Self-regulation as a Health-Protective Factor in Adverse Socioeconomic Conditions

自我调节作为不利社会经济条件下的健康保护因素

基本信息

批准号：
8646328
负责人：
Camelia E Hostinar Caudill
金额：
$ 5.08万
依托单位：
NORTHWESTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-01 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8646328
关键词：
Address Adolescent Adult Age Aging Alcohol consumption Anti-Inflammatory Agents Anti-inflammatory Behavior Biological Biological Markers C-reactive protein Cardiovascular Diseases Characteristics Child Child Development Childhood Cholesterol Chronic Chronic Disease Cognition Crowding Data Diabetes Mellitus Disadvantaged Disease Emotions Exercise Exposure to Female Female Adolescents Fostering Functional disorder Gender Gene Expression Genes Genetic Genetic Transcription Glucose Glycosylated Hemoglobin Goals Health Health behavior Hygiene Immune Individual Individual Differences Inflammation Inflammatory Inflammatory Response Pathway Informal Social Control Insulin Interleukin-6 Interpersonal Violence Intervention Knowledge Laboratories Life Life Stress Link Literature Longevity Lung diseases Malignant Neoplasms Marmota Measures Mental Depression Mentorship Metabolic Metabolic Marker Metabolic syndrome Mission Morbidity - disease rate Non-Insulin-Dependent Diabetes Mellitus Occupations Outcome Parenting behavior Pathway interactions Patient Self-Report Pharmaceutical Preparations Phenotype Pollution Population Poverty Premature Mortality Prevalence Public Health Reporting Research Risk Risk Factors Role Sample Size Sampling Self-control as a personality trait Shapes Sleep Smoking Social Functioning Socioeconomic Status Stimulus Stress Testing Thinking Time Tobacco use Training Triglycerides Universities age group aged cytokine experience follow-up health disparity indexing inflammatory marker longitudinal design low socioeconomic status mortality prevent programs prospective protective effect psychobiologic psychoimmunology public health relevance resilience response skills social socioeconomics stressor toxicant

项目摘要

DESCRIPTION (provided by applicant): Socioeconomic disadvantage is a significant risk factor for numerous lifespan health problems, including respiratory and cardiovascular disease, psychiatric illness, diabetes, and cancer. Despite the public health significance of reducing the prevalence of these conditions, there is a major gap in the literature regarding factors that may offset the risks posed by low socioeconomic status (SES). The present projects examine the extent to which self-regulation skills (the ability to intentionally control one's thoughts, emotios, and behavior) statistically interact with low SES to predict (Study 1) or associate with (Study 2) biological markers predictive of later health outcomes. This possibility is supported by child development studies showing protective effects of high self-regulatory abilities for the social functioning of children living in poverty, and reported correlations between measures of self-control and adult health outcomes. These issues will be examined using data from two completed projects (PI: Miller). Study 1 prospectively followed 147 adolescent girls (ages 15-19) for 2.5 years, assessing SES and self-regulation skills at baseline, as well as immune and metabolic risk factors every 6 months for the follow-up duration. Study 2 cross-sectionally assessed current SES, childhood parental occupation, self-regulation, immune and metabolic biomarkers in a sample of 420 adults (ages 15-55). Health risk was measured by both studies through comprehensive assessments of inflammation at multiple levels (including RNA expression, ex vivo cytokine responses to bacterial stimuli, and markers of systemic inflammation such as circulating levels of C-reactive protein and Interleukin-6) and indices of metabolic risk (levels of glucose, insulin, triglycerides, cholesterol fractions, and glycosylated hemoglobin). Aim 1 is to test if adolescent self-regulation skills moderate associations between low SES and subsequent immune and metabolic biomarker trajectories from 6-30 months post-baseline (Study 1). Aim 2 examines linear associations of low SES, self-regulation, and their statistical interaction with inflammation and metabolic dysfunction in Study 2. The third aim examines correlations between self-regulation and health practices in Study 2 (e.g., alcohol and tobacco use, medications, exercise, sleep hygiene) and explores whether results in Aim 2 hold true after controlling for health practices. These aims are directly relevant for the mission of th sponsoring agency, as they provide knowledge about a potentially health-protective factor that could help reduce the burden of morbidity and premature mortality on the population. Importantly, this protective factor has been shown to be malleable in childhood interventions. This project is part of a training plan that will provide the applicant with exemplary research, didactic, and hands-on laboratory training in psychoimmunology under the mentorship of Dr. Gregory E. Miller at Northwestern University. This training will allow the applicant to pursue her long-term research goals of investigating the links between early life stress and health across the lifespan.

描述（由申请人提供）：社会经济劣势是许多终生健康问题的一个重要风险因素，包括呼吸系统和心血管疾病、精神疾病、糖尿病和癌症。尽管降低这些疾病的患病率对公共卫生具有重要意义，但有关可能抵消低社会经济地位（SES）带来的风险的因素的文献中存在重大空白。目前的项目研究了自我调节技能（有意识地控制一个人的思想、情绪和行为的能力）与低社会经济地位的统计相互作用程度，以预测（研究 1）或与（研究 2）预测以后健康的生物标志物相关联结果。这种可能性得到了儿童发展研究的支持，这些研究表明高度的自我调节能力对生活在贫困中的儿童的社会功能具有保护作用，并报告了自我控制措施与成人健康结果之间的相关性。这些问题将使用两个已完成项目的数据进行检查（PI：米勒）。研究 1 对 147 名青春期女孩（15-19 岁）进行了为期 2.5 年的前瞻性随访，在基线时评估 SES 和自我调节技能，并在随访期间每 6 个月评估一次免疫和代谢风险因素。研究 2 以 420 名成年人（15-55 岁）为样本，对当前的 SES、童年父母职业、自我调节、免疫和代谢生物标志物进行了横断面评估。两项研究均通过对多个水平的炎症（包括 RNA 表达、体外细胞因子对细菌刺激的反应以及全身炎症标志物，如 C 反应蛋白和白细胞介素 6 的循环水平）和炎症指数的综合评估来衡量健康风险。代谢风险（葡萄糖、胰岛素、甘油三酯、胆固醇分数和糖化血红蛋白的水平）。目标 1 是测试青少年自我调节技能是否调节低 SES 与基线后 6-30 个月的免疫和代谢生物标志物轨迹之间的关联（研究 1）。目标 2 检查研究 2 中低 SES、自我调节及其与炎症和代谢功能障碍的统计相互作用的线性关联。第三个目标检查研究 2 中自我调节与健康实践（例如饮酒和吸烟、药物治疗）之间的相关性。、锻炼、睡眠卫生），并探讨在控制健康实践后目标 2 的结果是否成立。这些目标与赞助机构的使命直接相关，因为它们提供了有关潜在健康保护因素的知识，有助于减轻人口发病率和过早死亡的负担。重要的是，这种保护因素已被证明在儿童干预中具有可塑性。该项目是培训计划的一部分，该计划将在西北大学 Gregory E. Miller 博士的指导下为申请人提供心理免疫学方面的示范性研究、教学和实践实验室培训。该培训将使申请人能够实现其长期研究目标，即调查早期生活压力与整个生命周期健康之间的联系。