Core Center for BioBehavioral Sciences of Communication Disorders

沟通障碍生物行为科学核心中心

• 批准号: 8721909
• 负责人: MABEL L RICE
• 金额: $ 29.78万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8721909
• 关键词: Adult; Area; Award; Behavioral; Caregivers; Child; Child Language; Clinical Trials; Cognitive; Collaborations; Communication; Communication impairment; Data; Data Collection; Databases; Dementia; Demography; Development; Diagnosis; Digital Computers; Documentation; Educational workshop; Elderly; Electronics; Engineering; Environment; Equipment; Etiology; Faculty; Funding; Future; Gene Expression Regulation; Genetic Predisposition to Disease; Growth; Guidelines; Health; Hearing; Holly; Home environment; Household; Impairment; Individual; Infant; Institutional Review Boards; Intervention; Investigation; Journals; Language; Language Development; Learning; Longevity; Mails; Measurement; Measures; Methods; Molecular; Natural regeneration; Nature; Newsletter; Outcome; Participant; Patients; Peer Review; Policies; Population; Production; Productivity; Publications; Recruitment Activity; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Science; Services; Site; Speech; Symptoms; System; Technical Expertise; Technology; Time; Tinnitus; Training; Translating; United States National Institutes of Health; Vestibular Hair Cells; Viral Vector; Visual; Work; age related; axon growth; biobehavior; data management; design; digital; equilibration disorder; hearing impairment; human subject; human subject protection; indexing; infancy; innovation; innovative technologies; intervention effect; lexical; meetings; population based; response; technology/technique; theories

DESCRIPTION (provided by applicant): In this renewal proposal, the Core Center for Biobehavioral Sciences of Communication Disorders is comprised of 12 affiliated investigators with a total of 16 NIH R01 awards. The topics focus on speech and language impairments, with a new investigator of hearing/balance impairments. An overarching theme is change overtime, which bridges behavioral and molecular levels of investigation. The individual research projects involve studies of symptoms, genetic etiology, diagnosis of and intervention with language impairments in children, language growth trajectories, sensorimotor aspects of speech production in infants, children and adults, speech and lexical representations in children and adults, age-related communicative decline in elder adults, clinical trials of intervention to chang the communication style of care-givers of patients with dementia, infant visual neuroperceptual development as a predictor of later cognitive and language development, clinical trials with a viral vector to induce regeneration of vestibular hair cells for the treatment of tinnitus/balance disorders, and gene regulation of axon growth related to cortical development. The specific aims are: 1) Increase the productivity and impact of research in R01 projects of the core users; 2) Form a collaborative environment to increase scientific interactions; 3) Make facilities available for research services; and 4) Provide relevant technical expertise to groups o investigators with common needs. A small Administrative Core manages the Center. Research support is provided by three cores: Participant Services (PARC), Digital and Electronic Engineering (DEEC) and Analytic Techniques and Technology (ATT). Core 1 Participant Recruitment and Management Core (PARC) Director: Holly Storkel DESCRIPTION (provided by applicant): The Participant Recruitment and Management Core, consisting of a full-time Coordinator and the Core Director, was designed from the ground up to provide services to assist Center investigators in the following ways: (1) The identification and recruitment of participants, (2) Management of contacts with participants in existing studies, and (3) Provide training in human subjects and act as a liaison between investigators, the local institutional review board (IRB) and human subject consortiums. PARC has established the necessary infrastructure to meet these aims. Specifically, PARC has designed a number of databases geared towards targeting households for recruitment and keeping track of individuals' participation in Center projects, as well as a database of regional organizations that can assist in participant recruitment either as recruitment sites or as resources for targeting likely participants. PARC also assists Center investigators' recruitment efforts by providing demography services to target specific geographical areas that would result in more efficient recruiting. Furthermore, PARC maintains regular contact with past participants through regular newsletter and birthday card mailings, and is able to employ a number of tracking methods to find "lost" households, thus maximizing participant retention. Finally, PARC brings together Center investigators and staff for workshops on current participant targeting and recruitment strategies and the latest developments in human subject policies. These specialized services are often not fundable through R01 mechanisms and are not provided elsewhere. For the future, PARC will expand the services provided under each aim during the next funding cycle to explore, implement, and provide guidelines to investigators on use of electronic outlets for recruitment and retention of participants as well as primary data collection and the human subjects protection issues associated with each of those uses. In addition, recruitment efforts during the next funding cycle will provide an increased focus on recruitment of populations with communication disorders, especially adult populations, to facilitate the pursuit of new research efforts by existing faculty. PARC works collaboratively with the DEEC and ATT cores in developing the data management systems for integrative science.

描述（由申请人提供）：在本次更新提案中，沟通障碍生物行为科学核心中心由 12 名附属研究人员组成，共有 16 名 NIH R01 奖项。这些主题集中在言语和语言障碍上，并有一位新的听力/平衡障碍调查员。一个首要主题是随着时间的推移而变化，它将行为和分子水平的研究联系起来。个别研究项目涉及症状、遗传病因学、儿童语言障碍的诊断和干预、语言成长轨迹、婴儿、儿童和成人言语产生的感觉运动方面、儿童和成人的言语和词汇表征、年龄相关的研究老年人的沟通能力下降、改变痴呆症患者护理人员沟通方式的干预临床试验、婴儿视觉神经知觉发育作为后期认知和语言发展的预测因子、使用病毒载体进行临床试验诱导前庭毛细胞再生以治疗耳鸣/平衡障碍，以及与皮质发育相关的轴突生长的基因调节。 具体目标是： 1）提高核心用户R01项目研究的生产力和影响力； 2）形成协作环境以增加科学互动； 3) 为研究服务提供设施； 4) 向有共同需求的研究者群体提供相关的技术专业知识。该中心由一个小型行政核心管理。研究支持由三个核心提供：参与者服务 (PARC)、数字和电子工程 (DEEC) 以及分析技术和技术 (ATT)。 核心1 参与者招募和管理核心 (PARC) 导演： 霍莉·斯托克尔 描述（由申请人提供）： 参与者招募和管理核心由一名全职协调员和核心主任组成，其设计目的是通过以下方式为中心调查人员提供服务： (1) 参与者招募和管理核心招募参与者，(2) 管理与现有研究参与者的联系，以及 (3) 提供人类受试者培训并充当研究人员、当地机构审查委员会 (IRB) 和人类受试者联盟之间的联络人。 PARC 已经建立了必要的基础设施来实现这些目标。具体而言，帕洛阿尔托研究中心设计了许多数据库，旨在以家庭为目标进行招募并跟踪个人对中心项目的参与情况，以及一个区域组织数据库，可以作为招募网站或作为目标可能的资源来协助招募参与者。参与者。 PARC 还通过针对特定地理区域提供人口统计服务来协助中心调查员的招募工作，从而提高招募效率。此外，帕洛阿尔托研究中心通过定期通讯和生日贺卡邮件与过去的参与者保持定期联系，并能够采用多种跟踪方法来寻找“丢失”的家庭，从而最大限度地保留参与者。最后，帕洛阿尔托研究中心将中心研究人员和工作人员聚集在一起，举办研讨会，讨论当前的参与者目标和招募策略以及人类受试者政策的最新发展。这些专门服务通常无法通过 R01 机制获得资助，并且不在其他地方提供。未来，帕洛阿尔托研究中心将在下一个资助周期扩大每个目标下提供的服务，以探索、实施并向研究人员提供有关使用电子渠道招募和保留参与者以及主要数据收集和人类受试者保护的指南与每种用途相关的问题。此外，下一个资助周期的招聘工作将更加注重招聘有沟通障碍的人群，特别是成年人口，以促进现有教师开展新的研究工作。 PARC 与 DEEC 和 ATT 核心合作开发综合科学的数据管理系统。