The Autistic Brain Over 45: The Anatomic, Functional, and Cognitive Phenotype

45 岁以上的自闭症大脑：解剖学、功能和认知表型

基本信息

批准号：
9211387
负责人：
Ralph-Axel Mueller
金额：
$ 69.1万
依托单位：
SAN DIEGO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-08 至 2021-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9211387
关键词：
Address Adolescent Adult Affect Age Age-Years Aging Alzheimer&apos s Disease Anatomy Ataxia Autistic Disorder Autopsy Awareness Behavioral Brain Characteristics Child Clinical Treatment Cognitive Control Groups Data Development Diffuse Diffusion Magnetic Resonance Imaging Disease Down Syndrome Elderly Episodic memory Equipment and supply inventories Foundations Fragile X Gene Fragile X Syndrome Frequencies Image Imaging Techniques Impairment Individual Inflammatory Response Intervention Investigation Knowledge Life Life Style Link Literature Longevity Longitudinal Studies Magnetic Resonance Imaging Measures Memory Mental disorders Motor Multimodal Imaging Neurocognitive Neurocognitive Deficit Neurodevelopmental Disorder Neurologic Neurologic Deficit Normal Range Outcome Oxidative Stress Participant Pharmaceutical Preparations Phenotype Population Preventive Intervention Probability Public Health Recommendation Recruitment Activity Research Risk Risk Factors Site Structure Subgroup Symptoms System Testing Thick Thinness Time Tremor age related autism spectrum disorder base behavior change behavior measurement brain behavior clinical imaging cognitive ability cognitive testing developmental disease diffusion weighted experience gray matter imaging modality middle age nervous system disorder prospective public health relevance rate of change relating to nervous system response skills stressor success virtual white matter young adult

项目摘要

DESCRIPTION (provided by applicant): The behavioral and neuroscientific literature on children and adolescents with autism spectrum disorder (ASD) has grown dramatically over the past decades. In contrast, almost nothing is known about ASD later in life. This is problematic in view of preliminary findings suggesting that some older people with ASD may experience accelerated cognitive and neurological decline, combined with extensive evidence of age-related complications and decline in other neurodevelopmental disorders. The present study will be the first systematic investigation of brain anatomy and connectivity in mid to late adulthood in ASD. We will recruit 100 adults with ASD, ages 45-65 years, and 80 matched neurotypical control (NC) participants, and will use anatomical, functional connectivity, and diffusion MRI as well as a battery of sensorimotor and cognitive tests in a longitudinal study, with participants returning after 2.5 years for a second time point. Specific aims will be to examine (1) brain anatomy (cortical thickness and volumes of gray matter structures, white matter, and CSF) and (2) anatomical and functional brain connectivity in adults with ASD compared to NC participants, (3) to characterize cognitive and behavioral abilities, and correlate these skills with brain structure and function, and (4) to create an extensive inventory of variables that may predict long- term neurocognitive success or decline in ASD. Analyses will be performed for a broad range of domains and networks, with some focus on executive, motor, and memory systems. Whereas aims 1-3 will provide a currently unavailable systematic body of evidence on changes in brain and behavior during mid to late adulthood in ASD, aim 4 will have strong prospective translational relevance because identification of brain sites and behavioral measures most likely to predict age-related decline vs. successful aging in ASD will be crucial for the development of preventative interventions.

描述（由适用提供）：自闭症谱系障碍儿童和青少年的行为和神经科学文献（ASD）在过去几十年中急剧增长。相比之下，几乎一无所知。鉴于初步发现，这是有问题的，这表明一些ASD患有ASD的老年人可能会经历加速的认知和神经系统下降，并结合了与年龄相关并发症的广泛证据和其他神经发育障碍的下降。本研究将是大脑解剖结构和成年后期的第一次系统投资 ASD。我们将招募100名ASD，年龄45-65岁的成年人和80名匹配的神经型对照（NC）参与者，并将使用解剖学，功能连通性和扩散MRI以及一系列的感觉运动和认知测试，并在参与者返回2.5年后获得第二个时间点。具体目的将是检查（1）脑解剖学（皮质厚度和灰质结构的皮质厚度和大小，白质和CSF）以及（2）与NC参与者相比，患有ASD的成年人的解剖学和功能性大脑连接性，（3）以表征认知和行为能力，并将这些技能与大脑结构和功能相关联（4或ASD下降。分析将针对各种域和网络进行，其中一定关注执行，电机和内存系统。虽然目标1-3将提供目前无法获得的有关ASD成年期中期到后期大脑和行为变化的系统证据，但AIM 4将具有很强的前瞻性翻译相关性，因为大脑站点和行为指标最有可能预测与年龄相关的衰落与ASD成功的ASD衰老对预防性干预措施的发展至关重要。