DNA Methylation, Preterm Birth and Blood Pressure in African American Children

非裔美国儿童的 DNA 甲基化、早产和血压

基本信息

批准号：
9450606
负责人：
Veronica Barcelona
金额：
$ 9.27万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-19 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9450606
关键词：
37 weeks gestation 5 year old Address Adult Affect African American Appointment Area Attention Biological Birth Blood Pressure Body mass index Candidate Disease Gene Cardiovascular Diseases Cardiovascular system Caucasians Cessation of life Child Chronic Disease Clinical Clinical Research Cohort Studies DNA DNA Methylation Data Data Analyses Development Discipline of Nursing Disease Environment Environmental Exposure Epidemiologist Epidemiology Epigenetic Process Ethnic group Etiology Fetus Foundations Future Genes Genetic Genomics Goals Health Hypertension Individual Investigation Knowledge Learning Life Cycle Stages Life Expectancy Long-Term Effects Longitudinal Studies Maternal and Child Health Measures Mediating Mentored Research Scientist Development Award Mentorship Metabolic Diseases Methylation Minority Groups Mission Molecular Genetics Morbidity - disease rate Mothers Nurses Obesity Outcome Overweight Parents Participant Population Precision Medicine Initiative Predisposition Pregnancy Premature Birth Process Psychological Factors Public Health Public Health Nurses Public Health Nursing Quantitative Genetics Recruitment Activity Reproductive Health Research Research Personnel Risk Risk Factors School Nursing Strategic Planning The Sun Therapeutic Intervention Time Training Training Programs United States Universities Ursidae Family Veronica Work blood lead cardiovascular health cardiovascular risk factor career cohort disorder risk environmental stressor epigenome epigenomics ethnic minority population experience fetal genetic epidemiology health disparity heart disease risk high risk innovation intergenerational knowledge base lens methyl group mortality parent grant perinatal health personalized medicine premature prevent professor racial and ethnic stressor tenure track

37 weeks gestation 5 year old Address Adult Affect African American Appointment Area Attention Biological Birth Blood Pressure Body mass index Candidate Disease Gene Cardiovascular Diseases Cardiovascular system Caucasians Cessation of life Child Chronic Disease Clinical Clinical Research Cohort Studies DNA DNA Methylation Data Data Analyses Development Discipline of Nursing Disease Environment Environmental Exposure Epidemiologist Epidemiology Epigenetic Process Ethnic group Etiology Fetus Foundations Future Genes Genetic Genomics Goals Health Hypertension Individual Investigation Knowledge Learning Life Cycle Stages Life Expectancy Long-Term Effects Longitudinal Studies Maternal and Child Health Measures Mediating Mentored Research Scientist Development Award Mentorship Metabolic Diseases Methylation Minority Groups Mission Molecular Genetics Morbidity - disease rate Mothers Nurses Obesity Outcome Overweight Parents Participant Population Precision Medicine Initiative Predisposition Pregnancy Premature Birth Process Psychological Factors Public Health Public Health Nurses Public Health Nursing Quantitative Genetics Recruitment Activity Reproductive Health Research Research Personnel Risk Risk Factors School Nursing Strategic Planning The Sun Therapeutic Intervention Time Training Training Programs United States Universities Ursidae Family Veronica Work blood lead cardiovascular health cardiovascular risk factor career cohort disorder risk environmental stressor epigenome epigenomics ethnic minority population experience fetal genetic epidemiology health disparity heart disease risk high risk innovation intergenerational knowledge base lens methyl group mortality parent grant perinatal health personalized medicine premature prevent professor racial and ethnic stressor tenure track

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项目摘要

PROJECT SUMMARY/ABSTRACT Dr. Veronica Barcelona de Mendoza is a Postdoctoral Associate at Yale School of Nursing and a nationally certified Advanced Public Health Nurse. She will begin her appointment as Assistant Professor on the tenure track at Yale School of Nursing beginning July 2017. As a public health nurse and epidemiologist, Dr. Barcelona de Mendoza has a strong clinical and research background in perinatal and reproductive health and health disparities. The candidate proposes to expand her knowledge base to include genetic epidemiology and cardiovascular genomics through participation in courses and training programs in genetic data analysis and quantitative genetics. Long-term goals include (a) examination of health disparities in maternal/child health from a life course perspective, (b) utilization of an epigenomic approach in the reduction of reproductive health disparities, and (c) investigation of the associations between cardiovascular health, genomics and reproductive health, with a life course focus. In order to achieve these long-term goals, Dr. Barcelona de Mendoza proposes to study the associations of DNA methylation, obesity and preterm birth on blood pressure in African American children. The proposed project will recruit participants from an ongoing R01 cohort study examining the interaction between genomic and environmental stressors on blood pressure in African American mothers and children. The project's specific aims are to: (1) Examine how DNAm of candidate genes mediates the association between preterm birth and blood pressure among 3-5 year old African American children (2) Investigate how DNAm of candidate genes mediates the association between BMI and blood pressure in African American children, and (3) repeat epigenetic analyses to examine the association between DNAm, PTB and BMI on BP over time (approximately two years) (exploratory aim). Yale University provides a rich and supportive research environment for the candidate to conduct this study. Under the excellent mentorship of Drs. Jackie Taylor (genomics), Yan Sun (statistical genetics), Andrew DeWan (genetic epidemiology) and Ann Kurth (reproductive health), the candidate will receive the necessary support to complete this project. This project is in line with the NINR's key theme of “Wellness: Promoting Health and Preventing Illness”, and the cross-cutting area of “Promoting Innovation” through personalized medicine and genomics. These strategic themes are addressed in this project by investigating the physical and environmental causes of health disparities in preterm birth and cardiovascular disease as major contributors of morbidity and mortality within a high risk racial/ethnic minority group. The candidate will build upon previous work in perinatal health disparities by adding advanced training in molecular genetics, genetic epidemiology and quantitative genetics, expanding the lens through which to study the public health problem of preterm birth. By receiving the additional training and excellent mentorship outlined in this proposal, Dr. Barcelona de Mendoza will be well-prepared as a successful independent investigator to reduce maternal/child health disparities.

项目摘要/摘要 Veronica Barcelona de Mendoza博士是耶鲁大学护理学院的博士后助理和全国性的经过认证的高级公共卫生护士。她将开始任命任期的助理教授从2017年7月开始，耶鲁大学护理学院的曲目。作为公共卫生护士和流行病学家，博士巴塞罗那德·门多萨（Mendoza）在围产期和生殖健康方面具有强大的临床和研究背景健康差异。候选人提出的提议将其知识基础扩展到包括遗传流行病学和通过参加遗传数据分析的课程和培训计划，心血管基因组学和定量遗传学。长期目标包括（a）孕产妇/儿童健康中健康差异从人生课程的角度来看，（b）利用表观基因组方法在降低繁殖健康中差异，以及（c）对心血管健康，基因组学和生殖之间关联的研究健康，重点是人生课程。为了实现这些长期目标，巴塞罗那de Mendoza博士提案研究非裔美国人的血压，肥胖和早产DNA甲基化的关联孩子们。拟议的项目将招募正在进行的R01队列研究的参与者研究基因组和环境压力源对非裔美国母亲血压的相互作用以及孩子们。该项目的具体目的是：（1）检查候选基因的dnam如何介导 3-5岁的非洲裔美国儿童的早产与血压之间的关联（2）研究候选基因dnam如何介导BMI与血压之间的关联非洲裔美国儿童和（3）重复表观遗传分析，以检查Dnam之间的关联， PTB和BMI随着时间的推移（大约两年）（探索目的）。耶鲁大学提供富人和候选人进行这项研究的支持性研究环境。在出色的心态博士。杰基·泰勒（Jackie Taylor）（基因组学），Yan Sun（统计遗传学），Andrew Dewan（遗传流行病学）和ANN 库斯（繁殖健康），候选人将获得必要的支持以完成该项目。项目符合宁尔的关键主题“健康：促进健康和预防疾病”，以及通过个性化医学和基因组学促进“促进创新”的横切领域。这些策略通过研究健康的身体和环境原因来解决该项目的主题早产和心血管疾病的差异是在高风险种族/少数民族群体。候选人将基于以前的围产期健康差异的工作通过增加分子遗传学，遗传流行病学和定量遗传学的先进训练，扩大研究早产的公共卫生问题的镜头。通过接受额外的培训在该提案中概述了出色的精明制度，巴塞罗那德·门多萨（Barcelona de Mendoza）博士将得到充分准备成功的独立研究者减少母婴健康分布。