PillStream: Agile High-Throughput Assembly of Custom Multi-Medication Packaging

PillStream：定制多种药物包装的敏捷高通量组装

基本信息

批准号：
8743825
负责人：
Edward Acworth
金额：
$ 39.93万
依托单位：
MOSAIC LOFT
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-27 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8743825
关键词：
Applications Grants Beds Bulla Capital Capital Financing Cessation of life Color Computer software Custom Development Discipline of Nursing Dose Drug Packaging Drug Prescriptions Engineering Floor Funding Gelatin Generations Goals Healthcare Systems Hour Industry Letters Long-Term Care Manuals Measurable Medication Errors Methods Modeling Nursing Homes Nursing Staff Oral Patients Performance Persons Pharmaceutical Preparations Pharmacy facility Phase Production Regulation Request for Applications Risk Robot Robotics Safety Services Site Skilled Nursing Facilities Small Business Innovation Research Grant Solid Solutions Sorting - Cell Movement Source Speed Stream System Technology Testing Time United States Centers for Medicare and Medicaid Services capsule commercialization cost design dosage flexibility meetings novel pill prototype public health relevance success wasting

Applications Grants Beds Bulla Capital Capital Financing Cessation of life Color Computer software Custom Development Discipline of Nursing Dose Drug Packaging Drug Prescriptions Engineering Floor Funding Gelatin Generations Goals Healthcare Systems Hour Industry Letters Long-Term Care Manuals Measurable Medication Errors Methods Modeling Nursing Homes Nursing Staff Oral Patients Performance Persons Pharmaceutical Preparations Pharmacy facility Phase Production Regulation Request for Applications Risk Robot Robotics Safety Services Site Skilled Nursing Facilities Small Business Innovation Research Grant Solid Solutions Sorting - Cell Movement Source Speed Stream System Technology Testing Time United States Centers for Medicare and Medicaid Services capsule commercialization cost design dosage flexibility meetings novel pill prototype public health relevance success wasting

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项目摘要

DESCRIPTION (provided by applicant): Errors in the administration of medications to residents of long-term care facilities (LTCFs) threaten resident safety and add significant unnecessary costs to the healthcare system. Use of unit dose medications that require LTCF staff to manually sort and assemble specific patient medications ~4 times per day can result in error rates as high as 42%, with 7% of total errors having significant potential for harm. Just preparing medications for administration consumes an estimated 6-8 person hours/day in a typical 100 resident LTCF, or an estimated 16,000 full time equivalents in all US LTCFs, reducing staff time available for other functions. Another unnecessary cost, estimated at $5 billion in US nursing homes alone, arises from medications that are wasted due to prescription changes and patient turnover. New regulations from the Centers for Medicare and Medicaid Services, effective 1 January 2013, target reduced medication waste by requiring "short cycle" fills (d14 days) instead of the traditional 30 day "bingo cards". However, even if this has the desired result of reducing prescription drug waste, industry sources predict that use of shorter cycle bingo cards may increase LTCF staff time and possibly errors associated with additional manual sorting of more unit dose packages. Proposed Solution. Artaic's novel PillStreamTM system incorporates proven advanced agile manufacturing technology, utilized in our successful TileJet robot developed for high speed low-cost mosaic just-in-time manufacturing. PillStream is designed for high accuracy, high throughput production of Custom Multi-medication Packages (CMPTM) that will enable Central-Fill pharmacies to provide their LTCF customers with short cycle dispensing at reduced cost and with closed-loop capability enabling return of unused medications. In SBIR Phase I we created a PillStream prototype that exceeded our primary success criterion of e99.9% placement accuracy for surrogate pills and gelatin capsules while exceeding our target fill rate (100 blisters/min) by 50%. Specific Aims. In this 24-month Phase II SBIR we propose to: 1) build and test a larger fully functional Pill- Stream prototype able to dispense up to 48 "fast mover" pills/capsules directly from wholesale medication bottles; 2) modify the onboard PS48 software to enable integration with pharmacy management software; and 3) beta test the PS48 in up to 2 Central-Fill pharmacies, using it to fill daily patient-specifc CMPs containing "fast mover" medications in order to compare accuracy and cost to existing methods. Success in meeting our target SBIR Phase II engineering specifications for accuracy (e99.99%) and throughput (e100 blisters/min and e10 daily CMPs/minute) in a real Central-Fill pharmacy setting should enable Artaic to raise Phase III funds for commercial production of PS48 and larger PS100 and PS200 units.

描述（由申请人提供）：为长期护理设施（LTCFS）施用药物的错误威胁居民安全，并为医疗保健系统增加了大量不必要的费用。使用单位剂量药物，要求LTCF员工每天手动分类和组装约4次的特定患者药物可能会导致错误率高达42％，其中7％的总误差具有巨大的伤害潜力。仅准备用于管理药物的药物在典型的100个居民LTCF中估计会消耗大约6-8人的小时时间，或者在所有美国LTCF中估计有16,000个全职等效物，减少了其他功能的员工时间。另一个不必要的成本，仅在美国疗养院中估计有50亿美元，这是由于处方改变和患者流动而浪费的药物。 Medicare和Medicaid Services中心的新法规，自2013年1月1日起，目标是减少药物浪费，而不是“短周期”填充（D14天），而不是传统的30天“宾果卡”。但是，即使这是减少处方药物浪费的预期结果，行业消息来源也预测，使用较短的循环宾果卡可能会增加LTCF员工的时间，并可能与更多单位剂量软件包进行手动分类有关的错误。建议的解决方案。 Artaic的小说Pillstreamtm系统结合了经过验证的先进的敏捷制造技术，该技术用于我们成功的瓷砖机器人，用于高速低成本的马赛克即时制造。 PillStream的设计旨在高精度，高吞吐量的定制多物种软件包（CMPTM），这将使中央填充药房能够为其LTCF客户提供以降低成本和闭环能力的短期分配，从而使未使用药物的回报。在SBIR I期中，我们创建了一个药丸原型，该原型超过了替代药丸和明胶胶囊的E99.9％放置精度的主要成功标准，同时超过了我们的目标填充率（100个水泡/分钟）乘以50％。具体目标。在这个24个月的II阶段SBIR中，我们建议：1）构建和测试一个较大的功能性药水原型，能够直接从批发药物瓶中直接分配48个“快速移动”药丸/胶囊； 2）修改板载PS48软件以使其与药房管理软件集成； 3）Beta测试PS48在多达2个中央填充药房中测试PS48，使用它填充日常的患者规格CMP，其中含有“快速搬运”药物，以将准确性和成本与现有方法进行比较。在真正的中央填充药房设置中，成功满足了我们的目标SBIR II期工程规范（E99.99％）和吞吐量（E100 Plisters/min和E10每日CMP/MINUNE），应使Artaic能够筹集III期资金，用于PS48和更大的PS100和PS200单元的商业生产。