GH16-006: Conducting Public Health Research in Kenya

GH16-006：在肯尼亚进行公共卫生研究

• 批准号: 9249936
• 负责人: Art Hapner
• 金额: $ 479.08万
• 依托单位: HENRY M. JACKSON FDN FOR THE ADV MIL/MED
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2021-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9249936
• 关键词: GH16; 006; Conducting; Public; Health

Abstract/Summary This proposal is submitted by the HJF Medical Research International (HJFMRI) in response to announcement RFA-GH-16-006, Conducting Public Health Research in Kenya, a funding opportunity from the Centers for Disease Control and Prevention (CDC). The purpose of this cooperative agreement is to conduct and monitor epidemiologic, clinical- and laboratory-based studies of important human diseases in Kenya. In collaboration with the Kenya Medical Research Institute (KEMRI), we are applying for Components A, B, C, D and E. For Component A, the Division of Global Health Protection, our proposal addresses, for example: surveillance for infectious zoonotic diseases in animals, covering causes of diseases in livestock and quantifying the linkages between the health of people and the animals with which they live; and the role of pathogens in acute febrile illness (AFI), characterizing the epidemiology, including seasonality of AFI. For Component B, our proposal covers, for example, identification of clinical, epidemiologic and nutritional characteristics of patients hospitalized with respiratory illness and risk factors, in settings like western Kenya, which may further predispose pregnant women to severe outcomes from influenza, especially in relationship to influenza vaccination. For Component C, we include proposed projects, such as determination of the effectiveness of patient delivered partner therapy in reducing Chlamydia trachomatis and Neisseria gonorrhea re-infection in conjunction with assessment of the prevalence and incidence of human immunodeficiency virus (HIV) infection. For Component D, for instance, we consider measuring schistosome antigens in oral fluid samples via detection of Circulating Cathodic Antigen (CCA) and present a sampling design to assess the therapeutic efficacy of Artemisinin-based combination therapies for symptomatic, uncomplicated P. falciparum infection among children. Finally, for Component E, for example, we propose a study to measure the effectiveness of three different strategies to increase the TB case detection rate compared to the standard approach, Directly Observed Treatment (DOTS) as implemented in Kenya. Each of our proposed projects is consistent with and beneficial to furthering CDC Kenya's mission to promote health through collaboration on science, policy and evidence-based public health actions. Collaborative public health research is HJFMRI's forte, and we offer our expertise in management to fulfill CDC strategic priorities.

摘要/摘要 该建议由国际HJF医学研究（HJFMRI）提交 公告RFA-GH-16-006，在肯尼亚进行公共卫生研究，这是一项资金 疾病控制与预防中心（CDC）的机会。这个目的 合作协议是进行和监测基于临床和实验室的流行病学学 肯尼亚重要人类疾病的研究。与肯尼亚医学合作 研究所（Kemri），我们正在申请组件A，B，C，D和E。对于组件 A，我们的提案解决了全球卫生保护部，例如：监视 对于动物的传染性人畜共患病，涵盖了牲畜疾病的原因 量化人们的健康与与之生活的动物之间的联系；和 病原体在急性发热疾病（AFI）中的作用，表征流行病学，包括 AFI的季节性。对于组件B，我们的建议涵盖了临床的识别， 患有呼吸道疾病的患者的流行病学和营养特征 危险因素，在肯尼亚西部等环境中，这可能会使孕妇更容易使孕妇更容易 流感的严重结果，尤其是与流感疫苗接种关系。为了 组件C，我们包括建议的项目，例如确定有效性 患者提供了伴侣治疗，以减少沙眼衣原体和淋病奈瑟氏菌 与人类的患病率和发病率的评估结合感染 免疫缺陷病毒（HIV）感染。例如，对于组件D，我们考虑测量 通过检测循环的阴极抗原（CCA），口服流体样品中的黑素抗原 并提出采样设计，以评估基于青蒿素的治疗功效 儿童中有症状，不复杂的恶性疟原虫感染的组合疗法。 最后，例如，对于组件E，我们提出了一项研究来衡量的有效性 与标准相比，提高结核病病例检测率的三种不同策略 方法，直接观察到肯尼亚实施的治疗（点）。我们的每个 拟议的项目与肯尼亚CDC的使命是一致的，并且有益于 通过科学，政策和循证公共卫生的合作来促进健康 动作。协作公共卫生研究是HJFMRI的Forte，我们提供了我们的专业知识 履行CDC战略重点的管理。