The Neural Basis of Apathy in Frontotemporal Degeneration: A Longitudinal Study

额颞叶退化中冷漠的神经基础：一项纵向研究

• 批准号: 8647992
• 负责人: Lauren M Massimo
• 金额: $ 4.98万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-01 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8647992
• 关键词: Activities of Daily Living; Advanced Practice Nurse; Affect; Alleles; Anatomic structures; Anisotropy; Anterior; Apolipoprotein E; Atrophic; Bathing; Behavior; Behavioral; Biological; Biological Factors; Brain; Brain Pathology; Brain region; Caregiver Burden; Caregivers; Caring; Clinical; Cognitive; Data; Development; Diffusion Magnetic Resonance Imaging; Disease; Education; Effectiveness of Interventions; Environmental Risk Factor; Family Caregiver; Fellowship; Financial compensation; Frontotemporal Dementia; Functional disorder; Funding; Genetic; Genetic Databases; Geriatric Nursing; Goals; Grant; Haplotypes; Health; Imaging Techniques; Impairment; Individual; Individual National Research Service Award; Interdisciplinary Study; Intervention; Investigation; Knowledge; Laboratory Study; Lead; Leisure Activities; Longitudinal Studies; Measures; Mediating; Methods; Morbidity - disease rate; Motivation; National Institute of Nursing Research; National Research Service Awards; Natural History; Neurodegenerative Disorders; Neurological Nursing; Neurologist; Nurses; Nursing Research; Occupational; Occupations; Outcome; Participant; Patients; Performance at work; Persons; Play; Predoctoral Individual National Research Service Award; Prefrontal Cortex; Research; Research Personnel; Research Priority; Research Proposals; Research Training; Resources; Risk; Role; Scientist; Sterile coverings; Strategic Planning; Syndrome; Testing; Time; Training; Variant; Work; base; brain behavior; career; cingulate cortex; cognitive reserve; cost; design; early onset; effective intervention; experience; gray matter; improved; innovation; insight; longitudinal analysis; longitudinal course; mortality; neuroimaging; neuropsychiatry; neuropsychological; post-doctoral training; programs; public health relevance; relating to nervous system; skills; tau Proteins; theories; therapy development; white matter; white matter change

Project Summary The purpose of this individual National Research Service Award (NRSA) is to provide postdoctoral research training for a neuroscience nurse to become an independent investigator focusing on the behavioral and biological mechanisms that contribute to neuropsychiatric syndromes such as apathy in patients with neurodegenerative disease (ND). In addition to coursework and the acquisition of new research skills, I propose to focus this NRSA on impairments of goal-directed behavior (GDB) that are very common but understudied in ND. The syndrome of apathy, defined as a reduction in self-generated or voluntary behavior,1 has profound consequences for morbidity and mortality in the patient and for family caregiver burden. Treatments for apathy are hindered because of our poor understanding of the mechanisms underlying this behavior. In my cross-sectional dissertation data (funded by NINR F31NR013306), I identified three subtypes of apathy in patients with behavioral variant Frontotemporal Degeneration (bvFTD): difficulty with initiation, planning or motivation. Each subtype is related to disease in distinct frontal regions. Based on preliminary longitudinal data, I will collect additional data to test the hypothesis that subtypes of apathy will worsen over time, and that decline will be restricted to the subtype of initial impairment. I will also extend my research program to investigate how biologic and environmental factors contribute to worsening in apathy. I have had more than 8 years of experience as an Advanced Practice Nurse and Research Nurse Coordinator in a nationally ranked laboratory that studies the neural basis for behavior in ND. I have direct access to research participants as well as a large database of genetic and neuroimaging data that I will incorporate into my analyses. My research training will be guided by two internationally known scientists, Dr. Ann Kolanowski, a well-known gerontological nurse expert and leader, and Dr. Murray Grossman, a highly acclaimed cognitive neurologist and experienced scientist. The interdisciplinary training during the performance of this work will serve as an essential component in attaining my career goal to become an independent neuroscience nurse researcher. The long-term impact of this research training will be profound for patients with ND, their caregivers, and families. Knowledge of the natural history of apathy is essential in the development of interventions for subtypes of apathy. Consistent with the National Institute of Nursing Research (NINR) priorities, this innovative work will lead to a better understanding of these brain behavior relationships and with this new knowledge, tailored interventions will be designed to reduce apathy and the poor health outcomes that are associated with this devastating condition.

项目概要 该国家研究服务奖（NRSA）的目的是提供博士后研究 对神经科学护士进行培训，使其成为专注于行为和行为的独立调查员 导致神经精神综合征的生物学机制，例如患者的冷漠 神经退行性疾病（ND）。除了课程作业和获得新的研究技能之外，我 建议将此 NRSA 重点关注目标导向行为 (GDB) 的损伤，这种损伤非常常见，但 在 ND 实习。冷漠综合症，定义为自发或自愿行为的减少，1 对患者的发病率和死亡率以及家庭护理人员的负担具有深远的影响。 由于我们对冷漠背后的机制了解甚少，冷漠的治疗受到阻碍 行为。在我的横断面论文数据（由 NINR F31NR013306 资助）中，我确定了三种亚型 行为变异型额颞叶变性（bvFTD）患者的冷漠：启动困难， 计划或动机。每种亚型都与不同额叶区域的疾病相关。 根据初步的纵向数据，我将收集额外的数据来检验以下假设： 冷漠会随着时间的推移而恶化，并且这种下降将仅限于初始损伤的亚型。我也会 扩展我的研究计划，以调查生物和环境因素如何导致病情恶化 冷漠。我拥有超过 8 年的高级实践护士和研究护士经验 国家级实验室的协调员，该实验室研究 ND 行为的神经基础。我有直接的 访问研究参与者以及我将收集的遗传和神经影像数据的大型数据库 纳入我的分析。我的研究培训将由两位国际知名科学家指导，他们是 Dr. 安·科拉诺夫斯基 (Ann Kolanowski) 是一位著名的老年护理专家和领导者，默里·格罗斯曼 (Murray Grossman) 博士是一位杰出的老年护理专家。 著名的认知神经学家和经验丰富的科学家。 执行这项工作期间的跨学科培训将作为一个重要组成部分 实现我的职业目标，成为一名独立的神经科学护士研究员。的长期影响 这项研究培训对于 ND 患者、他们的护理人员和家人来说意义深远。的知识 冷漠的自然史对于制定针对冷漠亚型的干预措施至关重要。持续的 根据国家护理研究所 (NINR) 的优先事项，这项创新工作将带来更好的结果 了解这些大脑行为关系，并利用这些新知识，量身定制的干预措施将 旨在减少与这种破坏性状况相关的冷漠和不良健康结果。