Training in Pediatric Cancer Survivorship Outcomes and Interventions

儿科癌症生存结果和干预措施培训

• 批准号: 9886207
• 负责人: Kevin R Krull
• 金额: $ 16.66万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9886207
• 关键词: Cancer Survivorship; Intervention; Malignant Childhood Neoplasm; Outcome; Training; Cancer Survivorship; Intervention; Malignant Childhood Neoplasm; Outcome; Training

PROJECT SUMMARY/ABSTRACT Remarkable gains have been made in the treatment of pediatric cancers over the past 50 years resulting in a growing population of long-term survivors of childhood cancer that is anticipated to exceed 500,000 by 2020. Many long-term survivors experience chronic health conditions and poor health behaviors, which significantly contributes to medical burden and impacts functional outcomes and quality of life. Research on long-term survivors of pediatric cancer is continually informing the design of new treatment approaches for newly diagnosed patients, with the objective of minimizing long-term therapy-related morbidity and mortality. As the vast majority of children diagnosed with cancer will become long-term survivors and will be at risk for experiencing multiple complications following treatment, continued research is needed to enhance health and functional outcomes. Future research efforts will require well-trained independent investigators from the fields of oncology, epidemiology, biostatistics, behavioral and social sciences, cancer biology and genetics, health services, and other allied health disciplines. While some T32-funded cancer training programs offer training opportunities in cancer survivorship, few academic institutions possess the resources and large multidisciplinary team that St. Jude does to provide in-depth post-doctoral research training focusing on pediatric cancer populations. Currently, there are no NIH-funded training programs with a primary focus on pediatric cancer survivorship. The purpose of the proposed training program is to develop the next generation of scientific leaders with the interdisciplinary skills and knowledge that is necessary to become world-class competitive scientists in the area of pediatric cancer survivorship. Our new program will maintain three postdoctoral fellow positions the first three years and four positions beginning in year 4. The key elements to the program includes: a Scholarship Oversight Team comprised of a primary and secondary mentors and a clinical collaborator; a Management Committee to review program progress; an Advisory Committee; clinical and research training relating to cancer survivorship and pediatric oncology; a formal but flexible MPH curriculum in epidemiology, biostatistics or health systems policy; training in scientific writing, grant preparation and grant review; a requirement that trainees submit a research grant by the end of their second year in the program; and a detailed evaluation that will track the ongoing progress of the trainees and their subsequent careers. The innovation and uniqueness of the program includes its comprehensive focus on pediatric cancer survivorship across the lifespan of the survivor.

项目摘要/摘要 在过去的50年中，在儿科癌症的治疗中取得了显着收益，导致 到2020年，越来越多的儿童癌症长期幸存者人口将超过500,000。 许多长期幸存者经历了慢性健康状况和健康行为不佳，这显着 有助于医疗负担，并影响功能成果和生活质量。长期研究 小儿癌的幸存者不断地为新的治疗方法设计新的治疗方法 诊断为患者，目的是最大程度地减少与治疗相关的发病率和死亡率。作为 绝大多数被诊断出患有癌症的儿童将成为长期幸存者，并有可能 治疗后经历多种并发症，需要继续研究以增强健康和 功能结果。未来的研究工作将需要训练有素的独立研究人员 肿瘤学，流行病学，生物统计学，行为和社会科学，癌症生物学和遗传学，健康 服务和其他联盟健康学科。虽然一些T32资助的癌症培训计划提供培训 癌症生存的机会，很少有学术机构拥有资源​​和大量 圣裘德（St. Jude 小儿癌种群。目前，没有NIH资助的培训计划，主要关注 小儿癌的生存。拟议的培训计划的目的是开发下一代 具有跨学科技能和知识的科学领袖，成为世界一流的必要 小儿癌症生存领域的竞争科学家。我们的新计划将维持三个 博士后同位职位前三年，从第4年开始四个职位。 该计划包括：由主要和次级导师组成的奖学金监督团队以及 临床合作者；管理委员会审查计划进度的委员会；咨询委员会；临床 以及与癌症生存和小儿肿瘤学有关的研究培训；正式但灵活的MPH 流行病学，生物统计学或卫生系统政策的课程；科学写作培训，授予准备 和授予审查；要求受训者在第二年结束之前提交研究赠款的要求 程序;以及详细的评估，将跟踪受训者的持续进展及其后续 职业。该计划的创新和独特性包括其对小儿癌的全面关注 幸存者的生存期。