Inflammatory Biomarkers of Diagnosis and Prognosis in Early Stage Lung Cancer

早期肺癌诊断和预后的炎症生物标志物

• 批准号: 9343984
• 负责人: Brid Ryan
• 金额: $ 26.61万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9343984
• 关键词: Address; American; Benign; Biological Markers; Clinical; Cytokine Signaling; Detection; Diagnosis; Diagnostic; Dose; Early Diagnosis; European; Goals; Health; Human; Inflammatory; Knowledge; Lesion; Lung; Lung nodule; Malignant - descriptor; Malignant neoplasm of lung; Methods; Modeling; Operative Surgical Procedures; Patients; Plasma; Prognostic Marker; Prospective Studies; Public Health; Recurrence; Relapse; Risk; Sampling; Specificity; Spiral Computed Tomography; Staging; Translating; cancer diagnosis; chemotherapy; clinical decision-making; cytokine; experience; low-dose spiral CT; mortality; outcome forecast; prognostic signature; screening; tool; tumor

Building on our previous studies where we found increased circling cytokines among patients with a lung cancer diagnosis, we are examining plasma samples from the National Lung Screening Trial for a cytokine diagnostic and prognostic signature. This study extends previous studies as a) this is a prospective study and b) the lesions both benign and malignant, were detected b low dose helical CT. We are also examining whether the signal from cytokines declines following surgery and tracks with tumor recurrence, as a preliminary study to query whether cytokines could be used to model tumor recurrence. This study is currently ongoing. We are also comparing different cytokine detection platforms and determining the best and most robust method of biomarker detection.

基于我们之前的研究，我们发现肺癌诊断患者的循环细胞因子增加，我们正在检查国家肺部筛查试验的血浆样本，以了解细胞因子诊断和预后特征。这项研究扩展了之前的研究，因为 a) 这是一项前瞻性研究，b) 通过低剂量螺旋 CT 检测到良性和恶性病变。我们还在检查手术后细胞因子的信号是否会减弱并跟踪肿瘤复发，作为询问细胞因子是否可用于模拟肿瘤复发的初步研究。这项研究目前正在进行中。我们还比较不同的细胞因子检测平台，并确定最佳和最稳健的生物标志物检测方法。

项目成果

Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer.

• DOI: 10.1158/0008-5472.can-14-2101
• 发表时间: 2015-02-01
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Ryan BM;Robles AI;McClary AC;Haznadar M;Bowman ED;Pine SR;Brown D;Khan M;Shiraishi K;Kohno T;Okayama H;Modali R;Yokota J;Harris CC
• 通讯作者: Harris CC