MRI T2 mapping for quantitative assessment of venous oxygen saturation
用于定量评估静脉血氧饱和度的 MRI T2 映射
基本信息
- 批准号:9325034
- 负责人:
- 金额:$ 19.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-08-02 至 2019-02-28
- 项目状态:已结题
- 来源:
- 关键词:AddressAmericasBloodBlood Gas AnalysisBlood flowCalibrationCardiacCardiac Catheterization ProceduresCardiac OutputCardiovascular DiseasesCardiovascular systemCatheterizationCathetersCause of DeathClinicalCongenital Heart DefectsCoronary sinus structureDataDiagnosticDiagnostic ProcedureEquationEstimation TechniquesFamily suidaeGeneric DrugsHealthHeartHeart failureHematocrit procedureHemoglobinHypoxemiaIn VitroIschemiaLimb structureLocationMagnetic ResonanceMagnetic Resonance ImagingMapsMeasurementMeasuresMetabolicMethodologyModelingMorphologic artifactsMyocardialOxygenOxygen saturation measurementPatientsPhysiologic pulsePhysiologicalPopulationPreparationProceduresPulmonary Artery CatheterizationPulmonary HypertensionPulmonary artery structureRelaxationReproducibilityRiskSignal TransductionStatistical sensitivityTechniquesTimeTissuesVenousbasebody systemclinical applicationclinically relevantcohortcongenital heart disorderimprovedin vivoindividual patientmeetingsnovel strategiespreventprognostic valuesuccesstau Proteins
项目摘要
Heart failure, pulmonary hypertension, and congenital heart disease can compromise the capacity of the
cardiovascular system to deliver sufficient oxygen (O2) to meet the varying metabolic demands of the organ
systems. Mixed venous oxygen saturation measured in the main pulmonary artery is an accurate marker of the
systemic delivery of blood and oxygen that provides key diagnostic and prognostic value. However, a true
mixed venous saturation requires catheter access to the main pulmonary artery and may be underutilized as a
diagnostic measure due to the associated level of invasiveness and risk. A non-invasive means to quickly and
accurately measure O2 saturation (O2sat) in the main pulmonary artery, the cardiac chambers, and ideally
anywhere in the body, would not only reduce the need for invasive catheterization procedures, but would also
provide important physiological information that may be otherwise unavailable or unobtainable.
In the blood, the magnetic resonance transverse relaxation time (T2) is related to the oxygen saturation of
hemoglobin, and MR relaxometry has been previously proposed for in vivo estimation of blood O2 saturation;
however, these estimates have relied on an impractical in vitro calibration on each patient, and results have
been corrupted by flow-induced artifacts. A technique previously developed in our lab for rapid, single-shot T2
mapping has been modified to reduce flow artifacts and improve the accuracy of T2 measured in flowing blood.
Together with this modified pulse sequence, we propose an entirely new approach to solving the Luz-Meiboom
(L-M) equation that describes the relationship between T2 and O2sat in blood. We hypothesize that the use of
varied preparation pulse timing along with direct measurement of easily accessible patient specific parameters
will support the application of non-linear parameter estimation techniques to provide an accurate quantitative
assessment of blood O2sat in the heart and deep vessels, even in locations having limited accessibility with
other diagnostic techniques. We propose to optimize and validate this approach to non-invasive blood oximetry
by meeting the following specific aims. Aim 1: We will define appropriate limits for acquisition parameters TE
and 180 in a flow phantom and optimize acquisition parameters using statistical sensitivity analysis. Aim 2: We
will empirically validate O2sat derived from T2 in a porcine model of graded hypoxemia that enables
simultaneous acquisition of T2 and invasive O2sat measurement over a broad range of values. Aim 3: We will
evaluate feasibility in a small cohort of heart failure patients undergoing clinically indicated pulmonary artery
catheterization for mixed venous O2sat measurement.
By addressing the flow sensitivity of the T2 preparation pulse and the inaccuracies introduced by
oversimplification of the model relating T2 to O2sat, we anticipate that the level of accuracy and reproducibility
for this technique will be raised to that required for clinical application in patients with cardiovascular disease.
τ
心力衰竭、肺动脉高压和先天性心脏病会损害心脏的功能
心血管系统提供足够的氧气 (O2) 以满足器官不同的代谢需求
在主肺动脉中测量的混合静脉血氧饱和度是准确的标志。
然而,血液和氧气的全身输送提供了关键的诊断和预后价值。
混合静脉饱和度需要导管进入主肺动脉,并且可能未充分利用作为
由于相关的侵入性和风险水平而采取的非侵入性手段,可以快速而有效地进行诊断。
准确测量主肺动脉、心室中的 O2 饱和度 (O2sat),理想情况下
身体任何地方,不仅可以减少侵入性导管插入手术的需要,而且还可以
提供可能无法获得或无法获得的重要生理信息。
在血液中,磁共振横向弛豫时间(T2)与血液中的氧饱和度有关。
血红蛋白和 MR 松弛测定法先前已被提议用于体内血氧饱和度的估计;
然而,这些估计依赖于对每位患者进行不切实际的体外校准,结果
被流引起的伪影破坏了,这是我们实验室之前开发的快速单次 T2 技术。
映射已被修改,以减少流动伪影并提高流动血液中测量的 T2 的准确性。
结合这种修改后的脉冲序列,我们提出了一种全新的方法来解决 Luz-Meiboom
(L-M) 方程描述了血液中 T2 和 O2sat 之间的关系。
各种准备脉冲定时以及易于访问的患者特定参数的直接测量
将支持非线性参数估计技术的应用,以提供准确的定量
评估心脏和深部血管中的血氧饱和度,即使是在交通不便的地方
我们建议优化和验证这种无创血氧测定方法。
通过满足以下具体目标 1:我们将为采集参数 TE 定义适当的限制。
和 180 在流动模型中,并使用统计灵敏度分析优化采集参数:我们。
将在分级低氧血症的猪模型中凭经验验证源自 T2 的 O2sat,该模型能够
同时采集大范围值的 T2 和侵入式 O2sat 测量值 目标 3:我们将。
评估一小群接受临床指示肺动脉治疗的心力衰竭患者的可行性
插管进行混合静脉 O2sat 测量。
通过解决 T2 准备脉冲的流量敏感性以及由
T2 与 O2sat 相关的模型过于简化,我们预计准确性和再现性水平
因为这项技术将提升到心血管疾病患者临床应用所需的水平。
τ
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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