The impact of marijuana use on brain and cognitive function in HIV-infected patients

吸食大麻对艾滋病毒感染者大脑和认知功能的影响

基本信息

批准号：
9321496
负责人：
Tony W Wilson
金额：
$ 15.31万
依托单位：
UNIVERSITY OF NEBRASKA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9321496
关键词：
AIDS Dementia Complex AIDS/HIV problem Acquired Immunodeficiency Syndrome Administrative Supplement Affect Age-associated memory impairment Aging Anti-Retroviral Agents Area Award Brain Brain imaging Cannabis Centers for Disease Control and Prevention (U.S.)Chronic Cognitive Comorbidity Complication Consumption Country Data Disease Drug abuse Encephalitis Enrollment Exclusion Criteria Frequencies Functional Imaging Goals Grant HIV HIV Infections HIV-associated neurocognitive disorder High Prevalence Impaired cognition Incidence Investigation Learning Light Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Magnetoencephalography Maps Marijuana Marijuana Abuse Matched Group Measures Medical Marijuana Methods Microglia National Institute of Drug Abuse Neurobiology Neurocognitive Neurologic Neurophysiology - biologic function Neuropsychological Tests Neuropsychology Participant Patients Performance Population Prevalence Principal Investigator Recruitment Activity Reporting Research Research Personnel Residual state Resolution Sampling Science Scientist Seminal Severities Sex Characteristics Short-Term Memory Structure Substance abuse problem Targeted Research Viral Load result Visual attention brain abnormalities career cognitive function cognitive performance excitotoxicity imaging modality insight marijuana legalization marijuana use marijuana user millisecond multimodality neuroAIDS neurocognitive disorder neuroimaging neurophysiology novel programs temporal measurement trend

项目摘要

Project Summary/Abstract This amended R03 proposal is for a NIDA-sponsored, AIDS-Science Track Award for Research Transition (A- START; PA-15-290). The primary goal of the A-START program is to support the entry of new and early career investigators into the area of drug abuse research in HIV/AIDS, particularly those whose current research program focuses on either drug abuse or HIV/AIDS, and who now wish to expand their program and study the intersection of these two areas. The PI of the current proposal is an early career investigator who received his first R01 award in August 2014 for a multimodal neuroimaging study examining how HIV-infection modulates age-related cognitive decline. Since then, he has received an administrative supplement to expand enrollment and examine sex differences in the R01 project, and been involved in other successful grants as a co- investigator. The PI is strongly committed to a career in neuroAIDS research, and through an A-START will expand his research program into the neurobiology and neuropsychology of drug abuse in HIV/AIDS, with a long-term focus on how substance abuse affects the incidence and severity of HIV-associated neurocognitive disorders. Such disorders are the most common neurological complication of HIV disease, with prevalence estimates ranging from 35-70% of all HIV-infected patients, and research targeting such comorbidities has been identified as a top priority by the Office of AIDS Research (see NOT-OD-15-137). The primary research goals of this project are to quantify the unique neuropsychological and neurobiological consequences of chronic marijuana abuse in HIV-infected patients. To this end, we will study demographically- matched groups of HIV-infected and uninfected heavy, light, and non-users of marijuana. All participants will undergo neuropsychological testing, high-resolution structural neuroimaging, and dynamic functional imaging with magnetoencephalography (MEG). MEG is an emerging method that directly quantifies neurophysiological activity and can produce functional maps with high spatial precision and millisecond temporal resolution. Data for the HIV-infected and uninfected light and non-user groups will be collected through the PI’s R01 project, which uses the same neuropsychological and imaging methods, but considers heavy use to be an exclusion criteria. Importantly, only four studies have examined the impact of marijuana abuse on cognitive function in HIV-infected patients, and these studies reported mixed results. Further, no study to date has evaluated brain structure or function in this area. Thus, the consequences of marijuana abuse in HIV-infected patients remain largely unknown, which is especially concerning as we enter an era of marijuana legalization. In summary, this A-START project will: (a) provide seminal neuroimaging and neuropsychological data on how HIV-associated neurocognitive disorders may be affected by chronic marijuana use, (b) contribute novel insight into whether the severity of neurological complications connects with the extent of marijuana consumption (heavy vs. light), and (c) serve as a springboard for the PI to begin drug abuse research in HIV/AIDS.

项目概要/摘要修订后的 R03 提案适用于 NIDA 赞助的艾滋病科学研究转型奖 (A- START；PA-15-290) A-START 计划的主要目标是支持新的和早期职业的进入。艾滋病毒/艾滋病药物滥用研究领域的研究人员，特别是那些当前研究的研究人员计划重点关注药物滥用或艾滋病毒/艾滋病，现在希望扩大其计划并研究当前提案的 PI 是一位早期职业调查员，他获得了他的学位。 2014 年 8 月，一项研究 HIV 感染如何调节的多模式神经影像研究荣获首个 R01 奖从那时起，他就接受了扩大招生的行政补助。并检查 R01 项目中的性别差异，并作为共同参与者参与了其他成功的资助 PI 坚定致力于神经艾滋病研究事业，并通过 A-START 意愿。将他的研究项目扩展到艾滋病毒/艾滋病药物滥用的神经生物学和神经心理学，长期关注药物滥用如何影响艾滋病毒相关神经认知的发生率和严重程度此类疾病是艾滋病毒疾病最常见的神经系统并发症，且普遍存在。据估计，所有 HIV 感染者中 35-70% 的患者都患有这种疾病，针对此类合并症的研究已经已被艾滋病研究办公室确定为首要任务（参见 NOT-OD-15-137）。该项目的主要研究目标是量化独特的神经心理学和神经生物学艾滋病毒感染者长期滥用大麻的后果为此，我们将从人口统计学角度进行研究。艾滋病毒感染者和未感染者、重度、轻度和不吸食大麻的匹配组。接受神经心理学测试、高分辨率结构神经成像和动态功能成像脑磁图（MEG）是一种直接量化神经生理学的新兴方法。活动并可以生成具有高空间精度和毫秒时间分辨率的功能图。对于 HIV 感染者和未感染者以及非使用者群体，将通过 PI 的 R01 项目收集，它使用相同的神经心理学和成像方法，但认为大量使用是一种排除重要的是，只有四项研究探讨了大麻滥用对认知功能的影响。艾滋病毒感染者的大脑，这些研究报告的结果好坏参半。此外，迄今为止还没有研究评估过大脑。因此，艾滋病毒感染者滥用大麻的后果仍然存在。很大程度上不为人知，随着我们进入大麻合法化时代，这一点尤其令人担忧。 A-START 项目将：(a) 提供有关 HIV 相关性的重要神经影像学和神经心理学数据神经认知障碍可能会受到长期吸食大麻的影响，(b) 提供新的见解：神经系统并发症的严重程度与吸食大麻的程度有关（重度与轻度）， (c) 作为 PI 开展艾滋病毒/艾滋病药物滥用研究的跳板。