Cajal-Retzius cells and neuronal signaling in postnatal cortical networks

出生后皮质网络中的 Cajal-Retzius 细胞和神经元信号传导

基本信息

批准号：
8990891
负责人：
Gianmaria MACCAFERRI
金额：
$ 42.03万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-01-15 至 2019-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8990891
关键词：
Adult Architecture Brain Cajal-Retzius cells Coupled Data Development Disease Electrophysiology (science)Elements Epilepsy Febrile Convulsions Feedback Funding Glutamate Receptor Glutamates Health Hippocampal Formation Hippocampus (Brain)In Vitro Interneurons Knowledge Laboratories Mediating Mental disorders N-Methylaspartate Nature Neurodevelopmental Disorder Neurologic Neurons Neurotransmitters Output Pathologic Processes Pathway interactions Physiological Play Population Heterogeneity Property Publishing Pyramidal Cells Regulation Role Seizures Sensory Shapes Side Synapses Synaptic Transmission Synaptic plasticity Techniques Testing Work base career cell type entorhinal cortex granule cell in vivo in vivo Model insight juvenile animal migration nervous system disorder neural circuit neuron development neuronal circuitry neurotransmission neurotransmitter release novel novel therapeutic intervention novel therapeutics optogenetics postnatal postsynaptic prevent research study spatial memory transmission process

项目摘要

DESCRIPTION (provided by applicant): The immature brain is not a small sized version of the adult brain: its circuits are profoundly different and much less understood. Therefore, studying how neural circuits take shape is essential for several reasons. First, it is important to understand how the normal brain works. Second, it is critical to gain insights into how abnormal brain development contributes to neurological and mental health disorders. Third and last, it is required for a rational approach to create novel therapeutic strategies for diseases that are currently untreatable. Cajal-Retzius cells are transient neurons that play important functions during mammalian corticogenesis, such as control of neuronal migration and cortical lamination. However, their fast network/computational roles, mediated by synaptic transmission, remain rather mysterious and poorly understood. Based on the work that we have already published and on the preliminary data collected during these last three and a half years of funding, we propose to test the overarching hypothesis that Cajal-Retzius cells of the developing hippocampus are an essential component of a microcircuit that is involved, physiologically, in the regulation of synaptic plasticity of specific hippocampal connections, but may also contribute to the well-known vulnerability of this region to seizures. This project has a direct translational relevance because a deeper understanding of cellular mechanisms involved in network functions of the maturing brain is critical to provide insights for novel therapeutic approaches in neurodevelopmental disorders.

描述（由申请人提供）：未成熟的大脑不是成人大脑的小尺寸版本：它的电路截然不同且理解较少。因此，研究神经回路的形成是必不可少的，原因有几个。首先，了解正常大脑的工作原理很重要。其次，了解脑发育异常如何促进神经和心理健康障碍，这一点至关重要。第三也是最后，有理理性的方法是为目前无法治疗的疾病创建新颖的治疗策略所必需的。 Cajal-Retzius细胞是瞬时神经元，在哺乳动物皮质生成过程中起着重要功能，例如控制神经元迁移和皮质层压。但是，它们的快速网络/计算角色是由突触传播介导的，仍然是神秘且知之甚少的。基于我们已经发表的工作以及在过去三年半的资金中收集的初步数据，我们建议测试开发海马的Cajal-Retzius细胞的总体假设，即海马的重要组成部分是微电路的重要组成部分，在生理上是造成这种特殊性的相关性，但在生理学上涉及的繁殖型，但也可能会造成较大的塑料，但可能会造成较大的塑料，但可能会造成较大的塑料。癫痫发作。这个项目有直接的翻译相关性是因为对成熟大脑网络功能所涉及的细胞机制有更深入的了解对于为新颖的治疗方法提供见解至关重要神经发育障碍。