Innovative Methodologies for measuring behavioral vestibular thresholds

测量行为前庭阈值的创新方法

• 批准号: 8467789
• 负责人: Daniel M Merfeld
• 金额: $ 39.25万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-12 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8467789
• 关键词: Accounting; Algorithms; Audiometry; Behavior; Behavior assessment; Behavioral; Behavioral Assay; Biological Assay; Clinic; Clinical; Computers; Cues; Data Analyses; Data Collection; Detection; Development; Diagnosis; Diagnostic Procedure; Discipline; Event; Frequencies; Funding; Goals; Human; Knowledge; Lead; Left; Linear Models; Measurement; Measures; Methodology; Methods; Modality; Modeling; Motion Perception; Nature; Pathway interactions; Patients; Perception; Physiological; Procedures; Process; Psychometrics; Psychophysiology; Publications; Publishing; Reflex action; Reporting; Research; Resources; Sensory; Signal Detection Analysis; Signal Transduction; Stimulus; Symptoms; System; Techniques; Testing; Thalamic structure; Time; Vestibular Function Tests; Visual; base; behavior measurement; clinical Diagnosis; clinical application; experience; human subject; improved; innovation; novel; prototype; research study; response; sensory system; simulation; theories; vestibulo-ocular reflex

DESCRIPTION (provided by applicant): Recent studies have shown that reflexes and perception evoked by vestibular cues can utilize qualitatively different mechanisms; yet there is a paucity of knowledge regarding vestibular perception. This may be why large percentages of vestibular patients report perceptual deficits that are undiagnosed. Regardless of explanation, the underlying causes of many perceptual deficits are not diagnosed. With the exception of the subjective visual vertical test, quantitative clinical tests focus exclusively on reflexive responss. However, the best way to assay undiagnosed motion perception symptoms is via perceptual testing. Therefore, the primary goal for the research proposed herein is to develop new and improved methodologies to measure behavioral thresholds, in general, and vestibular thresholds, in particular. To achieve these goals, we propose theoretic analyses, numerical simulations, and some limited human testing. More specifically, to accomplish the above goals we proposal the following specific aims: Aim 1. Formally and explicitly apply signal detection theory to the measurement of behavioral vestibular thresholds. Aim 2. Develop, test, and verify improved analysis techniques for behavioral thresholds. Aim 3. Develop, apply, and verify automated computer adaptive methodologies for behavioral vestibular threshold data collection.

描述（由申请人提供）：最近的研究表明，前庭线索引起的反射和感知可以利用性质不同的机制；然而，关于前庭知觉的知识却很少。这可能就是为什么很大一部分前庭患者报告有未确诊的知觉缺陷。不管如何解释，许多知觉缺陷的根本原因尚未被诊断出来。除了主观视觉垂直测试之外，定量临床测试仅关注反射反应。然而，检测未诊断的运动知觉症状的最佳方法是通过知觉测试。因此，本文提出的研究的主要目标是开发新的和改进的方法来测量一般行为阈值，特别是前庭阈值。为了实现这些目标，我们提出了理论分析、数值模拟和一些有限的人体测试。更具体地说，为了实现上述目标，我们提出以下具体目标： 目标 1. 正式且明确地将信号检测理论应用于行为前庭阈值的测量。目标 2. 开发、测试和验证改进的行为阈值分析技术。目标 3. 开发、应用和验证用于行为前庭阈值数据收集的自动化计算机自适应方法。