Cerebral Small Vessels in Motor and Cognitive Decline

运动和认知能力下降的大脑小血管

基本信息

批准号：
9063148
负责人：
FARZANEH A SOROND
金额：
$ 44.7万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-01 至 2018-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9063148
关键词：
Appearance Biological Markers Blood Vessels Boston Brain Brain Injuries Brain imaging Cerebral small vessel disease Cerebrovascular Disorders Cerebrum Clinical Clinical Trials Clinical assessments Cognition Cognitive Data Data Analyses Dementia Development Disease Progression Doppler Ultrasound Elderly Epidemiology Future Gait Gait speed Goals Health Homeostasis Impaired cognition Impairment Incidence Individual Knowledge Lacunar Infarctions Lead Lesion Link Magnetic Resonance Imaging Measures Mediating Microvascular Dysfunction Monitor Motor Onset of illness Outcome Pain Participant Population Prevention Preventive Intervention Process Public Health Research Role Testing Therapeutic Intervention Vascular Diseases White Matter Hyperintensity age related aging population base burden of illness cerebral microbleeds cerebrovascular cohort design disability falls follow-up functional outcomes indexing meter motor impairment neurovascular coupling novel therapeutics population based pre-clinical predictive marker programs

项目摘要

DESCRIPTION (provided by applicant): Cognitive and motor impairments are the two most common causes of disability in older adults. These two problems can lead to disabling forms of dementia and falls. Age-related cognitive and mobility impairments are clearly multifactorial, but with the rampant incidence of vascular disease in an aging population we cannot underestimate the role of cerebrovascular disease in age-related mobility disability and cognitive decline. Increasing evidence from epidemiological and clinico-pathological studies has established a strong link between vascular disease, particularly cerebral small vessel disease and the age- related clinical outcomes of cognitive and mobility impairment. However, our current research and knowledge is based on surrogate radiographic measure of small vessel disease which are mostly irreversible. The overall goal of this study is to identify vascular measures of cerebral small vessels which precede the onset of cognitive and motor decline and are predictive of clinical and radiographic outcomes in small vessel disease. Such measures would allow us to identify individuals in the pre-clinical state when our prevention and therapeutic interventions could have a higher impact. Moreover, these measures can also be used in future clinical trials to monitor disease progression and to evaluate new therapies.

描述（由申请人提供）：认知和运动障碍是老年人残疾的两个最常见原因。这两个问题可能导致残疾的痴呆和跌倒。与年龄相关的认知和流动性障碍显然是多因素的，但是由于老龄化人口中血管疾病的发生率猖ramp，因此我们不能低估脑血管疾病在与年龄相关的流动性残疾和认知能力下降中的作用。流行病学和临床病理学研究的越来越多的证据在血管疾病（尤其是脑小血管疾病与与年龄相关的认知和流动性障碍的临床结果）之间建立了牢固的联系。但是，我们当前的研究和知识是基于对小血管疾病的替代射线照相量度，这些疾病大多是不可逆转的。这项研究的总体目的是确定在认知和运动衰落开始之前的脑小血管的血管测量，并预测了小血管疾病的临床和射线照相结果。当我们的预防和治疗干预措施可能产生更高的影响时，这种措施将使我们能够识别出临床前状态的个人。此外，这些措施也可以在以后的临床试验中使用，以监测疾病进展并评估新疗法。