Biomechanics and Multimodal Tissue Imaging Core

生物力学和多模态组织成像核心

• 批准号: 8695292
• 负责人: Edward M. Schwarz
• 金额: $ 31.52万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8695292
• 关键词: Algorithms; Allografting; Anatomy; Animal Model; Animals; Arthritis; Award; Biochemistry; Biology; Biomechanics; Cells; Center Core Grants; Clinical; Collaborations; Complement; Country; Disease; Ensure; Equipment; Fee-for-Service Plans; Fracture Healing; Funding; Future; Goals; Grant; Growth; Healed; Histologic; Histology; Histopathology; Histopathology Facility; Image; Image Analysis; Individual; Instruction; Laboratories; Medicine; Modification; Molecular; Molecular Biology; Muscular Dystrophies; Musculoskeletal; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Orthopedics; Outcome Measure; Peer Review; Physicians; Productivity; Publications; Quality Control; Recruitment Activity; Research; Research Personnel; Resources; Scientist; Services; Signal Pathway; Slide; System; TNFRSF5 gene; Technology; Testing; Tissues; Training; Translating; Translational Research; Translations; Trauma; Ultrasonography; United States National Institutes of Health; Universities; X-Ray Computed Tomography; animal tissue; base; bench to bedside; cost effective; design; experience; healing; image processing; imaging modality; improved; in vivo; in vivo imaging; injury and repair; innovation; instrument; interdisciplinary approach; minimally invasive; molecular imaging; novel; professor; programs; repaired; skeletal; success; trauma care

The Biomechanics and Multimodal Tissue Imaging (BMTI) Core is being proposed as a result of strategic restructuring of resources in the Center for Musculoskeletal Research (CMSR), in order to improve efficiency, accelerate the pace of research, and facilitate clinical translation of our NIH funded programs. As the research in the CMSR has moved in increasingly translational directions, including many animal models of orthopaedic injury and repair (e.g. arthritis, fracture healing, and allograft healing), there has been a compelling rationale for integrating histologic, tissue- and cell-based studies with longitudinal animal imaging and tissue biomechanical assessments, in pursuit of minimally-invasive outcome measures of healing and repair that can be translated from the bench to the bedside. The natural growth and success of the CMSR, the new initiative to increase collaborations between the CMSR and the Wellstone Muscular Dystrophy Cooperative Research Centers (MDCRC), the recent revamping up of our skeletal histopathology facilities, and the acquisition of state-of-the-art, sophisticated technologies through recent ARRA awards now necessitate the proposed organizational restructuring of our resources into separate Histology, Biochemistry and Molecular Imaging (HBMI) Core and Biomechanics and Mulfimodal Tissue Imaging (BMTI) Cores. This restructuring is sought to ensure the continued provision of efficient, high quality, histomorphometric, histologic, biomechanics, and in vivo imaging services to the investigators in the CMSR, such that the individual labs do not have to continually reproduce technical advances and modifications. Furthermore, the BMTI Core is designed to provide greater access of our large instrument fee for service Cores to unfunded physician scientists (UPS) and Research Assistant Professors (RAP) in our Core Center for Musculoskeletal Biology and Medicine (CCMBM). The Aims of the BMTI Core are to provide high quality, consistent, efficient and cost-effective anatomic imaging and biomechanical testing in small animal models of musculoskeletal trauma and disease; to enhance and refine imaging modalities and novel image processing algorithms to derive translational correlates of functional healing; and to provide affordable access for RAP and UPS to Core resources, and utilize their unique research expertise to train other investigators, staff, and trainees in the CCMBM. The approach we have chosen is designed to improve service to our funded investigators at the highest levels of efficiency and quality, and facilitate the advancement of our RAP and UPS to independence, establishing them as future leaders that could potentially be recruited by the top academic programs in the country.

由于在肌肉骨骼研究中心（CMSR）的战略重组，为提高效率，加速研究的速度并促进我们的NIH资助计划的临床翻译，因此提出了生物力学和多模式组织成像（BMTI）核心。随着CMSR的研究已越来越转化的方向，包括许多动物模型 骨科损伤和修复（例如关节炎，骨折愈合和同种异体移植愈合），有一个令人信服的理由，用于将组织学，基于组织和细胞的研究与纵向动物成像和组织生物力学评估相结合，以追求最小侵入性的恢复和修复的效果。 CMSR的自然增长和成功， 新举措旨在增加CMSR与井石肌肉营养不良协作研究中心（MDCRC），最近对我们的骨骼组织病理学设施的改进以及最先进的，最先进的，近期的ARRA奖项的收购，现在必须通过我们的资源来融入我们的资源，将我们的资源组建为单独的组织，Bio Chems Insecruction，Bio Chands Incormation，Bio Chands Incormation，Bio Chands Incormation，Bio Chands Incormantial ivelagence bio Chormatory Resighters（MDCRC）进行了改进 和分子成像（HBMI）核心和生物力学以及含偶像组织成像（BMTI）核心。寻求这种重组，以确保持续提供高效，高质量，组织学，组织学，生物力学以及为CMSR研究人员提供的体内成像服务，因此单个实​​验室不必继续再现技术进步和修改。此外，BMTI核心旨在在我们的肌肉骨骼生物学和医学核心中心（CCMBM）的无资助的医师科学家（UPS）和研究助理教授（RAP）提供更多的服务核心费用。 BMTI核心的目的是提供高质量，一致，高效和成本效益的解剖成像和生物力学测试，并在肌肉骨骼的小动物模型中提供 创伤和疾病；增强和完善成像方式和新颖的图像处理算法，以得出功能愈合的翻译相关性；并为RAP和UPS提供负担得起的核心资源，并利用其独特的研究专业知识来培训CCMBM的其他调查人员，员工和学员。我们选择的方法旨在改善最高效率和质量水平的资金调查人员的服务，并促进我们的说唱和UPS的发展，并将其建立为未来的领导者，这些领导者可能会被美国顶级学术计划招募。