cuts across multiple methods and levels of analysis. Helping to advance its parent field, the P01 will generate and disseminate original and expansive public-domain resources and tools to the broader scientific and clinical communities through comprehensive data and software sharing and educational objectives. Enabling a precise focus on early CVD etiology, the study cohorts comprise nearly 900 midlife adults without clinically apparent CVD, and study methods will include novel combinations of neuroimaging, ecological momentary assessments of experienced environments, ambulatory hemodynamic monitoring, autonomic, neuroendocrine, immune, and vascular assessments, laboratory clinical evaluations, hetero-method health behavior assessments, and arterial imaging. The 3 Core Units of this P01 provide for synergy and inter-project coordination by administrative, data management and participant accrual services; measurement and instrumentation support; and direction in cutting-edge bio-statistical and data-intensive (machine learning) analyses. The present application thus represents a thematic continuation and next- generation extension of translational neurobiological research on CVD by this P01, which was initiated in 1988.

抽象的心血管疾病的生物行为研究 (PO1-HL040962) 该计划项目（P01）延续申请重点关注行为和行为的人脑基质社会环境对中年成年人心血管疾病（CVD）风险的影响。拟建3个项目它们在概念上是交叉链接的，并由 3 个核心单元支持。合作调查人员代表多个学科，包括心理学、神经科学、生物物理学、医学、心理神经免疫学、流行病学、机器学习、生物信息学和统计学。项目 1 旨在阐明功能和预测临床前血管疾病多年进展的结构性脑表型功能障碍，重点是协调自主神经、神经内分泌、内脏控制的神经回路，血流动力学和免疫生理学以及与压力和情绪相关的行为过程。项目2目标确定这些内脏控制电路的功能特征是否缓和了与压力相关的环境暴露对临床前血管疾病和功能障碍进展的影响，跟踪个人在日常生活中的行为和心血管生理学，以测试一种新型的神经素质模型 CVD 风险。项目2还首次测试了日常生活体力活动是否与日常生活相关通过影响内脏控制的神经回路来调节应激生理学。项目 3 的目标是扩展其他项目的目标通过阐明将身体活动与生理和心理联系起来的神经和外周过程的项目 CVD 风险的心理生理标志（包括日常生活影响和应激生理学）实验干预方法。这些 P01 目标在心血管行为医学中是独一无二的，并且将在满足所有特定项目要求的多组成部分数据收集工作的背景下开展这些工作目标。因此，P01 将为人类综合和转化科学创造新的机遇 CVD 风险的神经生物学，跨越多种方法和分析水平。帮助推进其作为母领域，P01 将生成并传播原创且广泛的公共领域资源和工具，以通过全面的数据和软件共享和更广泛的科学和临床社区教育目标。该研究队列由近 900 名研究人员组成，能够精确关注早期 CVD 病因学没有临床明显心血管疾病的中年成年人，研究方法将包括以下新的组合：神经影像、经历环境的生态瞬时评估、动态血流动力学监测、自主神经、神经内分泌、免疫和血管评估、实验室临床评估、异质方法健康行为评估和动脉成像。该 P01 的 3 个核心单元提供了通过行政、数据管理和参与者应计服务进行协同和项目间协调；测量和仪器支持；尖端生物统计和数据密集型领域的发展和方向（机器学习）分析。因此，本申请代表了主题的延续和下一个- P01 是 CVD 转化神经生物学研究的代际延伸，该研究始于 1988 年。