Ethnicity and Nativity in Cancer - Latino & Asian Enclaves: The ENCLAVE Study

癌症中的种族和出生地 - 拉丁裔

• 批准号: 9885937
• 负责人: Sandi Leigh Pruitt
• 金额: $ 62.92万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9885937
• 关键词: Address; Adopted; American; Asian Americans; Asians; Attention; Automobile Driving; Breast; Businesses; California; Cancer Center; Cancer Control; Cause of Death; Cervix Uteri; Chinese People; Collaborations; Colorectal; Colorectal Cancer; Communities; Community Outreach; Country; Cuban; Data; Development; Diagnosis; Early Diagnosis; Ensure; Environment; Ethnic Origin; Ethnic group; Filipino; Florida; Funding; Future; Geography; Health; Health Promotion; Healthcare; Heterogeneity; Immigrant; Immigration; Incidence; Individual; Infrastructure; Intervention; Japanese Population; Joints; Koreans; Latina; Latino; Leadership; Linguistics; Link; Literature; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Measures; Methodology; Methods; Mexican; NCI-Designated Cancer Center; Neighborhoods; New Jersey; New York; Outcome; Patients; Pattern; Population; Population Growth; Procedures; Puerto Rican; Race; Research Personnel; Resources; Role; Science; South Asian; Stage at Diagnosis; Subgroup; Texas; Time; cancer health disparity; cancer prevention; cancer site; cancer type; data registry; design; disadvantaged population; disparity reduction; ethnic minority population; evidence base; experience; health disparity; improved; improved outcome; indexing; malignant breast neoplasm; mortality; multilevel analysis; neighborhood disadvantage; neoplasm registry; novel; population based; programs; racial and ethnic; residence; resilience; response; social; social capital; socioeconomic disadvantage; stressor; surveillance data

Project Summary/Abstract Cancer is the leading cause of death for Latinos and Asian Americans, who are among the fastest growing populations in the U.S. A large proportion of Latinos and Asian Americans live in ethnic enclaves—distinct neighborhoods with high concentrations of individuals of the same ethnic origin (“co-ethnic residents”) that are also characterized by recent immigration and linguistic isolation. The existing literature is mixed, with some studies showing that ethnic enclave residence (vs. non-enclave residence) and foreign- (vs. U.S.-) birthplace are associated with both better and/or worse outcomes across the cancer continuum. In this study, we will pool cancer registry data across five states (CA, FL, NJ, NY, TX) comprising the majority of Latinos and Asian Americans in the U.S. and link these data to contextual data characterizing the social, built and healthcare environments. We will determine whether and how ethnic enclave residence and foreign-birthplace are associated with three cancer outcomes (incidence, stage at diagnosis, survival) experienced by nine of the largest Latino and Asian ethnic groups (Cuban, Mexican, Puerto Rican, Chinese, Filipino, Japanese, Korean, South Asian, Vietnamese) diagnosed with three cancer types (breast, cervical, and colorectal cancers). Specifically, we aim to define and characterize ethnic enclaves, and examine cancer incidence by enclave residence (Aim 1) and determine independent and joint associations of ethnic enclave residence and nativity (foreign vs. US birthplace) on stage at diagnosis (Aim 2) as well as on mortality (Aim 3). With over 200,000 Latino and Asian American breast, colorectal, and cervical cancer cases, we will use multilevel models to understand the impact of ethnic enclaves on cancer outcomes for these understudied populations. In doing so, our study will accelerate discovery about the intersections between neighborhoods, ethnicity, nativity, and cancer and will improve data and methods used by central cancer registries across the U.S. Findings have potential to inform development of multilevel interventions to leverage enclave attributes that promote health and to address any barriers to reduce disparities and improve outcomes for our fastest growing ethnic minority and immigrant communities. We will disseminate our enclave measure and imputation procedures for missing data to the North American Association of Central Cancer Registries (NAACCR). In doing so, our methods will improve completeness of cancer registry data for surveillance of the growing Latino and Asian American populations. Our dissemination plan with collaboration from NAACCR leadership as well as the Offices of Community Outreach and Engagement at NCI Designated Cancer Centers in five states will ensure 1) methods are readily adopted by cancer registries and health disparities researchers across the nation; and 2) findings inform community-engaged efforts to address multilevel cancer disparities among Latino and Asian populations.

项目摘要/摘要 癌症是拉丁裔和亚裔美国人的主要死亡原因，他们是增长最快的人之一 美国的人口大量的拉丁美洲人和美国人居住在种族飞地中 - 独特 具有相同种族的浓度的社区（“共同族裔居民”） 也以最近的移民和语言隔离为特征。 研究表明，民族飞地居住（vs.非安克拉夫住所）和外国（与美国）出生地 在这项研究中，与癌症连续性的更好和/或更糟的结果相关 包括大部分拉丁裔亚洲人 美国的美国人，并将这些数据链接到表征社会，建筑和医疗保健的上下文数据 环境。 与三种癌症结局（发病率，诊断阶段，生存期）相关 最大的拉丁裔和亚洲族裔（古巴，墨西哥，波多黎各，中国，菲律宾，菲律宾，日语，韩国人， 南亚，越南语）被诊断出患有三种癌症类型（乳腺癌，宫颈和结直肠癌）。 具体来说，我们旨在定义和表征民族飞地，并通过飞地检查取消 居住（AIM 1）并确定族裔居民和耶稣降生的独立和共同关联 （外国与美国的出生地）在诊断（AIM 2）和死亡率上（AIM 3） 拉丁裔和亚裔美国人的乳房，结直肠癌和宫颈癌，我们将使用多级模型来 了解族裔飞地对这些研究的人群的影响。 我们的研究将对邻居引擎盖，种族，本地和和 癌症，并将改善美国中央癌症注册机构使用的数据和方法 有可能告知多项式干预措施的开发以利用促进健康的飞地属性 并解决任何障碍，以减少分类并改善成长最快的少数民族的成果 和移民社区。 北美中央癌症协会（NAACCR）的数据。 提高癌症注册表数据的完整性，以监视不断增长的拉丁裔和亚洲亚洲人 人口。 在NCI指定的五个州指定癌症中心的社区外展和参与将确保1） 方法很容易被全国的癌症登记和健康分类研究人员采用； 调查结果为社区参与的努力解决了解决拉丁裔和亚洲的多级癌症差异的努力 人群。