Translational, multimodality correlation between human and rabbit saccular aneurysms

人和兔囊状动脉瘤之间的转化、多模态相关性

基本信息

批准号：
8995704
负责人：
DAVID F KALLMES
金额：
$ 18.88万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-01 至 2018-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8995704
关键词：
3-Dimensional Adult Aftercare Age-Years Aneurysm Animal Model Animals Arteries Autopsy Berry Aneurysm Biological Biology Blood Circulation Blood Pressure Brain Cell Death Cell physiology Cells Cerebral Aneurysm Cessation of life Clinic Clinical Clip Collagen Collagen Fiber Computer Simulation Data Development Devices Diagnosis Elastases Elastin Endothelium Environment Equilibrium Event Evolution Extracellular Matrix Frequencies Functional disorder Funding Germ Cells Goals Growth Health Histologic Histology Human Hyperplasia Interdisciplinary Study Intracranial Aneurysm Liquid substance MRI Scans Mechanics Methods Microscopy Modeling Molecular Molecular Biology Morbidity - disease rate Neurologic Oryctolagus cuniculus Pathology Patient Care Patient risk Patients Pattern Pharmacologic Substance Population Predictive Value Process Research Research Proposals Risk Risk Assessment Role Rupture Ruptured Aneurysm Smooth Muscle Myocytes Spontaneous Rupture Staging Stratification Stress Structure Surrogate Markers Techniques Testing Text Textiles Thrombus Time Tissues Translating Translational Research Treatment outcome Uncertainty United States Vascular Smooth Muscle Work X-Ray Computed Tomography base brain surgery hemodynamics human tissue implantation improved improved outcome innovation minimally invasive multimodality novel programs shear stress success three dimensional structure treatment strategy

项目摘要

DESCRIPTION (provided by applicant): The long term objective of this research program is to improve the care of patients harboring unruptured, intracranial aneurysms. These aneurysms, present in approximately 2% of the population and being diagnosed with increasing frequency because of widespread use of MRI and CT scanning, may undergo spontaneous rupture with devastating consequences. Once discovered, however, the decision to treat must balance the risk of spontaneous rupture against the treatment risk. The annual risk of aneurysm rupture is low, but there are relatively few high quality studies documenting precise rates of rupture. Furthermore, even with the most advanced treatment techniques, one in twenty patients will suffer from neurologic morbidity from the therapy itself. Unfortunately, clinical and autopsy data that might clarify these uncertainties remain elusive. In an attempt to improve outcomes in these patients, numerous groups are exploring the predictive value of surrogate markers of rupture risk and treatment outcome. These approaches include detailed analysis of geometric and other features to be used in computational modeling for prediction of rupture risk as well as the development of innovative, minimally invasive therapies. Animal models of saccular aneurysms serve as bridge between these research hypotheses and the clinic, translating new ideas to clinical implementation. The proposed work will first confirm that the animal model accurately mimics the pathology, biology, and mechanical structure of actual human aneurysm tissue. This project will benefit patients suffering from intracranial aneurysms, both before and after treatment, with the long term goal of diminishing or eradicating the risk of devastating aneurysm rupture.

描述（由申请人提供）：该研究计划的长期目标是改善对患有未破裂颅内动脉瘤的患者的护理，这些动脉瘤存在于大约 2% 的人口中，并且由于广泛使用而被诊断的频率不断增加。然而，MRI 和 CT 扫描可能会导致自发性破裂，从而造成灾难性后果，但治疗决策必须权衡自发性破裂的风险和每年的治疗风险。动脉瘤破裂率较低，但记录精确破裂率的高质量研究相对较少。此外，即使采用最先进的治疗技术，也有十分之一的患者会因治疗本身而罹患神经系统疾病。可能会澄清这些不确定性仍然难以捉摸，为了改善这些患者的结果，许多小组正在探索破裂风险和治疗结果的替代标志物的预测价值，这些方法包括对几何和其他特征的详细分析。用于预测破裂风险的计算模型以及囊状动脉瘤动物模型的开发是这些研究假设和临床之间的桥梁，将新想法转化为临床实施。该动物模型准确地模拟了实际人类动脉瘤组织的病理学、生物学和机械结构，该项目将使患有颅内动脉瘤的患者在治疗前和治疗后受益，其长期目标是减少动脉瘤。或消除毁灭性动脉瘤破裂的风险。