Neural Response to Social Reward: Relationships with Depression Over Adolescence

对社会奖励的神经反应：与青春期抑郁的关系

• 批准号: 8832189
• 负责人: Jennifer N Bress
• 金额: $ 3万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8832189
• 关键词: 14 year old; 15 year old; Accounting; Adolescence; Adolescent; Adult; Biological Markers; Brain; Child; Clinical assessments; Data; Development; Diagnosis; Economics; Electroencephalography; Equation; Event; Feedback; Female Adolescents; Functional Magnetic Resonance Imaging; Funding; Future; Generations; Hormonal; Intervention; Interview; Link; Measures; Mental Depression; Methods; Modeling; Outcome; Participant; Patient Self-Report; Process; Puberty; Questionnaires; Recording of previous events; Research; Rewards; Risk; Risk Factors; Risk Marker; Sampling; Severities; Signal Transduction; Social Development; Symptoms; System; Techniques; Theoretical model; Time; Training; Variant; Ventral Striatum; base; boys; child depression; depressive symptoms; early adolescence; girls; maternal depression; novel; offspring; peer; psychologic; public health relevance; relating to nervous system; response; reward processing; screening; single episode major depressive disorder; social; subthreshold depression; theories

DESCRIPTION (provided by applicant): Rates of depression increase drastically during puberty - particularly in girls - and depression during this developmental period is associated with a host of negative psychological, social, academic, and financial consequences. Puberty is therefore a critical time during which to identify neural biomarkers of current symptomatology and risk that may clarify the etiopathogenesis of depression. The proposed study, sponsored by Dr. Greg Hajcak Proudfit, aims to delineate subtypes of the neural response to rewards - which has previously been associated with both current depression and risk for future depression - in a sample of 8- to 14-year-old girls. This project will be added onto an ongoing R01-funded study (PI: Greg Hajcak Proudfit) in which a number of measures are collected: self-report and interview-based measures of depression and pubertal development in the participants; interview-based measures of maternal depression; hormonal measures; and ERPs relating to the processing of monetary rewards. The current study will add a task to assess the ERP response to social rewards. Using structural equation modeling, puberty and depression will be modeled as latent variables. Analyses will be conducted to relate the neural response to social rewards to measures of both puberty and current depression. The relationship between the neural response to social rewards and maternal history of depression - an established marker of risk for depression - will also be assessed, excluding child participants with lifetime depression in order to isolate the effects of risk. Additional analyses will explore the extent to which the neural response to social rewards explains unique variation in depression when accounting for the response to monetary rewards. The proposed research plan will provide training in methods of assessing pubertal development (interview-based, questionnaire-based, and hormonal); theoretical models, neural correlates, and clinical assessment of depression in children and adolescents; clinical assessment of depression in adults; advanced statistical techniques; and advanced methods of EEG processing. This research will contribute to an enhanced understanding of neural reward-processing mechanisms related to ongoing symptomatology and risk for depression, and the neural responses being studied may eventually be added to interventions or screening panels for depression in children and adolescents.

描述（由申请人提供）：青春期期间抑郁症的发病率急剧增加，尤其是女孩，而这个发育时期的抑郁症与许多负面的心理、社会、学业和经济后果有关。因此，青春期是识别当前症状和风险的神经生物标志物的关键时期，这可能有助于阐明抑郁症的发病机制。这项拟议的研究由 Greg Hajcak Proudfit 博士赞助，旨在以 8 至 14 岁的样本为样本，描述对奖励的神经反应的亚型——此前这种神经反应与当前的抑郁症和未来抑郁症的风险有关。女孩们。该项目将被添加到正在进行的 R01 资助的研究（PI：Greg Hajcak Proudfit）中，其中收集了许多测量值：参与者的抑郁症和青春期发育的自我报告和基于访谈的测量值；基于访谈的母亲抑郁症测量；荷尔蒙措施；与金钱奖励处理相关的 ERP。当前的研究将增加一项任务来评估 ERP 对社会奖励的反应。使用结构方程模型，青春期和抑郁症将被建模为潜在变量。将进行分析，将对社会奖励的神经反应与青春期和当前抑郁症的测量联系起来。还将评估对社会奖励的神经反应与母亲抑郁症史（抑郁症风险的既定标志）之间的关系，排除患有终生抑郁症的儿童参与者，以隔离风险的影响。其他分析将探讨在考虑对金钱奖励的反应时，对社会奖励的神经反应在多大程度上解释抑郁症的独特变化。拟议的研究计划将提供评估青春期发育方法的培训（基于访谈、基于问卷调查和激素）；儿童和青少年抑郁症的理论模型、神经相关性和临床评估；成人抑郁症的临床评估；先进的统计技术；以及脑电图处理的先进方法。这项研究将有助于加深对与持续症状和抑郁症风险相关的神经奖励处理机制的理解，并且正在研究的神经反应最终可能会被添加到儿童和青少年抑郁症的干预措施或筛查小组中。