Developmental Consequences of Pediatric TBI

儿童 TBI 的发育后果

• 批准号: 9111668
• 负责人: LINDA EWING-COBBS
• 金额: $ 55万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2018-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9111668
• 关键词: Developmental; Consequences; Pediatric; TBI

DESCRIPTION (provided by applicant): Traumatic brain injury leaves 17,000 children disabled yearly. Many children do not achieve their expected developmental trajectory after injury. Services exist for children with specific developmental disorders when they are known to be at risk for delays; however, children with traumatic brain injury frequently do not access these services. The overall goal of this project is to understand how traumatic brain injury affects children's development. This project is a longitudinal, prospective cohort study of children 0 to 15 years of age with all severities of traumatic brain injury. Children with traumatic brain injury and a comparison group of age and sex- matched children with orthopedic injury will be recruited from the two participating institutions. Specifically, the aims of this project are to fist characterize this cohort of children and age and sex matched orthopedic injury comparison children in relation to acute, post-acute and longer term treatments. We will characterize the children's family environment and cognitive and socio-emotional reserve as these may influence changes in children's short and longer term health status. Then, we will measure health specific outcomes during the first year after injury, including physical health, post-concussion symptoms, and stress. We will assess children's longer term developmental progress using growth curve analysis of key neuropsychological domains including cognition, social, and psychological health outcomes compared to children with orthopedic injuries. We will then use structural equation modeling to examine the relationships of injury severity, family environment, and neuropsychological status on children's ability to participate in everyday activities and perform i school. Finally, we will quantify children's health service use and health care costs for the year following injury. Results of this research will help to understand the complex interactions of preinjury family and child characteristics, post injury child deficits and family stress on childre's developmental outcomes. This information will be integrated with the children's current health service and school support service use in order to understand the barriers to services and inform the needed supports for children at each developmental stage.

描述（由申请人提供）：脑外伤每年17,000名残疾儿童。许多儿童受伤后没有达到预期的发育轨迹。当众所周知有延迟风险时，为患有特定发育障碍的儿童提供服务；但是，脑损伤的儿童经常无法获得这些 服务。该项目的总体目标是了解创伤性脑损伤如何影响儿童的成长。该项目是对0至15岁儿童的纵向，前瞻性队列研究，所有严重的脑损伤。创伤性脑损伤的儿童 将从两个参与机构中招募一个年龄和性匹配的骨科伤害儿童的比较组。具体而言，该项目的目的是抗击儿童的群体以及与急性，急性后和长期治疗有关的儿童的年龄和性别相匹配的骨科损伤比较。我们将表征儿童的家庭环境以及认知和社会情感储备，因为这些储备可能会影响儿童短期和长期健康状况的变化。然后，我们将在受伤后的第一年衡量健康特定的结果，包括身体健康，脑抑制症状和压力。我们将使用与骨科损伤儿童相比，使用关键神经心理学领域（包括认知，社会和心理健康成果）（包括认知，社会和心理健康成果）的成长曲线分析来评估儿童的长期发展进步。然后，我们将使用结构方程建模来检查受伤严重程度，家庭环境和神经心理学的关系，这些关系对儿童参加日常活动和表演I学校的能力。最后，我们将在受伤后的一年中量化儿童的卫生服务使用和医疗保健费用。这项研究的结果将有助于理解伤亡前家庭和儿童特征，伤害儿童缺陷以及家庭对Childre发育成果的压力的复杂相互作用。这些信息将与儿童当前的卫生服务和学校支持服务的使用集成，以了解服务的障碍并在每个发育阶段为儿童提供所需的支持。