Connectomes Related to Anxiety and Depression in Adolescents

与青少年焦虑和抑郁相关的连接组

• 批准号: 9234808
• 负责人: JOHN GABRIELI
• 金额: $ 4.7万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-06 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9234808
• 关键词: 15 year old; Accidents; Acute; Adherence; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Affect; Age; Amygdaloid structure; Anxiety; Anxiety Disorders; Area; Atlases; Attention; Base of the Brain; Behavioral; Biological Neural Networks; Boston; Cause of Death; Clinic; Clinical; Collaborations; Communities; Corpus striatum structure; Data; Data Collection; Data Set; Detection; Development; Diagnosis; Diagnostic; Diffusion Magnetic Resonance Imaging; Disease; Emotions; Expectancy; Face; Fright; Functional Magnetic Resonance Imaging; Funding Opportunities; Gambling; General Hospitals; Health; Hospitals; Human; Image; Institutes; Literature; Longevity; Magnetic Resonance Imaging; Massachusetts; Measures; Medial; Mental Depression; Mental disorders; Methods; Midbrain structure; Mood Disorders; Morphologic artifacts; National Institute of Mental Health; Negative Valence; Participant; Patient Self-Report; Patients; Physiological; Plant Roots; Positioning Attribute; Positive Valence; Prefrontal Cortex; Protocols documentation; Psychiatric Diagnosis; Public Health; Recruitment Activity; Research; Research Domain Criteria; Research Personnel; Resources; Rest; Rewards; Sampling; Source; Staging; Structure; Substance abuse problem; Suicide; System; Technology; United States National Institutes of Health; Universities; Variant; Ventral Striatum; Ventral Tegmental Area; Washington; bioimaging; conditioned fear; connectome; experience; fly; human disease; interest; meetings; neuroimaging; prisma; reconstruction; response; reward expectancy; tool; white matter

 DESCRIPTION (provided by applicant): This proposal is submitted in response to NIH Funding Opportunity Connectome Related to Human Disease (U01) and in response to NIMH's priority/disease area of interest mood and anxiety disorders. This is a collaborative effort among researchers at the Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), McLean Hospital, Boston University, and the Human Connectome Project (HCP) at Washington University in St. Louis. We believe that the combination of (1) state-of-the art MRI technology and methods at the MGH Martinos Center for Biomedical Imaging, (2) an active collaboration with the HCP to validate neuroimaging harmonization, (3) a Boston-wide consortium of experienced and expert clinical researchers, and (4) a transdiagnostic focus across the anxiety and depression spectrum can deliver a high- quality dataset that meets the specification of the Funding Opportunity. We propose to focus on an area of great clinical need and public health implication: better understanding of psychiatric disorders in adolescence. We target anxiety and depression as diseases that affect many adolescents across multiple traditional psychiatric diagnoses, that are strongly associated with two leading causes of death in adolescents and young adults (suicide and substance-abuse related accidents), and that are understood to frequently have developmental roots leading to lifelong psychiatric disorders. Our research approach is guided by two principles (1) careful adherence to HCP protocols so as to develop large-scale, integrated, and growing data sets available to the scientific community, and (2) a research approach aligned with two constructs from the NIMH Research Domain Criteria Project (RDoC), specifically: (a) the "Acute Threat/Fear" construct, which is associated with atypical structure and function in specific neural networks, especially amygdala, orbitofrontal cortex (OFC), and ventral medial prefrontal cortex (vmPFC); and (b) the "Reward Prediction Error" construct, which is associated with OFC, ventral striatum, and the midbrain ventral tegmental area. Across four years we aim to (1) operationalize MRI data collection and behavioral characterization that is harmonized and validated with the Human Connectome Project (HCP); (2) recruit and characterize clinically and behaviorally, 225 adolescents ages 14-15 with and without anxiety and/or depression (180 patients, 45 controls); and (3) perform and analyze HCP imaging with participants. We hypothesize that greater activation in the amygdala-OFC circuit will correlate with more severe scores on measures of fear, and that lesser activation of the striatal-OFC circuit will correlate with more severe scores on measures of reward-error expectancy. We will also (a) examine whether neuroimaging analyses are enhanced with artifact-detection tools and physiological aliasing correction that are publicly available and could be integrated with the HCP, and (b) create an age-specific human tract atlas and tools for automated reconstruction of white-matter tracts involved in the above circuits, which will also be made publicly available.

 描述（由申请人提供）：本提案是为了响应 NIH 与人类疾病相关的资助机会连接组（U01）以及响应 NIMH 感兴趣的情绪和焦虑症优先/疾病领域而提交的，这是研究人员之间的合作努力。马萨诸塞州总医院 (MGH)、麻省理工学院 (MIT)、麦克莱恩医院、波士顿大学和圣路易斯华盛顿大学人类连接组项目 (HCP) 的结合，我们相信。 (1) MGH Martinos 生物医学成像中心最先进的 MRI 技术和方法，(2) 与 HCP 积极合作以验证神经影像协调性，(3) 波士顿范围内经验丰富的专家临床联盟研究人员，以及（4）跨焦虑和抑郁谱系的跨诊断焦点可以提供符合资助机会规范的高质量数据集。我们建议重点关注具有巨大临床需求和公共卫生影响的领域：更好。的理解我们将焦虑和抑郁视为影响许多青少年的疾病，涉及多种强烈传统的精神病学诊断，它们与青少年和年轻人死亡的两个主要原因（自杀和药物滥用相关事故）有关，并且被认为经常与发育障碍有关。我们的研究方法遵循两个原则：(1) 遵守 HCP 协议，以便开发可供科学界使用的大规模、综合且不断增长的数据集，以及 (2) 一致的研究方法。有两个构造来自 NIMH 研究领域标准项目 (RDoC)，具体而言：(a) “急性威胁/恐惧”构造，与特定神经网络中的非典型结构和功能相关，特别是杏仁核、眶额皮质 (OFC) 和腹内侧前额皮质 (vmPFC)；以及 (b) “奖励预测误差”结构，与 OFC、腹侧纹状体和中脑腹侧相关在四年内，我们的目标是 (1) 实施与人类连接组项目 (HCP) 协调和验证的 MRI 数据收集和行为表征；(2) 招募 225 名 14-15 岁的青少年并对其进行临床和行为表征。没有焦虑和/或抑郁（180 名患者，45 名对照）；（3）与参与者一起进行和分析 HCP 成像，我们探索了杏仁核-OFC 回路的更大激活。与更严重的恐惧测量得分相关，并且纹状体-OFC 回路的较少激活将与更严重的奖励错误预期测量得分相关。我们还将（a）检查神经影像分析是否因伪影而得到增强。公开可用且可与 HCP 集成的检测工具和生理混叠校正，以及 (b) 创建特定年龄的人体神经束图谱和工具，用于自动重建上述回路中涉及的白质束，这也将是制成公开可用。