Parallel Tectothalamic Pathways
平行的顶盖丘脑通路
基本信息
- 批准号:9129777
- 负责人:
- 金额:$ 43.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-09-02 至 2019-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAnimalsBackButyric AcidsCell NucleusCellsCodeDetectionDiseaseDorsalDyslexiaElectron MicroscopyElectronsElectrophysiology (science)HealthHomologous GeneIn VitroInvestigationLateralLateral Geniculate BodyLateral posterior nucleus of thalamusLiteratureMicroscopicMotionMotion PerceptionMovementMusNeuronsOutputPathway interactionsPerceptionPopulationProcessPropertyPulvinar structureReactionResearchRodentSchizophreniaSignal TransductionSiteStimulusStreamStructureSynapsesTechniquesTectum MesencephaliThalamic structureVisionVisualVisual MotionVisual system structureWhole-Cell Recordingsarea striatabasebrain circuitrycell typedetectorextrastriateextrastriate visual cortexinsightmagnocellularmotion sensitivitynoveloptogeneticsparvocellularreceptive fieldresearch studyresponsesegregationsuperior colliculus Corpora quadrigeminavisual neurosciencevisual stimulus
项目摘要
DESCRIPTION (provided by applicant): The superficial layers of the superior colliculus (SC) contain two cell types that both respond to the movement of visual stimuli, but are morphologically and functionally distinct. A projection from the SC to the lateral posterior nucleus (LPN) originates from wide-field vertical (WFV) cells, while a projection from the SC to the dorsal lateral geniculate nucleus (dLGN) originates from narrow-field vertical (NFV) cells. WFV cells have been described as motion detectors based on their responses to small stimuli moving in any direction within a very large receptive field. In contrast, NFV cells may be specialized to code more detailed motion parameters based on their small receptive fields and strong direction selectivity. The parallel WFV and NFV pathways remain segregated in that the tectorecipient dLGN and LPN project differentially to the striate and extrastriate cortex. However, little is known regarding the interaction between the SC, the tectorecipient thalamus, and the cortex. We propose to analyze the circuits that connect these structures in mice by using novel combinations of optogenetics, in vitro whole cell recordings from neuronal populations identified by retrograde tracing techniques, as well as quantitative electron microscopic investigation of synaptic connections. The Aim 1 experiments will use in vitro whole cell recording from identified cortical cell populations and optogenetic activation of terminals tht originate from the tectorecipient dLGN or LPN to determine which cell types are directly innervated and to characterize the electrophysiological properties of these synapses. Electron microscopy will quantify ultrastructural features of these synapses. The Aim 2 experiments will use in vitro whole cell recordings from NFV and WFV cells and optogenetic activation of corticotectal terminals to determine whether these cells receive direct or indirect input from V1 or the lateral extrastriate cortex, and to characterize the electrophysiological properties of thes connections. Electron microscopy will quantify ultrastructural features of corticotectal synapses and the distribution inputs to NFV and WFV cells that do and do not contain gamma amino butyric acid (GABA). As comparisons of parallel geniculocortical pathways have led to insights regarding cortical processing streams, a comparison of WFV and NFV tecto-thalamo-cortical pathways will help us to understand how different aspects of visual motion are utilized by the visual system. In addition, our circuit analysis can help reveal whether corticotectal pathways are organized to enhance segregation, or synthesis, of motion signals
描述(由申请人提供):上丘(SC)的浅层包含两种细胞类型,它们都对视觉刺激的运动做出反应,但在形态和功能上不同。从 SC 到外侧后核 (LPN) 的投影源自宽视野垂直 (WFV) 细胞,而从 SC 到背外侧膝状核 (dLGN) 的投影源自窄视野垂直 (NFV) 细胞。 WFV 细胞被描述为运动探测器,基于它们对在非常大的感受野内向任何方向移动的小刺激的反应。相比之下,NFV 单元可以根据其较小的感受野和较强的方向选择性来专门编码更详细的运动参数。并行的 WFV 和 NFV 通路仍然是分离的,因为受盖 dLGN 和 LPN 不同地投射到纹状体和纹状体外皮层。然而,人们对 SC、受盖丘脑和皮质之间的相互作用知之甚少。我们建议通过使用光遗传学、逆行追踪技术鉴定的神经元群的体外全细胞记录以及突触连接的定量电子显微镜研究的新组合来分析连接小鼠中这些结构的电路。 Aim 1 实验将使用来自已识别的皮层细胞群的体外全细胞记录和源自 dLGN 或 LPN 的末端的光遗传学激活来确定哪些细胞类型受到直接神经支配并表征这些突触的电生理特性。电子显微镜将量化这些突触的超微结构特征。 Aim 2 实验将使用 NFV 和 WFV 细胞的体外全细胞记录以及皮质顶盖末端的光遗传学激活来确定这些细胞是否接收来自 V1 或外侧纹状体皮质的直接或间接输入,并表征这些连接的电生理特性。电子显微镜将量化皮质皮层突触的超微结构特征以及含有和不含伽马氨基丁酸 (GABA) 的 NFV 和 WFV 细胞的分布输入。由于平行膝皮质通路的比较可以深入了解皮质处理流,因此 WFV 和 NFV 顶盖-丘脑-皮质通路的比较将帮助我们了解视觉系统如何利用视觉运动的不同方面。此外,我们的电路分析可以帮助揭示皮质皮层通路是否被组织起来以增强运动信号的分离或合成
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MARTHA E BICKFORD其他文献
MARTHA E BICKFORD的其他文献
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