Biostatistics Facility Core

生物统计设施核心

• 批准号: 9084552
• 负责人: Pamela Ann Ohman-Strickland
• 金额: $ 10.61万
• 依托单位: RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9084552
• 关键词: Address; Basic Science; Biological; Biology; Biometry; Clinical; Clinical Research; Communities; Community Health; Core Facility; Development; Disease; Educational Curriculum; Educational Materials; Environment; Environmental Exposure; Environmental Health; Epigenetic Process; Exposure to; Federal Government; Fostering; Funding; Future; Genome; Genomics; Government Agencies; Grant; Health; Health Policy; Health Professional; Human; Integration Host Factors; Intervention; K-Series Research Career Programs; Lead; Link; Local Government; Mentors; Mission; Modeling; National Institute of Environmental Health Sciences; Outcome; Pathogenesis; Pilot Projects; Population Research; Prevention strategy; Public Health; Public Policy; Regulation; Research; Research Personnel; Science; State Government; Statutes and Laws; Structure; Technology; Training; Translating; Vision; cost effective; data integration; disorder prevention; disorder risk; epigenome; epigenomics; improved; innovation; population based; precision medicine; prevent; programs; response; risk mitigation; treatment strategy

The mission of the Center for Environmental Exposure and Disease (CEED) is to improve human health by performing transdisciplinary research to elucidate how the total environment, the genome and the epigenome interact to mitigate the risk of disease. CEED research focuses on: 1) assessing and modeling exposures, 2) discovering and applying biological response indicators which link exposures to mechanisms of pathogenesis, 3) developing and implementing targeted prevention, intervention, and treatment strategies, 4) reducing exposures by influencing public policy, planning and regulation, and 5) engaging and informing stakeholders. By analogy with Precision Medicine, CEED envisions that the integration of data from exposure biology, genomics, epigenetics and microbiomics to assess exposures, biological responses, mechanisms of pathogenesis and disease prevention will significantly impact the future of environmental health. The CEED vision is to lead the development of precision environmental health research through the integration of clinical, basic, and population-based studies, using the acquired information to prevent and/or treat environmental disease. The strategy is to combine the Center's long-standing breadth and depth of expertise in environmental health research with new capabilities in exposure biology, epigenomics, and microbiomics. The Specific Aims are: Aim 1: Move basic, clinical and population research toward precision environmental health by: i) fostering a collaborative, transdisciplinary research environment, ii) supporting innovative research and emerging science through Pilot grant funding, and iii) providing cost-effective access to Facility Cores that maintain state-of-the-art technologies and expertise. Aim 2: Provide training and mentoring opportunities to junior investigators and established researchers in innovative and emerging environmental health research through: i) mentoring committees and a structured mentoring curriculum, ii) collaborative research, iii) Career Development Awards and Pilot Project grants, and iv) opportunities for expanded training with other NIEHS Centers. Aim 3: Strengthen and expand existing relationships with community partners by: i) facilitating bidirectional interactions among CEED researchers and community partners to identify environmental concerns and desired outcomes, ii) developing research programs that address community health needs, and iii) providing research results, educational materials and expertise to communities and health professionals, enabling them to minimize exposures and influence public health policy. Aim 4: Translate research findings to stakeholders in local, state and federal government agencies to provide guidance on mitigation of risk, to influence public policy, and to support legislation that reduces exposure and improve environmental health.

环境暴露与疾病中心（CEED）的使命是通过 进行跨学科研究以阐明总环境，基因组和表观基因组如何 相互作用以减轻疾病的风险。 CEED研究重点是：1）评估和建模暴露，2） 发现和应用生物反应指标，这些指标将暴露与发病机理联系起来， 3）制定和实施有针对性的预防，干预和治疗策略，4）减少 通过影响公共政策，计划和法规以及5）参与并告知利益相关者的暴露。 通过与精确医学类似，CEED想象的是，来自暴露生物学的数据的整合， 基因组学，表观遗传学和微生物学评估暴露，生物学反应，机制 发病机理和疾病预防将极大地影响环境健康的未来。 CEED 愿景是通过整合临床，领导精确环境健康研究的发展， 基础和基于人群的研究，使用获得的信息来预防和/或治疗环境 疾病。该策略是结合中心的长期广度和深度专业知识 环境卫生研究具有新的能力，在暴露生物学，表观基因组学和微生物学方面。这 具体目的是：目标1：将基本，临床和人口研究转向精确环境健康 作者：i）培养协作，跨学科研究环境，ii）支持创新研究和 通过飞行员赠款资金和iii）提供了新兴的科学 维护最先进的技术和专业知识。目标2：提供培训和指导机会 初级研究人员和成立的创新和新兴环境健康研究的研究人员 通过：i）指导委员会和结构化指导课程，ii）合作研究，iii）职业 开发奖和试点项目赠款以及IV）与其他NIEHS扩大培训的机会 中心。目标3：加强与社区合作伙伴的现有关系：i）促进 CEED研究人员和社区合作伙伴之间的双向互动，以确定环境 关注和期望的结果，ii）制定满足社区健康需求的研究计划，以及 iii）为社区和卫生专业人员提供研究结果，教育材料和专业知识， 使他们能够最大程度地减少暴露并影响公共卫生政策。目标4：将研究发现转化为 地方，州和联邦政府机构的利益相关者提供有关缓解风险的指导， 影响公共政策，并支持减少曝光率并改善环境健康的立法。