An Integrated, Accurate, and Rapid Peanut Allergen Detector for Consumers

为消费者提供集成、准确、快速的花生过敏原检测仪

• 批准号: 9515756
• 负责人: Francisco Javier Dias Lourenco
• 金额: $ 100万
• 依托单位: NIMA LABS, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-02-01 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9515756
• 关键词: 4 year old; Accounting; Adult; Affect; Affinity; Allergens; Allergy to peanuts; Antibodies; Biological Assay; Bluetooth; Caregivers; Chemistry; Child; Communities; Complex; Consumption; Custom; Dairy Products; Data Analyses; Databases; Detection; Devices; Diet; Disease Notification; Eating; Ensure; Equipment; Evaluation; Fluorescence; Food; Food Hypersensitivity; Food Processing; Food Safety; Funding; Future; Generations; Gluten; Government; Guidelines; Health; Health Personnel; High Prevalence; Hypersensitivity; Immunoassay; Individual; Irritants; Label; Lateral; Lead; Life; Manufacturer Name; Medical Care Costs; National Institute of Allergy and Infectious Disease; Nuts; Pain; Parents; Patients; Pediatrics; Performance; Persons; Phase; Population; Preparation; Prevalence; Price; Process; Proteins; Public Health; Quality of life; Reporting; Research; Resources; Restaurants; Safety; Sampling; Small Business Innovation Research Grant; Technology; Test Result; Testing; Time; Trees; United States; United States National Institutes of Health; Variant; base; cloud based; community living; cost; data exchange; data sharing; design; detector; egg; food allergen; handheld equipment; improved; mobile application; operation; portability; programs; prototype; sensor; soy; technological innovation; user-friendly

Pain Point: This Small Business Innovation Research Phase II project proposes to develop an unprecedented, all-in-one handheld device that integrates food processing, assay chemistry and data interpretation, thereby allowing consumers to easily test their food for peanut and, in the future, other food allergens. Food allergies are a growing food safety and public health concern in the United States (Gupta, R. JAMA Pediatrics, 2013; Liu, AH. J Allergy Clin Immunol, 2010), affecting 6–8% of the children under 4 and 3.7% of adults (Report of the NIH Expert Panel on Food Allergy Research, 2006). Peanut allergy is the most common cause of food allergy- related fatalities in the US (Bock, S.A. J Allergy Clin Immunol, 2007). Among children, peanut is the most prevalent dietary allergy, accounting for 25% of all food allergies. A strict and lifelong peanut-free diet is the only current treatment for these patients, but it can be difficult to adhere to because of (a) cross-contamination during food manufacturing and preparation processes and (b) inadequate labeling and testing mechanisms (Remington, B.C. Food Chem Toxicol, 2013). Traditional peanut tests are (1) complicated – most kits require 7+ steps and certain steps involve equipment that is not readily available to the user, such as a scale or grinding device; (2) expensive – costing more than $14 per test; and (3) time consuming – taking longer than 18 min per test. Fundamentally, there does not exist a consumer-oriented product that peanut-sensitive individuals can use to proactively ensure the safety of their food. Technological Innovation: Nima is building the first and only rapid and user-friendly solution that enables consumers to test their food for dietary allergens. The all-in-one, handheld device, NimaTM, internally grinds the food, extracts allergen proteins (specifically peanut protein under this proposal) with Nima’s proprietary extraction solution, performs the immunoassay and interprets the result, all within 3 minutes. Performing all of these operations internally significantly simplifies the test, minimizes opportunities for user error and variation and builds confidence in the test result. Further, users will have the option to automatically upload test results via Bluetooth to a mobile app that Nima is building. Results will be collected by both consumers and the Nima team and automatically entered into a database. Nima aims to build the largest living allergen (and gluten) test result database in the US, which will serve as a resource to the community living with food allergies, so that consumers can make smarter decisions about where and what to eat. Broader Impacts of the Technology are to provide food sensitive individuals, their parents or other caregivers, health care providers and food manufacturers with an easy means of testing foods, ensuring food safety and improving health. While Nima’s first product (now on the market) focused on gluten detection and the second will focus on peanut detection, this technology platform is expected to expand to the detection of other common food allergens or irritants, including tree nuts, dairy products, eggs and soy, among others.

痛点：这项小型企业创新研究阶段II阶段项目提案，以开发前所未有的， 整合食品加工，化学和数据解释的多合一手持设备，从而 允许消费者轻松地测试他们的花生食物，并在将来其他食物过敏原测试。食物过敏 在美国越来越多的食品安全和公共卫生问题（Gupta，R。JamaPediatrics，2013； Liu， 啊。 J Allergy Clin Immunol，2010年），影响4％和3.7％的成年人的6-8％ NIH食品过敏研究专家小组，2006年）。花生过敏是食物过敏的最常见原因 - 美国相关死亡（Bock，S.A。J Allergy Clin Immunol，2007年）。在儿童中，花生是最大的。 普遍的饮食过敏，占所有食物过敏的25％。严格而终生的无花生饮食是 仅针对这些患者的当前治疗 在食品制造和制备过程中以及（b）标签和测试机制不足 （卑诗省雷明顿，食品毒素，2013年）。传统的钢琴测试很复杂 - 大多数套件需要 7个以上的步骤和某些步骤涉及用户不容易获得的设备，例如秤或打磨 设备; （2）昂贵 - 每次测试的成本超过14美元； （3）耗时 - 每次花费超过18分钟 测试。从根本上讲，没有对花生敏感的人可以使用的面向消费者的产品 用于主动确保食物的安全。 技术创新：NIMA正在建立第一个也是唯一的快速且用户友好的解决方案 消费者测试食物的饮食过敏原。多合一的手持设备，nimatm，内部磨碎 食物，提取过敏原蛋白（特别是该提案下的花生蛋白）与Nima的专有 提取解决方案，执行免疫测定并解释结果，全部在3分钟内。执行全部 这些操作在内部大大简化了测试，最大程度地减少了用户错误的机会和 变化并建立对测试结果的信心。此外，用户将可以选择自动上传 通过蓝牙测试结果NIMA正在构建的移动应用程序。结果将由两位消费者收集 NIMA团队并自动进入数据库。 NIMA旨在建造最大的生物过敏原 （和面筋）在美国的测试结果数据库，该数据库将成为享受食物的社区的资源 过敏，以便消费者可以就饮食地点和饮食做出更明智的决定。 该技术的更广泛的影响是为食品敏感的人，他们的父母或其他 护理人员，卫生保健提供者和食品制造商，可轻松测试食物，确保食物 安全和改善健康。尼玛（Nima）的第一个产品（现在在市场上）着重于面筋检测和 第二个将重点放在花生检测上，预计该技术平台将扩展到检测到 其他常见的食物过敏原或刺激性，包括树坚果，乳制品，鸡蛋和大豆等。