The impact of marijuana use on brain and cognitive function in HIV-infected patients

吸食大麻对艾滋病毒感染者大脑和认知功能的影响

基本信息

批准号：
9321496
负责人：
Tony W Wilson
金额：
$ 15.31万
依托单位：
UNIVERSITY OF NEBRASKA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9321496
关键词：
AIDS Dementia Complex AIDS/HIV problem Acquired Immunodeficiency Syndrome Administrative Supplement Affect Age-associated memory impairment Aging Anti-Retroviral Agents Area Award Brain Brain imaging Cannabis Centers for Disease Control and Prevention (U.S.)Chronic Cognitive Comorbidity Complication Consumption Country Data Disease Drug abuse Encephalitis Enrollment Exclusion Criteria Frequencies Functional Imaging Goals Grant HIV HIV Infections HIV-associated neurocognitive disorder High Prevalence Impaired cognition Incidence Investigation Learning Light Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Magnetoencephalography Maps Marijuana Marijuana Abuse Matched Group Measures Medical Marijuana Methods Microglia National Institute of Drug Abuse Neurobiology Neurocognitive Neurologic Neurophysiology - biologic function Neuropsychological Tests Neuropsychology Participant Patients Performance Population Prevalence Principal Investigator Recruitment Activity Reporting Research Research Personnel Residual state Resolution Sampling Science Scientist Seminal Severities Sex Characteristics Short-Term Memory Structure Substance abuse problem Targeted Research Viral Load result Visual attention brain abnormalities career cognitive function cognitive performance excitotoxicity imaging modality insight marijuana legalization marijuana use marijuana user millisecond multimodality neuroAIDS neurocognitive disorder neuroimaging neurophysiology novel programs temporal measurement trend

项目摘要

Project Summary/Abstract This amended R03 proposal is for a NIDA-sponsored, AIDS-Science Track Award for Research Transition (A- START; PA-15-290). The primary goal of the A-START program is to support the entry of new and early career investigators into the area of drug abuse research in HIV/AIDS, particularly those whose current research program focuses on either drug abuse or HIV/AIDS, and who now wish to expand their program and study the intersection of these two areas. The PI of the current proposal is an early career investigator who received his first R01 award in August 2014 for a multimodal neuroimaging study examining how HIV-infection modulates age-related cognitive decline. Since then, he has received an administrative supplement to expand enrollment and examine sex differences in the R01 project, and been involved in other successful grants as a co- investigator. The PI is strongly committed to a career in neuroAIDS research, and through an A-START will expand his research program into the neurobiology and neuropsychology of drug abuse in HIV/AIDS, with a long-term focus on how substance abuse affects the incidence and severity of HIV-associated neurocognitive disorders. Such disorders are the most common neurological complication of HIV disease, with prevalence estimates ranging from 35-70% of all HIV-infected patients, and research targeting such comorbidities has been identified as a top priority by the Office of AIDS Research (see NOT-OD-15-137). The primary research goals of this project are to quantify the unique neuropsychological and neurobiological consequences of chronic marijuana abuse in HIV-infected patients. To this end, we will study demographically- matched groups of HIV-infected and uninfected heavy, light, and non-users of marijuana. All participants will undergo neuropsychological testing, high-resolution structural neuroimaging, and dynamic functional imaging with magnetoencephalography (MEG). MEG is an emerging method that directly quantifies neurophysiological activity and can produce functional maps with high spatial precision and millisecond temporal resolution. Data for the HIV-infected and uninfected light and non-user groups will be collected through the PI’s R01 project, which uses the same neuropsychological and imaging methods, but considers heavy use to be an exclusion criteria. Importantly, only four studies have examined the impact of marijuana abuse on cognitive function in HIV-infected patients, and these studies reported mixed results. Further, no study to date has evaluated brain structure or function in this area. Thus, the consequences of marijuana abuse in HIV-infected patients remain largely unknown, which is especially concerning as we enter an era of marijuana legalization. In summary, this A-START project will: (a) provide seminal neuroimaging and neuropsychological data on how HIV-associated neurocognitive disorders may be affected by chronic marijuana use, (b) contribute novel insight into whether the severity of neurological complications connects with the extent of marijuana consumption (heavy vs. light), and (c) serve as a springboard for the PI to begin drug abuse research in HIV/AIDS.

项目摘要/摘要该修订的R03提案是针对NIDA赞助的，辅助科学轨道研究过渡奖的提案（A- 开始; PA-15-290）。 A-start计划的主要目标是支持新的和早期职业的进入研究人员研究了艾滋病毒/艾滋病的药物滥用研究领域，尤其是那些目前研究的人计划专注于滥用药物或艾滋病毒/艾滋病，现在希望扩大计划并研究这两个区域的交集。当前建议的PI是一名早期职业调查员，他收到了他的 2014年8月的第一届R01奖，用于一项多模式神经影像学研究，研究HIV感染如何调节与年龄有关的认知下降。从那以后，他收到了一项行政补品以扩大注册并检查R01项目中的性别差异，并参与了其他成功的赠款研究者。 PI强烈致力于神经辅助研究的职业，并通过A-Start Will 将他的研究计划扩展到艾滋病毒/艾滋病中药物滥用的神经生物学和神经心理学，长期关注药物滥用如何影响与HIV相关神经认知的事件和严重性疾病。这种疾病是HIV疾病最常见的神经系统并发症，患病率估计范围为35-70％的所有HIV感染患者，针对此类合并症的研究具有艾滋病研究办公室被确定为重中之重（请参见Not-OD-15-137）。该项目的主要研究目标是量化独特的神经心理学和神经生物学慢性大麻滥用艾滋病毒感染患者的后果。为此，我们将在人口统计学上研究匹配的艾滋病毒感染和未感染的大麻的重量和非用户。所有参与者都会接受神经心理学测试，高分辨率结构神经影像学和动态功能成像具有磁脑摄影（MEG）。 MEG是一种直接量化神经生理学的新兴方法活性并可以产生具有高空间精度和毫秒临时分辨率的功能图。数据对于HIV感染和未感染的光线和非用户组，将通过PI的R01项目收集它使用相同的神经心理学和成像方法，但认为重量用途是排除标准。重要的是，只有四项研究检查了大麻滥用对认知功能的影响 HIV感染的患者，这些研究报告了混合的结果。此外，迄今尚无研究评估大脑该区域的结构或功能。那就，大麻滥用艾滋病毒感染患者的后果仍然存在在我们进入大麻合法化时代时，这在很大程度上是未知的。总而言之，这启动项目将：（a）提供有关艾滋病毒相关的神经影像学和神经心理学数据神经认知疾病可能会受到慢性大麻使用的影响，（b）有助于新见解神经系统并发症的严重程度与大麻消耗的程度（重与光）相关联，（c）作为PI开始在艾滋病毒/艾滋病中开始吸毒研究的跳板。