Juvenile Myositis

青少年肌炎

• 批准号: 9770482
• 负责人: James Inglese
• 金额: $ 18.63万
• 依托单位: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9770482
• 关键词: Adolescent; Affect; Autoimmune Diseases; Biological Assay; Calcinosis; Cells; Child; Collaborations; Contracture; Dermatomyositis; Disease; Environmental Risk Factor; Exanthema; Financial Support; Foundations; Gastrointestinal tract structure; Genetic; Goals; Immune system; Life; Muscle; Muscle Weakness; Myositis; Pathogenesis; Pathway interactions; Polymyositis; Skin; Symptoms; Tissues; Ulcer; base; design; experience; small molecule libraries

Juvenile myositis (JM) is an autoimmune disease targeting muscles, skin and other tissues caused by yet to be determined genetic and environmental factors. With financial support from the Cure JM Foundation in collaboration with Cure JM Foundation scientific advisors we have begun the design and develop of assays based on probably genetic anomalies that may be contributing to JM pathogenesis. These assays will be use in the interrogation of chemical libraries for the identification of agents that modify these aberrant pathways.

青少年肌炎（JM）是一种针对肌肉、皮肤和其他组织的自身免疫性疾病，由尚未确定的遗传和环境因素引起。在 Cure JM 基金会的财政支持下，我们与 Cure JM 基金会的科学顾问合作，开始根据可能导致 JM 发病机制的遗传异常设计和开发检测方法。 这些测定将用于询问化学库，以鉴定修改这些异常途径的试剂。