Training Program in Lung Biology and Translational Medicine

肺生物学和转化医学培训计划

• 批准号: 9756439
• 负责人: AMIT GAGGAR
• 金额: $ 32.16万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-20 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9756439
• 关键词: Biology; Lung; Training Programs; translational medicine

 DESCRIPTION (provided by applicant): The Training Program in Lung Biology and Translational Medicine at the University of Alabama at Birmingham (UAB) provides multidisciplinary training in a stimulating and collaborative environment that nurtures the development of highly competent and innovative biomedical research scientists. This Program, initiated in 2010 to train M.D. or Ph.D. postdoctoral fellows in lung-related research, is currentl in its 4th year with a current allocation of 5 trainees (2-3-4-5-5, for years 1-5). In the first 3. years of the Program, we have graduated three trainees, all in academic research positions, two of the three are in full-time academic research faculty positions and the third receiving advanced post-doctoral training at another institution; with five additional trainees currently in the Progrm. The multidisciplinary and translational approach to the proposed training has been highly successful, and is highlighted by a diverse and interactive group of thirty faculty mentors who hold primary appointments in eight UAB Departments (4 - basic science; 4 - clinical). This includes the successful transition of "junior mentors" to the regular faculty mentoring pool. The faculty mentors are grouped into three thematic areas based on scientific expertise: (1) immunology-microbiology; (2) cell biology-tissue repair; (3) translational sciences. Translational research in statistical genetics, computational biology, biomarker discovery, and drug discovery/development and clinical trials (group 3) will facilitate the clinical translation of basc science research (groups 1 and 2). Based on the existing expertise and ongoing research efforts at UAB, training will focus on the manifestations, diagnosis, risk/prognostic stratificatio, mechanisms, prevention, and treatment of lung diseases, primarily acute lung injury (ALI), cystic fibrosis (CF), asthma, chronic obstructive lung diseases (COPD), and interstitial lung diseases (ILD). Training programs will be highly individualized and tailored to maximize success of each trainee with the creation of individual development plans (IDPs). In addition to the research projects that will be conducted in the mentor's laboratory, training will encompass a highly structured didactic program that includes weekly teaching conferences in the Division of Pulmonary, Allergy and Critical Care Medicine, a "survival skills" curriculum (in collaboration with the UAB Office of Postdoctoral Education) and a Research Core Curriculum that includes emerging themes such as cellular plasticity, drug discovery/development, "big data", computational biology, and personalized medicine. Formal instruction will include the responsible and ethical conduct of research. A priority in the next phase of this Program is the recruitment/retention of underrepresented minorities, and maintaining the current high-rate of trainee retention in academic biomedical research careers.

 描述（由申请人提供）：阿拉巴马大学伯明翰分校 (UAB) 的肺生物学和转化医学培训项目在刺激和协作的环境中提供多学科培训，培养高素质和创新型生物医学研究科学家。于 2010 年启动，旨在培训肺相关研究的医学博士或博士后研究员，目前已进入第四年，目前分配了 5 名学员（2-3-4-5-5，针对第 1-5 年）。在该计划的前 3 年，我们已毕业三名学员，全部担任学术研究职位，其中两人担任全职学术职务。教师研究职位和第三个在另一家机构接受博士后培训的高级人员；目前该计划还有另外五名学员。拟议的培训的多学科和转化方法非常成功，并由三十名多元化和互动的小组强调。担任主要任命的教师导师有八个UAB 系（4 - 基础科学；4 - 临床）这包括“初级导师”成功过渡到常规教师队伍。导师根据科学专业知识分为三个主题领域：（1）免疫学-微生物学。 (2) 细胞生物学-组织修复；(3) 统计遗传学、计算生物学、生物标志物发现、药物发现/开发和临床试验的转化研究（第 3 组）将促进临床转化。基础科学研究（第 1 组和第 2 组）。根据 UAB 现有的专业知识和正在进行的研究工作，培训将重点关注肺部疾病（主要是急性肺损伤）的表现、诊断、风险/预后分层、机制、预防和治疗。 (ALI)、囊性纤维化 (CF)、哮喘、慢性阻塞性肺病 (COPD) 和间质性肺疾病 (ILD) 培训计划将高度个性化和量身定制，以最大限度地提高每位学员的成功率。除了将在导师实验室进行的研究项目外，培训还将包括高度结构化的教学计划，其中包括肺科、过敏和重症监护医学科的每周教学会议。生存技能”课程（与 UAB 博士后教育办公室合作）和研究核心课程，其中包括细胞可塑性、药物发现/开发、“大数据”、计算生物学和个性化医疗等新兴主题。正式教学将该计划下一阶段的优先事项是招募/保留代表性不足的少数群体，并保持学术生物医学研究职业中目前的高实习生保留率。