2/2-GEOHealth Hub-Improving Agricultural Health in Southeast Asia-US

2/2-GEOHealth Hub-改善东南亚-美国农业健康

• 批准号: 9331768
• 负责人: Pornpimol Kongtip
• 金额: $ 28.33万
• 依托单位: UNIVERSITY OF MASSACHUSETTS LOWELL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-28 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9331768
• 关键词: Acute; Adrenal Glands; Adrenal hormone preparation; Agricultural Workers; Agriculture; Area; Biological Markers; Chronic Disease; Coronary heart disease; Cross-Sectional Studies; Data; Data Collection; Development; Diabetes Mellitus; Disease; Economics; Educational workshop; Endocrine; Endocrine Disruptors; Environmental Health; Event; Exposure to; Extramural Activities; Faculty; Funding; Future; Genetic Polymorphism; Grant; Health; Health Policy; Healthcare Systems; Herbicides; Homeostasis; Hormones; Hypothalamic structure; Informal Sectors; Insecticides; Institution; Interdisciplinary Study; International; Link; Manuscripts; Massachusetts; Medical Staff; Mentors; Mentorship; Metabolic Diseases; Metabolic syndrome; Metabolism; Occupational Health; Occupational Safety; Occupations; Pesticides; Pilot Projects; Pituitary Gland; Policies; Population; Public Health; Publications; Recruitment Activity; Research; Research Project Grants; Research Training; Risk; Security; Southeastern Asia; Stroke; Thailand; Thyroid Gland; Training; Training Programs; Universities; Work; climate change; design; farmer; hypothalamic-pituitary-adrenal axis; hypothalamic-pituitary-thyroid axis; improved; institutional capacity; member; neurobehavioral; novel strategies; programs; southeast Asian; tool; web site; Acute; Adrenal Glands; Adrenal hormone preparation; Agricultural Workers; Agriculture; Area; Biological Markers; Chronic Disease; Coronary heart disease; Cross-Sectional Studies; Data; Data Collection; Development; Diabetes Mellitus; Disease; Economics; Educational workshop; Endocrine; Endocrine Disruptors; Environmental Health; Event; Exposure to; Extramural Activities; Faculty; Funding; Future; Genetic Polymorphism; Grant; Health; Health Policy; Healthcare Systems; Herbicides; Homeostasis; Hormones; Hypothalamic structure; Informal Sectors; Insecticides; Institution; Interdisciplinary Study; International; Link; Manuscripts; Massachusetts; Medical Staff; Mentors; Mentorship; Metabolic Diseases; Metabolic syndrome; Metabolism; Occupational Health; Occupational Safety; Occupations; Pesticides; Pilot Projects; Pituitary Gland; Policies; Population; Public Health; Publications; Recruitment Activity; Research; Research Project Grants; Research Training; Risk; Security; Southeastern Asia; Stroke; Thailand; Thyroid Gland; Training; Training Programs; Universities; Work; climate change; design; farmer; hypothalamic-pituitary-adrenal axis; hypothalamic-pituitary-thyroid axis; improved; institutional capacity; member; neurobehavioral; novel strategies; programs; southeast Asian; tool; web site

 DESCRIPTION (provided by applicant): In our planning grant we found that agricultural workers in Thailand (42% of the working population) were self- employed (informal sector), with little economic security, no formal occupational health & safety protections and significant exposures to pesticides. Thus they represent a population in need of research to policy initiatives. The initial research of our GEOHealth HUB (Mahidol University, Thailand & University of Massachusetts, USA) will focus on the agricultural health research question of whether some pesticides, widely used in Southeast Asian agriculture, act as endocrine disrupters, altering endocrine hormone homeostasis and resulting in increased risk of metabolic syndrome and associated diseases such as diabetes, stroke and coronary heart disease, all of which are on the rise in Thailand. In the paired research application (1/2-GEOHealth HUB: Improving Agricultural Health in Southeast Asia-Thailand), we hypothesize that disruption of the hypothalamic-pituitary-thyroid (HPT) axis and hypothalamic-pituitary-adrenal (HPA) axis hormone homeostasis is a biomarker of risk for the development of metabolic disorders, and that several widely used pesticides act as HPT/HPA disrupters. To evaluate our hypothesis we will: 1) Use the Thai Universal Health Care System data to conduct a cross-sectional study of metabolic disorders by occupation; 2) Evaluate sub-chronic changes in HPT & HPA hormones longitudinally among Thai organic and pesticide using farmers; 3) Examine the acute endocrine impacts of pesticide spraying events for selected insecticides & herbicides; 4) Evaluate the impact of genetic polymorphisms on pesticide metabolism. This proposed research project represents the initial focus of our GEOHealth Hub, but future projects will extend the range of agricultural health research and expand into other related occupational & environmental health topics (climate change, other chronic diseases, neurobehavioral health and other work sectors). The matched training program for the GEOHealth Hub focuses on institutional capacity building through a program of mentored research training for 15 junior faculty and medical staff over 5 years at our partner institutions (initially Mahidol University and the Thai Ministry of Public Health). Each trainee will have a Mentorship Team (Thai and U.S. mentors). The training program will include: a) 1 month Introduction to GEOHealth program at Mahidol; b) 6 months of research specific training and mentorship in the U.S. (UMass, Rutgers or Mt. Sinai), resulting in a funded interdisciplinary project that extends the research being conducted in the paired research application; c) data collection, analysis and manuscript(s) from the approved research project, supported by Mentorship Team. The program is designed to establish an international, interdisciplinary collaborative research group that will continue to work together in the future. The training program will link with our proposed research project through extensions of the current project aims and pilot projects that extend the scope of the research in agricultural health, aiding the GEOHealth Hub to expand its research capacity. As the Hub develops, we will add new training partners from other Thai and Southeast Asian universities and institutions. We will use short term training to recruit future institutional partners through existing public healt networks (ThaiPHEIN, SEAPHEIN & APACPH) and to create opportunities for Hub members to interact and develop ideas for new approaches to agricultural health research. Research findings and tools, as well as training materials will be disseminated via our website and through our short term training workshops and seminars. We expect increased research capacity will be reflected in publications (number and quality), extramural funding, multidisciplinary collaborations, development of new research areas and agricultural health policy changes.

 描述（由应用程序提供）：在我们的计划赠款中，我们发现泰国的农业工人（占工作人群的42％）是自雇（非正式部门），几乎没有经济安全，没有正式的职业健康与安全保护和对农药的重大风险。他们代表需要研究政策计划的人群。我们马萨诸塞州马萨诸塞州的地卫生枢纽（泰国和大学）的初步研究将重点放在农业健康研究问题上，即某些农药在东南亚农业中广泛使用，是否在内分泌中分泌群体造成内分泌厌恶者，改变内分泌的稳态，并导致疾病的风险增加，并导致疾病的疾病和相关的疾病，并且是对疾病的疾病，并且是对代理综合症的疾病，并且会导致疾病，并且会导致疾病，并具有代表性疾病。所有这些都在泰国上升。在配对的研究应用程序（1/2-地球卫生中心：东南亚 - 泰国的农业健康改善）中，我们假设下丘脑 - 垂体 - 甲状腺甲状腺轴（HPT）轴和下丘脑 - 腹膜 - 肾上腺 - 肾上腺 - 肾上腺辅助 - 骑士（HPA）Axise骑士式稳态的危险是In-Bigosers the Bibyard severipers the Bigomarkers的发展，这是一种疾病，是该疾病的发展，该疾病是一种习惯，该疾病的发展是nibaber and Bigoseraker的纽约，该疾病是一种习惯，该疾病的发展是nibaber the Bigoseraker的习惯。农药充当HPT/HPA的烦恼。为了评估我们的假设，我们将：1）使用泰国通用卫生保健系统数据通过事件对代谢性疾病进行横断面研究； 2）使用农民在泰国有机和农药中纵向评估HPT＆HPA辣椒的次语变化； 3）检查针对选定杀虫剂和除草剂的农药喷涂事件的急性内分泌影响； 4）评估遗传多态性对农药代谢的影响。该提出的研究项目代表了我们的地理健康枢纽的最初重点，但是未来的项目将扩展农业健康研究的范围，并扩展到其他相关的职业和环境健康主题（气候变化，其他慢性疾病，神经行为健康和其他工作部门）。 Geohealth Hub的匹配培训计划着重于通过合作机构（最初是Mahidol University和Thai公共卫生部）的5年来为15名初级教职员工和医务人员提供的指导研究培训计划的机构能力建设。每个学员将有一个指导团队（泰国和美国导师）。培训计划将包括：a）Mahidol的1个月地卫生计划简介； b）在美国进行了6个月的研究特定培训和指导（UMass，Rutgers或Sinai山），导致了一个资助的跨学科项目，该项目扩展了在配对的研究申请中进行的研究； c）由指导团队支持的批准研究项目的数据收集，分析和手稿。该计划旨在建立一个国际跨学科的合作研究小组，将来将继续合作。该培训计划将通过扩展当前项目的目标和试点项目的扩展与我们拟议的研究项目联系，这些项目扩展了农业健康研究范围，并帮助地球健康枢纽扩大了其研究能力。作为枢纽的发展，我们将添加来自其他泰国和东南亚大学和机构的新培训伙伴。我们将使用短期培训通过现有的公共卫生网络（Thaiphein，Seaphein＆ApaCPH）来招募未来的机构合作伙伴，并为枢纽成员创造机会，以互动和发展新方法的农业健康研究方法。研究发现和工具以及培训材料将通过我们的网站以及我们的短期培训研讨会和半手来传播。我们预计，研究能力的提高将反映在出版物（数量和质量），校外资金，多学科合作，新研究领域的发展和农业健康政策变化中。