Exploring the Effects of Strength Training on Depressive Symptoms and Cardiovascular Risk in Black Men

探索力量训练对黑人抑郁症状和心血管风险的影响

基本信息

批准号：
9182593
负责人：
Andrew M Busch
金额：
$ 18.86万
依托单位：
COLUMBIA UNIVERSITY TEACHERS COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-26 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9182593
关键词：
Accounting Acute Address Aerobic Affect African American American Heart Association Blinded Blood Pressure Body Composition Cardiovascular Diseases Cardiovascular system Cause of Death Cessation of life Clinical Clinical Trials Cognitive Data Depressed mood Depressive disorder Development Diagnosis Exercise Female Funding Future Health Health behavior Heart Diseases Individual Intervention Interview Interviewer Link Literature Masculine Measures Mediator of activation protein Mental Depression Methods Minority Moods Participant Patient Self-Report Pharmaceutical Preparations Pharmacological Treatment Physical Exercise Physiological Preparation Procedures Psychiatric therapeutic procedure Psychotherapy Public Health Randomized Randomized Clinical Trials Randomized Controlled Trials Recruitment Activity Reporting Research Risk Factors Risk Reduction Sampling Self Concept Severities Site Sleep Smoker Stroke Surveys Techniques Testing Training Programs Waist-Hip Ratio Weight Weight Lifting abstracting base blind blood lipid burden of illness cardiovascular disorder risk cardiovascular health cardiovascular risk factor combat depressive symptoms efficacy testing exercise program experience follow-up health disparity improved inflammatory marker innovation male health meetings men mortality preference primary outcome programs prospective psychologic secondary outcome sedentary self esteem social social stigma strength training

项目摘要

Project Summary/Abstract Depression is severely undertreated in Black men. Significant reasons for this include that traditional psychiatric treatments (i.e., psychotherapy and medication) are less acceptable to Black men, and that Black men report significant stigma regarding seeking these treatments. Depression also has major health consequences, including increased occurrence and worsening of cardiovascular disease (CVD), and even CVD mortality. We propose to address gaps in the literature and advance the field of minority men’s health by conducting the first randomized controlled trial testing the effects of strength training (i.e., weight lifting) on depression and cardiovascular health in a sample of depressed Black men. A total of 50 self-identifying Black men who meet a clinical level of depression will be randomized into a 12-week strength training (ST) program or a 12-week contact control. Both groups will meet on-site twice per week during the 12-week program, and follow-up assessments will occur at the end of the 12-weeks and at a 3-month follow-up. Blind to condition research staff will conduct assessments at baseline, end-of-treatment, and 3-month follow-up. Qualitative interviews will be conducted immediately after the 3-month follow-up to gather input on participants’ experiences and preferences. The primary outcome will be depression severity (measured by interview). Secondary outcomes will be inflammatory markers and CVD indicators (e.g., blood lipids, blood pressure, waist-to-hip ratio, body composition). The overall aim of this exploratory (R21) study is to establish the feasibility, acceptability, and initial efficacy of strength training as an intervention for depression in Black men. Specific aims are (1) To assess the feasibility and acceptability of recruitment, retention, assessment, and intervention procedures among depressed Black men, (2) To obtain preliminary evidence of efficacy in preparation for a future R01-supported randomized clinical trial, and (3) To explore potential mediators of the effect of ST on depression, including physiological (i.e., sleep quality) and psychological (i.e., self-esteem, acute changes in affect, enjoyment of exercise, physical self-concept) variables. The proposed research will lay the groundwork for a larger efficacy study of ST for Black men that will be fully powered to detect changes in both depression and CVD risk over long-term follow-up. Such a trial would be an initial step to combating major health disparities regarding CVD and treatment for depression among Black men.

项目概要/摘要黑人男性的抑郁症治疗严重不足，其重要原因包括传统观念。黑人男性不太接受精神科治疗（即心理治疗和药物治疗），并且黑人男性表示，寻求这些治疗方法会带来严重的耻辱。抑郁症也对健康有重大影响。后果，包括心血管疾病（CVD）的发生率增加和恶化，甚至我们建议通过以下方式解决文献空白并推进少数族裔男性健康领域的发展。进行第一个随机对照试验，测试力量训练（即举重）对身体的影响抑郁症黑人男性样本中的抑郁症和心血管健康共有 50 名自我认同的黑人。达到临床抑郁程度的男性将被随机分配参加为期 12 周的力量训练 (ST) 计划或为期 12 周的接触控制。在为期 12 周的计划中，两个小组每周将在现场会面两次，并且后续评估将在 12 周结束时和 3 个月的盲态随访中进行。研究人员将在基线、治疗结束和 3 个月随访时进行评估。 3个月的随访后将立即进行访谈，以收集参与者的意见主要结果是抑郁症的严重程度（通过访谈衡量）。次要结果是炎症标志物和 CVD 指标（例如血脂、血压、这项探索性 (R21) 研究的总体目标是建立力量训练作为黑人男性抑郁症干预措施的可行性、可接受性和初步疗效。具体目标是 (1) 评估招聘、保留、评估和培训的可行性和可接受性抑郁黑人男性的干预程序，(2) 获得初步疗效证据为未来 R01 支持的随机临床试验做准备，以及 (3) 探索潜在的介质 ST 对抑郁症的影响，包括生理（即睡眠质量）和心理（即自尊、情感、运动享受、身体自我概念）变量的急剧变化。为黑人男性进行更大规模的 ST 功效研究奠定基础，该研究将完全有能力检测变化这样的试验将是对抗抑郁症和心血管疾病风险的第一步。黑人男性在心血管疾病和抑郁症治疗方面的主要健康差异。