Training Grant in Environmental Toxicology

环境毒理学培训补助金

• 批准号: 9103125
• 负责人: JOHN M ESSIGMANN
• 金额: $ 42.43万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9103125
• 关键词: Grant; Training; environmental toxicology

 DESCRIPTION (provided by applicant) The goal of this training program in environmental toxicology is to produce scientists professionally qualified to make original contributions to improved understanding of the impacts of environmental agents, especially hazardous chemicals, on human health. Trainees pick projects from the following areas: (1) analysis of genome-, proteome- and glycome-level responses to toxins and toxicants; (2) characterization of mutagenic responses to carcinogens as expressed hierarchically at the genome, cell, tissue, organism and population levels of organization; (3) construction of novel animal models for determining the effects of exposure of mammals to environmental agents; (4) investigation of intra-cellular kinase-mediated signaling cascades triggered in response to toxic agents, and during neoplastic transformation and endometriosis; (5) characterization of the chemistry underlying the reaction of toxins and toxicants with cellular macromolecules and other targets; (6) mechanistic assessment of the contribution of specific DNA adducts to genetic disease, and identification of the cellular defenses (e.g., DNA repair strategies) that protect against DNA damage; (7) engineering-based design of novel model systems for evaluating responses to toxic agents; (8) design of novel sensing systems to track pollutants; and, (9) measurement of pollution distribution in the environment. A central theme that has developed during the past five years, which links all nineteen research groups, is the interplay between environmental chemicals and infectious agents in human disease. Highlights of the program are a well-structured and constantly updated academic program taken by pre-doctoral students, a postdoctoral mentoring program, numerous toxicology-focused seminar programs and a large emphasis on research collaboration. More than 400 students apply for the pre-doctoral program annually, allowing for good program selectivity. This program supports seven pre-doctoral and six postdoctoral trainees. It has supported 100 pre-doctoral and 80 postdoctoral trainees since its inception in 1975. During that same time period, 251 Ph.D. or Sc.D. degrees have been awarded to all students in the MIT toxicology program (trainees plus non-trainees). Of the pre-doctoral and postdoctoral graduates over the past 10 years, 7 out of 20 (35%) are in academic or postdoctoral positions and 13 of 20 (65%) are in industry. Of the 251 degrees awarded, 37 recipients have become professors and 6 are in other forms of teaching.

 描述（由申请人提供） 该环境毒理学培训计划的目的是创造专业资格的科学家，以提高对环境药物（尤其是危险化学物质）对人类健康的影响的理解的原始贡献。受训人员从以下领域挑选项目：（1）分析基因组，蛋白质组和Glyce水平对毒素和毒物的反应； （2）在基因组，细胞，组织，组织，组织和人口水平的基因组，细胞，组织，组织和人口水平上，对致癌物的诱变反应的表征； （3）建造新型动物模型，以确定哺乳动物暴露于环境药物的影响； （4）研究对有毒药物以及肿瘤转化和子宫内膜异位时触发的细胞内激酶介导的信号传导级联反应； （5）表征毒素和毒物与细胞大分子和其他靶标的反应的化学反应； （6）对特定DNA加合物对遗传疾病的贡献的机理评估，并鉴定了防止DNA损伤的细胞防御措施（例如DNA修复策略）； （7）基于工程的新型模型系统设计，用于评估对有毒剂的反应； （8）设计新型传感系统以跟踪污染物； （9）环境中污染分布的测量。在过去五年中，与所有十九个研究小组联系起来的一个中心主题是环境化学物质与人类疾病中传染剂之间的相互作用。该计划的亮点是一项结构化良好且不断更新的学术课程，该计划由博士前学生，博士后心理计划，众多以毒理学为中心的半程编程以及大型研究合作紧急情况。每年有400多名学生每年申请博士前计划，从而提高了良好的计划选择性。 该计划支持七名博士后和六名博士后学员。自1975年成立以来，它已支持100名博士后和80名博士后学员。在同一时期，251 Ph.D.或SC.D.在MIT毒理学计划（Traines Plus Non-Traines）中，所有学生都授予了学位。在过去的10年中，博士前和博士后毕业生中有7名（35％）处于学术或博士后职位，而20名（65％）中有13名（65％）在行业中。在授予的251度中，有37位接受者已成为教授，而6位则以其他形式的教学形式。