Aging in 1000 healthy young adults: the Dunedin Study

1000 名健康年轻人的衰老：达尼丁研究

基本信息

批准号：
9134648
负责人：
AVSHALOM CASPI
金额：
$ 52.94万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-03-01 至 2020-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9134648
关键词：
Age Aging Archives Asthma Basic Science Behavioral Biological Biological Aging Biological Markers Birth Blood Cardiovascular Diseases Caring Cause of Death Childhood Cities Clinical Cognitive DNA Data Data Collection Data Set Dementia Deterioration Development Diagnosis Disease Drug Insurance Economics Education Elderly Epigenetic Process Face Fertility Rates Future Genetic Genomics Goals Government Half-Life Health Heritability Human Individual Infant International Intervention Knowledge Leukocytes Life Life Cycle Stages Life Expectancy Link Longevity Longitudinal Studies Maintenance Measures Medical Methods Methylation Modeling Molecular Non-Insulin-Dependent Diabetes Mellitus Obesity Onset of illness Paper Pathogenesis Personal Attribute Personality Persons Physiological Plant Roots Policy Maker Population Prevalence Primary Health Care Process Protocols documentation Psychopathology Public Health Readiness Records Research Risk Risk Factors Scoring Method Smoking Social Welfare Social Work Specific qualifier value Staging Surveys System Testing Tissues Translations Update Variant Work adverse outcome age related aging population base biobank body system clinical practice cohort cost disability early onset economic cost endophenotype experience follow-up genetic profiling genome wide association study genomic signature health care service health record improved member middle age multidisciplinary neglect peer prevent research and development simulation social telomere theories tool young adult

项目摘要

DESCRIPTION (provided by applicant): Declining fertility rates, aging of the baby-boomers, and increasing life expectancy are leading to population aging. As the population ages, this increases the public-health burden of age-related conditions, such as cardiovascular disease, type 2 diabetes, and dementia. Treating un-prevented diseases in late life has proven costly and ineffective. It is now known that potentially preventable risk exposures and physiological causes of age-related disease emerge in childhood. This recognition lends new scientific significance to studies that have followed cohorts from childhood. It is also now known that the pathogenesis of age-related diseases involves gradually accumulating decline in organ systems, beginning in the first half of the life course. Consequently, new interventions aiming to prevent age-related diseases will have to be applied to individuals while they are yet young, before they reach midlife. Translation of basic-science geronotology discoveries into interventions for young humans is lacking because virtually nothing is known about the process of biological aging during the first half of the life course. This prompts our proposal to study the pace of biological aging from the twenties forward. We will use the Dunedin Multidisciplinary Health & Development Study, a longitudinal study of a birth cohort now entering its fifth decade. This study combines methods of demographic/economic surveys, clinical- quality health assessments, biobanking, and linkage to nationwide administrative records (health, welfare, finances). We propose to administer a full-day data-collection protocol to the 1004 living members of the birth cohort. To assess each cohort member's pace of biological aging we will: (a) measure biomarkers across multiple organ systems, and (b) statistically model correlated change in these biomarkers assessed at ages 26, 32, 38, and 45 years. We will describe individual variation in the pace of aging, plus its developmental origins, genomic signatures, functional consequences, and economic costs. We will identify attributes that set apart individuals whose bodies are months or years younger than their chronological age. The proposed work will improve knowledge by generating findings to support future interventions to slow aging, prevent age-related disease, and improve the quality of longer lives.

描述（由适用提供）：生育率下降，婴儿潮一代的老化以及预期寿命的增加正在导致人口衰老。随着人口的年龄增长，这会增加与年龄有关的疾病的公共卫生燃烧，例如心血管疾病，2型糖尿病和痴呆症。在晚期治疗未预防的疾病已被证明是昂贵和无效的。现在众所周知，可能可以预防的风险暴露和与年龄有关的疾病出现的生理原因。这种认识为从童年时期遵循的研究的研究提供了新的科学意义。现在，众所周知，与年龄有关的疾病的发病机理涉及从生命过程的上半年开始逐渐积累器官系统下降。因此，新的干预措施旨在防止与年龄相关的疾病，必须在年轻的人到达中年之前将其应用于个人。缺乏将基本科学的老年学发现为年轻人的干预措施的翻译，因为在生命过程的上半年，几乎对生物衰老的过程一无所知。这提示了我们研究生物学空间的建议二十多岁的衰老。我们将使用Dunedin多学科健康与发展研究，这是一项纵向研究，研究了现在进入其第五个十年的出生队列。这项研究结合了人口/经济调查，临床质量健康评估，生物群体以及与全国行政记录（健康，福利，财务）联系的方法。我们建议对出生队列的1004名生活成员进行全天数据收集方案。为了评估每个队列成员的生物衰老速度，我们将：（a）测量跨多个器官系统的生物标志物，以及（b）在26、32、38和45岁时评估的这些生物标志物的统计相关变化。我们将描述衰老速度的个人变化，以及其发育起源，基因组签名，功能后果和经济成本。我们将确定将身体分开的属性比年龄年龄小几个月或年龄。拟议的工作将通过产生发现来改善知识，以支持将来的干预措施，以减缓衰老，预防与年龄相关的疾病并改善寿命更长的质量。