Interventional PhotoAcoustic Surgical System (i-PASS)

介入光声手术系统 (i-PASS)

• 批准号: 8509922
• 负责人: Emad M Boctor
• 金额: $ 23.6万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8509922
• 关键词: Ablation; Acoustics; Address; Anatomy; Biopsy; Brachytherapy; Calibration; Catheters; Computers; Data; Devices; Electromagnetics; Environment; Equipment; Excision; Family suidae; Feedback; Image; Imagery; Imaging Techniques; Intervention; Ionizing radiation; Kidney Neoplasms; Laparoscopic Surgical Procedures; Lasers; Light; Lighting; Liver neoplasms; Magnetic Resonance Imaging; Metals; Methods; Modeling; Monitor; Needle biopsy procedure; Needles; Operative Surgical Procedures; Optics; Organ; Patients; Physiologic pulse; Pilot Projects; Positioning Attribute; Procedures; Process; Radiofrequency Interstitial Ablation; Relative (related person); Robotics; Signal Transduction; Solid; Spottings; Sterility; Surface; Surgeon; System; Techniques; Technology; Time; Tissues; Ultrasonography; Vendor; Vision; Work; base; clinical application; design; experience; image processing; imaging modality; imaging probe; improved; in vivo; innovation; interest; interstitial; minimally invasive; next generation; novel; photoacoustic imaging; public health relevance; sensor; sound; tool; tumor

DESCRIPTION (provided by applicant): This project will develop novel photoacoustic ultrasound imaging techniques to enable accurate, reliable, and efficient fusion of intraoperative ultrasound (IOUS) images with preoperative images, real time video, and other data to assist surgeons in minimally invasive surgery and other interventional procedures. Ultrasound provides many advantages for intraoperative use, and interest in using IOUS in both open and laparoscopic surgery, in providing guidance for biopsies, tumor ablation, brachytherapy, and robotic surgery is growing. One significant factor limiting the use of IOUS is the necessity for the surgeon to relate the information in the ultrasound images to preoperative information such as CT or MRI images and to what he or she is seeing in a laparoscopic video monitor or in direct visualization. Computer-based information fusion and visualization systems have significant potential to overcome this limitation, provided that they can 1) reliably register IOUS images to the surgical scene as observed, e.g., by laparoscopic video; 2) continuously register IOUS and video to preoperative data; and 3) track surgical tools in IOUS images. Current systems typically relying on optical or electromagnetic (EM) navigational trackers have several limitations, including 1) system complexity; 2) accuracy limitations; 3) line-of-sight restrictionsor the presence of extra wires in the surgical field. Our specific aims for this R21 feasibility projct are as follows: Aim 1: Real-time fusion of IOUS and video images: Develop and evaluate innovative photoacoustic methods for real-time, continuous registration of intraoperative US to video camera coordinate systems. Aim 2: Real-time tracking of registered preoperative data: Demonstrate and evaluate real-time, continuous tracking and display of registered preoperative models in IOUS and video camera coordinates. Aim 3: Real-time identification and tracking of interstitial tools in IOUS: Develop illumination and processing methods for generating PA signals on interstitial tools. Demonstrate and evaluate the use of these methods for locating the tiny tines of a typical probe used in RF ablation of tumors in solid organs. Our basic hypothesis is that many of these limitations can be overcome by the novel application of intraoperative photoacoustic (PA) imaging methods to permit direct, real-time localization of fiducial points in ultrasound images. In PA imaging, short pulses of laser light are converted into acoustic signals that can be detected in ultrasound images. If multiple laser spots are projected onto an organ surface, they may be located both in video and in ultrasound, thus permitting direct registration of IOUS-to-camera coordinates. Similarly, PA imaging may be used to locate small, embedded markers inside tissue to permit real-time tracking of registered preoperative images and models relative to IOUS. And it may be used to locate points on interstitial surgical tools and probes, thus permitting direct registration and tracking relative to IOUS. We will evaluate the technology developed in artificial & ex vivo phantoms and in a small in vivo pilot study.

描述（由申请人提供）：该项目将开发新型光声超声成像技术，以实现术中超声（IOUS）图像与术前图像、实时视频和其他数据的准确、可靠和高效融合，以协助外科医生进行微创手术和其他介入程序。超声为术中使用提供了许多优势，并且人们对在开腹手术和腹腔镜手术中使用 IOUS 以及为活检、肿瘤消融、近距离放射治疗和机器人手术提供指导的兴趣日益增长。 限制 IOUS 使用的一个重要因素是外科医生必须将超声图像中的信息与 CT 或 MRI 图像等术前信息以及他或她在腹腔镜视频监视器或直接可视化中看到的内容相关联。基于计算机的信息融合和可视化系统具有克服这一限制的巨大潜力，只要它们能够 1) 可靠地注册 IOUS 观察到的手术场景图像，例如通过腹腔镜视频； 2) 不断将IOUS和视频注册到术前数据中； 3) 在 IOUS 图像中跟踪手术工具。当前通常依赖光学或电磁 (EM) 导航跟踪器的系统有几个局限性，包括 1) 系统复杂性； 2）精度限制； 3) 视线限制或手术区域存在额外的电线。 我们对此 R21 可行性项目的具体目标如下： 目标 1：IOUS 和视频图像的实时融合：开发和评估创新光声方法，用于术中 US 与摄像机坐标系的实时、连续配准。目标 2：注册术前数据的实时跟踪：演示和评估 IOUS 和摄像机坐标中注册的术前模型的实时、连续跟踪和显示。目标 3：实时识别和跟踪 IOUS 中的间隙工具：开发在间隙工具上生成 PA 信号的照明和处理方法。演示和评估使用这些方法来定位用于实体器官肿瘤射频消融的典型探针的微小尖齿。 我们的基本假设是，通过术中光声 (PA) 成像方法的新颖应用，可以克服许多这些限制，从而允许直接、实时定位超声图像中的基准点。在 PA 成像中，激光的短脉冲被转换为可在超声图像中检测到的声信号。如果将多个激光点投射到器官表面，它们可以在视频和超声中定位，从而允许直接注册 IOUS 到相机的坐标。类似地，PA 成像可用于定位组织内的小型嵌入式标记，以允许实时跟踪注册的术前图像和相对于 IOUS 的模型。它可用于定位间质手术工具和探针上的点，从而允许相对于 IOUS 进行直接注册和跟踪。我们将评估在人工和离体模型以及小型体内试点研究中开发的技术。