The Autistic Brain Over 45: The Anatomic, Functional, and Cognitive Phenotype

45 岁以上的自闭症大脑：解剖学、功能和认知表型

基本信息

批准号：
9211387
负责人：
Ralph-Axel Mueller
金额：
$ 69.1万
依托单位：
SAN DIEGO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-08 至 2021-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9211387
关键词：
Address Adolescent Adult Affect Age Age-Years Aging Alzheimer&apos s Disease Anatomy Ataxia Autistic Disorder Autopsy Awareness Behavioral Brain Characteristics Child Clinical Treatment Cognitive Control Groups Data Development Diffuse Diffusion Magnetic Resonance Imaging Disease Down Syndrome Elderly Episodic memory Equipment and supply inventories Foundations Fragile X Gene Fragile X Syndrome Frequencies Image Imaging Techniques Impairment Individual Inflammatory Response Intervention Investigation Knowledge Life Life Style Link Literature Longevity Longitudinal Studies Magnetic Resonance Imaging Measures Memory Mental disorders Motor Multimodal Imaging Neurocognitive Neurocognitive Deficit Neurodevelopmental Disorder Neurologic Neurologic Deficit Normal Range Outcome Oxidative Stress Participant Pharmaceutical Preparations Phenotype Population Preventive Intervention Probability Public Health Recommendation Recruitment Activity Research Risk Risk Factors Site Structure Subgroup Symptoms System Testing Thick Thinness Time Tremor age related autism spectrum disorder base behavior change behavior measurement brain behavior clinical imaging cognitive ability cognitive testing developmental disease diffusion weighted experience gray matter imaging modality middle age nervous system disorder prospective public health relevance rate of change relating to nervous system response skills stressor success virtual white matter young adult

项目摘要

DESCRIPTION (provided by applicant): The behavioral and neuroscientific literature on children and adolescents with autism spectrum disorder (ASD) has grown dramatically over the past decades. In contrast, almost nothing is known about ASD later in life. This is problematic in view of preliminary findings suggesting that some older people with ASD may experience accelerated cognitive and neurological decline, combined with extensive evidence of age-related complications and decline in other neurodevelopmental disorders. The present study will be the first systematic investigation of brain anatomy and connectivity in mid to late adulthood in ASD. We will recruit 100 adults with ASD, ages 45-65 years, and 80 matched neurotypical control (NC) participants, and will use anatomical, functional connectivity, and diffusion MRI as well as a battery of sensorimotor and cognitive tests in a longitudinal study, with participants returning after 2.5 years for a second time point. Specific aims will be to examine (1) brain anatomy (cortical thickness and volumes of gray matter structures, white matter, and CSF) and (2) anatomical and functional brain connectivity in adults with ASD compared to NC participants, (3) to characterize cognitive and behavioral abilities, and correlate these skills with brain structure and function, and (4) to create an extensive inventory of variables that may predict long- term neurocognitive success or decline in ASD. Analyses will be performed for a broad range of domains and networks, with some focus on executive, motor, and memory systems. Whereas aims 1-3 will provide a currently unavailable systematic body of evidence on changes in brain and behavior during mid to late adulthood in ASD, aim 4 will have strong prospective translational relevance because identification of brain sites and behavioral measures most likely to predict age-related decline vs. successful aging in ASD will be crucial for the development of preventative interventions.

描述（由申请人提供）：关于患有自闭症谱系障碍（ASD）的儿童和青少年的行为和神经科学文献在过去几十年中急剧增长，相比之下，人们对以后的自闭症谱系障碍几乎一无所知。初步研究结果表明，一些患有自闭症谱系障碍的老年人可能会经历认知和神经功能加速衰退，以及与年龄相关的并发症和其他神经发育障碍衰退的大量证据。本研究将是对中年至中年大脑解剖结构和连接性的首次系统研究。成年晚期在我们将招募 100 名年龄在 45-65 岁的 ASD 成年人和 80 名匹配的神经典型对照 (NC) 参与者，并将使用解剖学、功能连接和扩散 MRI 以及一系列纵向感觉运动和认知测试。研究，参与者在 2.5 年后第二次返回，具体目标是检查 (1) 大脑解剖结构（皮质厚度和灰质结构、白质和脑脊液的体积）和 (2)与 NC 参与者相比，患有 ASD 的成年人的解剖学和功能性大脑连接，（3）表征认知和行为能力，并将这些技能与大脑结构和功能相关联，以及（4）创建一个广泛的变量清单，这些变量可以预测长期将对广泛的领域和网络进行分析，重点关注执行、运动和记忆系统，整个目标 1-3 将提供目前无法获得的有关自闭症谱系障碍的系统性证据。中后期的大脑和行为在自闭症谱系障碍成年期，目标 4 将具有很强的前瞻性转化相关性，因为识别最有可能预测自闭症谱系障碍中与年龄相关的衰退与成功衰老的大脑部位和行为测量对于预防性干预措施的制定至关重要。