Nonlinear Models of Cognition Preceding AD and non-AD in a Biracial Population Sample

混血人群样本中 AD 和非 AD 之前的认知非线性模型

基本信息

批准号：
9339530
负责人：
Kumar B. Rajan
金额：
$ 27.13万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2018-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9339530
关键词：
Affect Age Aging Area Cardiovascular system Chicago Clinical Trials Cognition Cognition Disorders Cognitive Data Data Analyses Data Collection Dementia Development Diagnosis Disease Elderly Episodic memory Exhibits Future Genetic Growth Health Heterogeneity High Prevalence Impaired cognition Individual Investigation Life Style Linear Models Longitudinal Studies Longitudinal cohort Modeling Non-linear Models Not Hispanic or Latino Participant Phase Population Population Heterogeneity Population Study Prevention strategy Preventive Process Public Health Research Risk Risk Factors Role Sampling Shapes Standardization Testing Time Vascular Dementia Work base biracial cardiovascular risk factor clinical Diagnosis cognitive function cognitive testing cost design effective therapy epidemiology study executive function genetic risk factor health disparity interest mild cognitive impairment minority health population based pre-clinical preclinical development secondary analysis social treatment strategy

项目摘要

This proposal aims to conduct secondary analyses of existing data to examine nonlinear cognitive decline in standardized global summary of cognition assessed using executive functioning, episodic memory, and overall global cognition and orientation within the context of a large population-based study of older adults: Chicago Health and Aging Project (CHAP). More specifically, the four objectives of this proposal are: 1) Examine Nonlinear Cognitive Decline in Older Blacks and Whites Using Change Point Models in a Random Sample of 2,948 Participants with AD and non-AD Diagnosis; 2) investigate the Role of Demographic, Social, Lifestyle, Cardiovascular, and Genetic Risk Factors on Nonlinear Cognitive Decline in Older Blacks and Whites with AD and non-AD Diagnosis; 3) Identify the Heterogeneity in Nonlinear Cognitive Decline Using Latent Class Growth Curve Models Using a Population Sample of 7,757 Blacks and Whites with Multiple Cognitive Assessments; 4) Understand the Role of Demographic, Social, Lifestyle, Cardiovascular, and Genetic Risk Factors on Latent Class Memberships to Explain Heterogeneity in Nonlinear Cognitive Decline. Understanding the rate of cognitive decline in older blacks and whites has a topic of considerable interest. However, most research has focused on linear trajectories in whites with mixed findings among blacks. Nonlinear cognitive decline based on change points are nonexistent in blacks and the proposed work can increase our understanding of preclinical phase of AD and non-AD.

该提案旨在对现有数据进行二次分析，以检查非线性认知衰退使用执行功能、情景记忆和评估的标准化全球认知总结在一项针对老年人的大型人口研究背景下的总体全球认知和取向：芝加哥健康与老龄化项目（CHAP）。更具体地说，该提案的四个目标是：1) 使用随机变化点模型检查老年黑人和白人的非线性认知衰退 2,948 名患有 AD 和非 AD 诊断的参与者的样本； 2）调查人口统计的作用，老年黑人非线性认知衰退的社会、生活方式、心血管和遗传风险因素患有 AD 和非 AD 诊断的白人； 3）识别非线性认知衰退的异质性使用潜在阶级增长曲线模型，使用 7,757 名黑人和白人的人口样本多重认知评估； 4) 了解人口、社会、生活方式、心血管、潜在类别成员资格和遗传风险因素解释非线性认知的异质性衰退。了解老年黑人和白人认知能力下降的速度是一个相当重要的话题兴趣。然而，大多数研究都集中在白人的线性轨迹上，其中的结果不一。黑人。基于变化点的非线性认知衰退在黑人中不存在，并且提出的工作可以增加我们对 AD 和非 AD 临床前阶段的了解。