Brain and Adipose Contributors to Food Seeking in Youth with Adrenal Hyperplasia

大脑和脂肪对患有肾上腺增生的青少年寻求食物有贡献

基本信息

批准号：
9475240
负责人：
Mimi Susan Kim
金额：
$ 17.09万
依托单位：
CHILDREN'S HOSPITAL OF LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-18 至 2020-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9475240
关键词：
Abdomen Adipose tissue Affect Age Amygdaloid structure Animal Experimentation Animal Model Area Attention Award Behavior Behavioral Biology Body Composition Body fat Brain Brain imaging Brain region California Calories Caring Child Childhood Clinical Research Congenital adrenal hyperplasia Cues Data Decision Making Desire for food Discipline Dual-Energy X-Ray Absorptiometry Endocrine Endocrine System Diseases Endocrinology Epidemic Exhibits Fasting Fatty acid glycerol esters Feedback Food Functional Magnetic Resonance Imaging Funding Genetic Goals Growth and Development function Health Health Care Costs Health Food Healthcare Systems Hormones Human Hydrocortisone Hyperphagia Hypothalamic structure Image Imagery Impairment Institutes Intervention Investigation Lead Learning Lesion Los Angeles Magnetic Resonance Imaging Measures Medical Mentors Mentorship Metabolic Metabolic hormone Metabolism Methodology Motivation Neonatal Screening Neuroanatomy Neurobiology Neurosecretory Systems Newborn Infant Nucleus Accumbens Obesity Palate Pathway interactions Patient Self-Report Pediatric Hospitals Peripheral Positioning Attribute Prefrontal Cortex Prevalence Prevention Process Psychology Research Research Personnel Rewards Risk Rodent Satiation Science Scientist Self-control as a personality trait Statistical Methods Structure Study models System Taste Perception Technical Expertise Technology Testing Testosterone Training United States United States National Institutes of Health Weight Gain Youth abdominal fat adipokines adrenal hyperplasia base cohort comparison group craving design emotional stimulus experience feeding human model medical schools metabolic abnormality assessment motivated behavior multidisciplinary neurobehavior neurobehavioral neuroimaging novel obesity in children pediatric department prenatal public health relevance response sex therapy development

项目摘要

DESCRIPTION (provided by applicant): The goal of the proposed mentored research is to investigate the neurobiology of food-seeking behaviors in children, and to provide Dr. Mimi Kim the in-depth training and mentorship to become an independent investigator in childhood obesity and metabolism. This proposal targets children with congenital adrenal hyperplasia (CAH) as a natural human model for the study of brain and adipose contributors to obesity. Her long-term goal is to become a clinical research leader in childhood obesity with an emphasis on prevention and treatment. Dr. Kim joined the Department of Pediatrics at the Keck School of Medicine of USC and the Division of Endocrinology at Children's Hospital Los Angeles in 2009 under the mentorship of Dr. Mitchell Geffner, an expert in childhood endocrine disorders, including CAH. Children with CAH have abnormalities in neuroendocrine function and brain structures related to self-control and reward, and are more likely to be obese than children without CAH. Specifically, Dr. Kim will measure food-seeking behavior, body fat, metabolic hormones, and brain activity in regions involved in reward (e.g., amygdala and nucleus accumbens) and inhibitory control (pre-frontal cortex) in children with CAH and in an unaffected comparison group (Non-CAH). Prior research has shown that children with CAH have abnormal amygdala volumes and function, and decreased inhibitory control during motivated behavior. Food-seeking behaviors have not been studied in children with CAH; however, there is a wealth of animal research on impaired amygdala function and food- seeking behavior. Dr. Kim hypothesizes that 1) a small amygdala, as observed in CAH, is associated with obesity, and that 2) children with CAH exhibit less inhibitory control and greater brain reward response to highly palatable food cues. The specific aims are to: 1) determine whether amygdala size is inversely associated with adiposity and body composition in CAH youth vs. Non-CAH youth; 2) determine whether activation of inhibitory control regions is decreased and activation of reward regions is increased in response to food cues in CAH youth; and 3) evaluate decision-making with regard to food choices in CAH and Non-CAH groups from Aim 1. Through mentored training and didactic learning, Dr. Kim will develop specific expertise in: 1) structural magnetic resonance imaging (MRI) of the brain and abdomen, 2) functional MRI of the brain and administering a food cues-based task in the scanner, 3) a neurobehavioral task involving food decision- making, and 4) statistical methods useful for conducting human research. Guided by highly expert and collaborative mentors from multiple disciplines, Dr. Kim will acquire technical skills and an understanding of how to effectively conduct and lead team science. Her project will establish a human model for the study of the amygdala, appetite, food-seeking behaviors, and obesity in children using sophisticated MRI measures. Understanding the neurobiology of food-seeking behaviors in children could inform much-needed development of interventions for obese children with and without CAH.

描述（由申请人提供）：拟议的指导研究的目标是调查儿童觅食行为的神经生物学，并为 Mimi Kim 博士提供深入的培训和指导，使其成为儿童肥胖和肥胖问题的独立研究者。该提案针对先天性肾上腺增生症（CAH）儿童作为研究大脑和脂肪导致肥胖的自然人体模型，她的长期目标是成为儿童肥胖症的临床研究领导者。 Kim 博士于 2009 年在儿童内分泌疾病专家 Mitchell Geffner 博士的指导下加入南加州大学凯克医学院儿科和洛杉矶儿童医院内分泌科。患有CAH的儿童在神经内分泌功能和与自我控制和奖赏相关的大脑结构方面存在异常，并且比没有CAH的儿童更容易肥胖。具体来说，金博士将进行测量。 CAH 儿童和未受影响的对照组（非 CAH）中涉及奖赏（例如杏仁核和伏核）和抑制控制（前额皮质）的食物寻求行为、身体脂肪、代谢激素和大脑活动之前的研究表明，患有 CAH 的儿童杏仁核体积和功能异常，并且在主动行为期间的抑制控制尚未得到研究。对杏仁核功能受损和觅食行为进行了大量的动物研究，Kim 博士注意到：1）CAH 中观察到的杏仁核过小与肥胖有关，2）患有 CAH 的儿童表现出较少的抑制控制能力。具体目标是：1）确定 CAH 青少年与非 CAH 青少年的杏仁核大小是否与肥胖和身体成分呈负相关； 2) 确定针对 CAH 青少年的食物线索，抑制控制区的激活是否减少，奖励区的激活是否增加；3) 评估目标 1 中 CAH 和非 CAH 群体的食物选择决策。通过指导培训和教学学习，Kim 博士将发展以下方面的具体专业知识：1）大脑和腹部的结构磁共振成像（MRI），2）大脑的功能性 MRI 并在扫描仪中管理基于食物线索的任务， 3）神经行为任务食品决策，以及4）涉及进行人类研究的统计方法在来自多个学科的高度专家和协作导师的指导下，金博士将获得技术技能并了解如何有效地进行和领导。她的项目将建立一个人体模型，利用复杂的核磁共振测量来研究儿童的杏仁核、食欲、觅食行为和肥胖，了解儿童觅食行为的神经生物学可以为儿童急需的发育提供信息。对患有和不患有 CAH 的肥胖儿童进行干预。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Altered Emotion Perception Linked to Structural Brain Differences in Youth With Congenital Adrenal Hyperplasia.

先天性肾上腺增生症青少年的情绪感知改变与大脑结构差异有关。

DOI：
10.1210/clinem/dgad158
发表时间：
2023
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
0
作者：
Omary,Adam;Khalifeh,Noor;Cotter,DevynL;Kim,MimiS;Choudhury,Farzana;Ahmadi,Hedyeh;Geffner,MitchellE;Herting,MeganM
通讯作者：
Herting,MeganM

Assessment of Facial Morphologic Features in Patients With Congenital Adrenal Hyperplasia Using Deep Learning.

DOI：
10.1001/jamanetworkopen.2020.22199
发表时间：
2020-11-02
期刊：
JAMA network open
影响因子：
13.8
作者：
AbdAlmageed W;Mirzaalian H;Guo X;Randolph LM;Tanawattanacharoen VK;Geffner ME;Ross HM;Kim MS
通讯作者：
Kim MS

No evidence for a difference in 2D:4D ratio between youth with elevated prenatal androgen exposure due to congenital adrenal hyperplasia and controls.

DOI：
10.1016/j.yhbeh.2020.104908
发表时间：
2021-03
期刊：
Hormones and behavior
影响因子：
3.5
作者：
Nave G;Koppin CM;Manfredi D;Richards G;Watson SJ;Geffner ME;Yong JE;Kim R;Ross HM;Serrano-Gonzalez M;Kim MS
通讯作者：
Kim MS

Electrolyte abnormalities and stress dosing predict illness-related hospitalizations among infants and toddlers with congenital adrenal hyperplasia.

电解质异常和应激剂量可预测患有先天性肾上腺增生的婴儿和幼儿因疾病相关的住院治疗。

DOI：
10.1111/cen.14876
发表时间：
2023
期刊：
Clinical endocrinology
影响因子：
3.2
作者：
Tseng,Teresa;Seagroves,Amy;Tanawattanacharoen,VeerayaK;Liang,MarkC;Koppin,ChristinaM;Keenan,Madison;Davidowitz,Elana;Nguyen,Eugene;Chand,Sanjay;Geffner,MitchellE;Chang,ToddP;Kim,MimiS
通讯作者：
Kim,MimiS

Differences in Hyperandrogenism Related to Early Detection of Non-Classical Congenital Adrenal Hyperplasia on Second Newborn Screen.