Biomedical Informatics and Statistics Core

生物医学信息学和统计核心

• 批准号: 9404837
• 负责人: Lei Liu
• 金额: $ 17.04万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9404837
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Adult; Africa; American; Area; Biological Markers; Biometry; Cervical; Clinic; Clinical; Clinical Data; Clinical Research; Collaborations; Communicable Diseases; Communication; Communities; Consultations; Country; Coupled; Data; Data Collection; Data Quality; Databases; Development Plans; Diagnostic; Educational Curriculum; Emergency Situation; Epigenetic Process; Foundations; Funding; Future; Genetic Research; Genomics; Goals; Grant; HIV; Health; Healthcare; Hepatitis B; Hepatitis C; Human Papillomavirus; Income; Informatics; Inpatients; Institutes; Institution; International; International AIDS; Leadership; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Medical; Medical Education; Medical Research; Mentors; Modernization; Molecular Epidemiology; Needs Assessment; Nigeria; Nigerian; Outcome; Outpatients; Pathology; Patients; Positioning Attribute; Prevention; Prevention Research; Primary carcinoma of the liver cells; Protocols documentation; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Proposals; Research Training; Resources; Sampling; Services; Statistical Data Interpretation; Surveys; System; Time; Training Activity; Training Programs; Training Support; United States National Institutes of Health; Universities; Viral hepatitis; Virus; Virus Diseases; anticancer research; biomedical informatics; cancer care; cancer genetics; career; community organizations; data integration; data management; data sharing; disorder prevention; electronic data; epidemiology study; epigenomics; global health; improved; infrastructure development; inter-institutional; interdisciplinary approach; interest; international center; medical schools; neoplasm registry; operation; programs; quality assurance; repository; response; statistics; AIDS prevention; Acquired Immunodeficiency Syndrome; Adult; Africa; American; Area; Biological Markers; Biometry; Cervical; Clinic; Clinical; Clinical Data; Clinical Research; Collaborations; Communicable Diseases; Communication; Communities; Consultations; Country; Coupled; Data; Data Collection; Data Quality; Databases; Development Plans; Diagnostic; Educational Curriculum; Emergency Situation; Epigenetic Process; Foundations; Funding; Future; Genetic Research; Genomics; Goals; Grant; HIV; Health; Healthcare; Hepatitis B; Hepatitis C; Human Papillomavirus; Income; Informatics; Inpatients; Institutes; Institution; International; International AIDS; Leadership; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Medical; Medical Education; Medical Research; Mentors; Modernization; Molecular Epidemiology; Needs Assessment; Nigeria; Nigerian; Outcome; Outpatients; Pathology; Patients; Positioning Attribute; Prevention; Prevention Research; Primary carcinoma of the liver cells; Protocols documentation; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Proposals; Research Training; Resources; Sampling; Services; Statistical Data Interpretation; Surveys; System; Time; Training Activity; Training Programs; Training Support; United States National Institutes of Health; Universities; Viral hepatitis; Virus; Virus Diseases; anticancer research; biomedical informatics; cancer care; cancer genetics; career; community organizations; data integration; data management; data sharing; disorder prevention; electronic data; epidemiology study; epigenomics; global health; improved; infrastructure development; inter-institutional; interdisciplinary approach; interest; international center; medical schools; neoplasm registry; operation; programs; quality assurance; repository; response; statistics

Project Summary We propose to establish a Consortium to study “Epigenomic Biomarkers of HIV-Associated Cancers in Nigeria.” Our research focus and core services development plan has been prioritized by our Nigerian partners at University of Jos (UniJos), Plateau State, Nigeria located in the center of the country and University of Lagos (UniLag), Lagos State in the densely populated southwest. Our focus on the epigenetics of HIV-associated hepatocellular carcinoma (HCC) and cervical cancer is justified by our extensive collaborative research history in viral diseases including HIV, human papilloma virus, hepatitis B and C viruses. Northwestern University and Mayo Medical School will serve as the high-income American partner institutions which is justified by the long history of research and research training collaboration with the Nigerian institutions coupled with its expertise in global health and ample complementary resources. The specific aims of the Biomedical Informatics and Statistics Core (BISC) are: 1. enhance the existing clinical systems (HIV clinic electronic databases and cancer registries) to develop high-quality electronic clinical data collection on HIV-associated cancers across outpatient and inpatient systems at UniJos and UniLag, 2. develop a collaborative biomedical informatics and statistics team focused on providing core services for HIV-associated cancer genetics research in Nigeria, and 3. provide oversight and support for the informatics and statistical needs of Projects 1 (HCC) and 2 (cervical) proposed under this U54. Under this BISC, electronic data collection and management capabilities will be coordinated into a single Cancer Research Informatics System (CRIS). CRIS will include the following aspects: (1) data collection, (2) survey distribution for needs assessments and community engagement, (3) communication and BISC coordination, (4) financial/grants management, (5) data management and quality assurance, (6) linkage of clinical data and research biospecimen repository samples, (7) tracking/compliance of research proposals, and (8) tracking and outcomes of BISC services. The following BISC services will also be developed: centralized data integration and management, computational facilities and biostatistical consultations. The overall goal of the BISC will be to support and facilitate research proposed in Projects 1 (HCC) and 2 (cervical), provide facilities for training activities under the Career Enhancement Core (CEC), coordination of research services with the Pathology and Genomics Core (PGC), build infrastructure and research management with the Administrative Core (AC).

项目摘要 我们建议建立一个联盟，以研究“尼日利亚与HIV相关癌症的表观基因组生物标志物”。 我们的研究重点和核心服务开发计划已由我们的尼日利亚合作伙伴优先考虑 乔斯大学（UNIJOS），尼日利亚高原州，位于该国中心和拉各斯大学 （unilag），拉各斯州位于人口稠密的西南。我们关注与HIV相关的表观遗传学 我们广泛的合作研究历史证明了肝细胞癌（HCC）和宫颈癌是合理的 在病毒疾病中，包括HIV，人乳头瘤病毒，乙型肝炎和C病毒。西北大学和 梅奥医学院将担任高收入美国合作伙伴机构 研究与研究培训的历史与尼日利亚机构合作，并在其方面的专业知识 全球健康和充足的完整资源。生物医学信息学和 统计核心（BISC）为：1。增强现有的临床系统（HIV临床电子数据库和癌症 注册表）在跨门诊的HIV相关癌症上开发高质量的电子临床数据收集 以及Unijos和Unilag的住院系统，2。开发协作生物医学信息和统计数据 团队专注于为尼日利亚与HIV相关的癌症遗传学研究提供核心服务，并提供3。 对项目1（HCC）和2（宫颈）提议的信息和统计需求的监督和支持 在这个U54下。在此BISC下，电子数据收集和管理功能将得到协调 进入单个癌症研究信息学系统（CRIS）。 CRIS将包括以下方面：（1）数据 收集，（2）针对需求评估和社区参与的调查分配，（3）沟通和 BISC协调，（4）财务/赠款管理，（5）数据管理和质量保证，（6） 临床数据和研究生物测量存储库样本，（7）研究建议的跟踪/合规性 （8）跟踪和成果。还将开发以下BISC服务：集中式 数据集成和管理，计算设施和生物统计咨询。总体目标 BISC将支持和促进项目1（HCC）和2（宫颈）提议的研究，提供设施 在职业增强核心（CEC）下的培训活动中，研究服务与 病理和基因组学核心（PGC），通过行政管理建立基础架构和研究管理 核心（AC）。