Oral Corticosteroid Use During Pregnancy and Risk for Preterm Birth

怀孕期间口服皮质类固醇的使用和早产风险

基本信息

批准号：
9754218
负责人：
Kristin Palmsten
金额：
$ 23.09万
依托单位：
HEALTHPARTNERS INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9754218
关键词：
37 weeks gestation Accounting Address Adrenal Cortex Hormones Alternative Therapies Applications Grants Area Asthma Attenuated Autoimmune Diseases Award Biostatistical Methods Birth California Childhood Clinical Pharmacology Complex Data Data Set Data Sources Disease-Modifying Second-Line Drugs Documentation Dose Education Environment Epidemiology Faculty Foundations Funding Goals Grant Health Health Personnel Health Professional Health Services Histologic Human Immunosuppression Inhalation Instruction K-Series Research Career Programs Knowledge Literature Measures Mediation Medicaid Medical Records Mentored Clinical Scientist Development Award (K08)Mentors Methodological Studies Methodology Modeling Modification Mothers Oral Outcome Pathology Pathway interactions Perinatal Pharmaceutical Preparations Pharmacists Pharmacology Phase Physicians Placenta Positioning Attribute Practice based research Pregnancy Pregnant Women Premature Birth Prospective cohort Proxy Public Health Publishing Reporting Research Research Personnel Risk Safety Severity of illness Teratology Universities Vasculitis Woman Writing alternative treatment base career career development clinical Diagnosis clinical application clinical decision-making clinically relevant cohort comparative experience fetal health care service utilization health practice improved infant morbidity/mortality infection risk innovation intraamniotic infection intrauterine infection medication safety member pediatric department perinatal outcomes programs prospective public health relevance research and development skills treatment risk

项目摘要

DESCRIPTION (provided by applicant): I am a postdoctoral scholar in the Department of Pediatrics at the University of California, San Diego (UCSD), and I am applying for the K99/R00 Pathway to Independence Award to facilitate my transition to become an independent investigator of medication safety during pregnancy. My background is in epidemiology and my career goal is to conduct research regarding the risks of medication use during pregnancy on perinatal and pediatric health to inform the complex treatment decisions that women and their health care providers must make. To develop my capacity to become an independent investigator, I am proposing an intensive career development and research program. Specifically, I propose (1) to increase my knowledge of pharmacology concepts, drug information, and human teratology, (2) to gain additional experience conducting studies using prospective cohort and healthcare utilization data and disseminating findings to healthcare professionals, and (3) to strengthen my grant writing skills. I have assembled the ideal team of 5 UCSD faculty members to provide me with guidance and instruction in these areas. My primary mentor, Dr. Christina Chambers, is a leader in the field of medication safety during pregnancy. My co-mentors are: Dr. Brookie Best, an expert in clinical pharmacology during pregnancy; Dr. Grace Kuo who has expertise in health services and practice-based research; Dr. Todd Gilmer, an expert in conducting research with Medicaid data; and Dr. Ronghui Xu, who has expertise in applying biostatistics methods to studies of medication in pregnancy. The objective of the proposed research is to inform clinical decision making regarding oral corticosteroid use versus alternative treatments for asthma and autoimmune diseases during pregnancy. I am proposing to assess the association between oral corticosteroid use during pregnancy and risk for preterm birth among pregnant women with asthma and autoimmune diseases. I will compare oral corticosteroids with alternative treatments (e.g., inhaled corticosteroids and disease modifying antirheumatic drugs) and no treatment. I will use both prospectively collected cohort data and healthcare utilization data to conduct the study, and I will compare and contrast these methodological approaches. Furthermore, I will disseminate the results, within the context of previous research, to clinicians. The proposed study is responsive to the urgent public health need for information regarding the impact of oral corticosteroid use on risk for preterm birth. I will develop expertise in working with cohort and healthcare utilization data, and will gain experience comparing study methodologies and developing clinical applications related to medication safety research. Building on this innovative research, I will develop a competitive R01 grant proposal to pursue studying commonly used medications during pregnancy that have inadequate human safety data.

描述（由申请人提供）：我是一所后科学学校，加利福尼亚大学圣地亚哥分校的儿科界。在怀孕期间，我的背景是流行病学的，我的护理和小儿健康期间妇女和卫生护理护理人员的复杂治疗研究计划。 . I have assembled the ideal Team of 5 UCSD FACULTY MEMBERS TO PROVIDE ME with guidance and Instruction in These Areas. My Primary. Mentor, Dr. CHAMBERS, IS A LEADER IN FIELD OF MEDICATION SAFETY DURING PREGNANCY. Armacology During Pregnancy; Dr. Grace HUS在卫生服务和实践研究中的专业知识；哮喘和自身免疫性的治疗在怀孕期间使用哮喘和自身免疫性的孕妇的早产在先前研究的背景下，进行研究的数据是对公共卫生的紧急研究的反应，以告知口服皮质类固醇对早产的风险。医疗保健利用数据将获得适用于医学的研究方法，我将开发竞争性的R01 R01赠款PROSAL TURSUE。