P-30 Core Grant for Vision Research

P-30 视觉研究核心补助金

• 批准号: 9144390
• 负责人: Janey L Wiggs
• 金额: $ 60.9万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9144390
• 关键词: Affect; Antibiotic Resistance; Basic Science; Biometry; Cellular biology; Center Core Grants; Clinical; Clinical Data; Collaborations; Collection; Complex; Core Grant; Data; Degenerative Disorder; Development; Diagnosis; Diagnostic; Disease; Ear; Event; Eye; Eye Infections; Eye diseases; Faculty; Faculty Recruitment; Funding; Gene Expression Profiling; Genetic; Genomics; Goals; Health; Infection; Institution; Knowledge; Link; Massachusetts; Modality; Molecular; Molecular Biology; Ophthalmology; Patient Care; Patients; Productivity; Research; Research Personnel; Research Support; Resources; Risk Factors; Sampling; Scientist; Therapeutic; Translations; Vision; Vision Disorders; Vision research; base; biobank; clinically relevant; genomic data; medical schools; novel; personalized medicine; programs; ranpirnase; Affect; Antibiotic Resistance; Basic Science; Biometry; Cellular biology; Center Core Grants; Clinical; Clinical Data; Collaborations; Collection; Complex; Core Grant; Data; Degenerative Disorder; Development; Diagnosis; Diagnostic; Disease; Ear; Event; Eye; Eye Infections; Eye diseases; Faculty; Faculty Recruitment; Funding; Gene Expression Profiling; Genetic; Genomics; Goals; Health; Infection; Institution; Knowledge; Link; Massachusetts; Modality; Molecular; Molecular Biology; Ophthalmology; Patient Care; Patients; Productivity; Research; Research Personnel; Research Support; Resources; Risk Factors; Sampling; Scientist; Therapeutic; Translations; Vision; Vision Disorders; Vision research; base; biobank; clinically relevant; genomic data; medical schools; novel; personalized medicine; programs; ranpirnase

DESCRIPTION (provided by applicant): The Massachusetts Eye and Ear Infirmary (MEEI) is an internationally-recognized leading institution for academic ophthalmology and vision research. MEEI is the primary institution for the Department of Ophthalmology at Harvard Medical School, one of the largest academic departments of Ophthalmology world-wide. The overall purpose of this P30 Center Core Grant for Vision Research is to enhance the research capabilities at the Massachusetts Eye and Ear Infirmary (MEEI) by providing resources that would not otherwise be available to investigators who are PIs of NEl-funded ROIs. The Core resources has increased research productivity, supported collaborative research, supported young investigators and have contributed to successful faculty recruitment. Through collaboration with MEEI vision scientists new faculty have been attracted to vision research. This P30 competing renewal requests funds to support three resource cores: Genomics, (Eric Pierce director), will provide access to state-of-the-art genomic resources; BioBank, (Janey Wiggs, director) will support the collection of patient-related samples and provide support for linking patient material with genomic and clinical data; and Biostatistics (Louis Pasquale, director) will provide resources and support for a variety of statistical analyses including geneti associations, power calculations and analysis of gene expression data. These resources form the basis of an integrated research plan that enhances the research capabilities at MEEI and in particular supports translation of basic science discoveries to clinically relevant information. Four general research themes are supported by this research plan: Genetics and genomics of ocular disease, identification of risk factors for common complex ocular disease, defining the molecular basis of ocular infection and antibiotic-resistant infections, and the cell and molecular biology of neuro-degenerative conditions affecting the eye. The overarching goals are to define the risk factors and molecular events contributing to blinding eye disease as the initial steps toward the development of novel disease-based diagnostic and therapeutic modalities with the ultimate goal of promoting personalized medicine for ocular disorders.

描述（由申请人提供）：马萨诸塞州的眼睛和耳科医院（MEEI）是一家国际公认的学术眼科和视力研究的领先机构。 MEEI是哈佛医学院眼科科的主要机构，哈佛医学院是全球眼科最大的学术部门之一。这项P30中心核心研究的总体目的是通过提供否则将无法提供NEL资助的Rois的调查人员提供的资源来增强马萨诸塞州眼科医院（MEEI）的研究能力。核心资源提高了研究生产力，支持合作研究，支持年轻的研究人员，并为成功的教师招聘做出了贡献。通过与MEEI视觉科学家的合作，新教师被视觉研究所吸引。 P30竞争的续约要求资金支持三个资源核心：基因组学（Eric Pierce主管）将提供获得最先进的基因组资源的访问权限； Biobank（Janey Wiggs，董事）将支持与患者相关样品的收集，并为将患者材料与基因组和临床数据联系起来提供支持；和生物统计学（Louis Pasquale，董事）将为包括Geneti关联，功率计算和基因表达数据分析在内的各种统计分析提供资源和支持。这些资源构成了一项综合研究计划的基础，该计划增强了MEEI的研究能力，特别是支持将基础科学发现转化为临床相关信息。该研究计划支持了四个一般研究主题：眼科疾病的遗传学和基因组学，常见复杂眼疾病的危险因素，定义了眼感染和抗生素耐药性感染的分子基础，以及细胞和分子 影响眼睛的神经脱生条件的生物学。总体目标是定义危险因素和分子事件，导致眼科疾病是发展基于新型疾病的诊断和治疗方式的初步步骤，其最终目标是促进针对眼部疾病的个性化医学。